STRINGSTRING
NODAL NODAL PRDM14 PRDM14 STAT5B STAT5B CSMD2 CSMD2 VMP1 VMP1 M3W2K3_FELCA M3W2K3_FELCA HPGD HPGD CORIN CORIN EPO EPO TPPP3 TPPP3 DDR1 DDR1 GHRL GHRL GHSR GHSR RECK RECK CYP27C1 CYP27C1 TLE6 TLE6 ENDOU ENDOU BMPR2 BMPR2 CYP27B1 CYP27B1 PRL PRL JUNB JUNB SP3 SP3 MAGED2 MAGED2 LDOC1 LDOC1 DEDD DEDD H3F3A H3F3A ESR1 ESR1 VDR VDR PTN PTN STS STS EPN1 EPN1 CITED2 CITED2 CRHBP CRHBP PPARD PPARD CSMD1 CSMD1 HAVCR2 HAVCR2 MST1 MST1 IGFBP2 IGFBP2 DAZAP1 DAZAP1 ACSL4 ACSL4 ITGB4 ITGB4 HSD11B2 HSD11B2 LIF LIF ASH1L ASH1L PRDM1 PRDM1 FUT7 FUT7 A1CF A1CF HMX3 HMX3 ENSFCAP00000042577 ENSFCAP00000042577 MED1 MED1 TEAD4 TEAD4 PCSK5 PCSK5 PGF PGF GALK1 GALK1 POLR1B POLR1B ENSFCAP00000049367 ENSFCAP00000049367 UCN UCN STOX2 STOX2 STAT5A STAT5A NPPA NPPA PRDX3 PRDX3 CBS CBS TRIM28 TRIM28 LOC101089568 LOC101089568
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NODALNodal growth differentiation factor. (348 aa)
PRDM14PR/SET domain 14. (572 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
CSMD2CUB and Sushi multiple domains 2. (3632 aa)
VMP1Vacuole membrane protein 1. (406 aa)
M3W2K3_FELCAPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (236 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
CORINCorin, serine peptidase. (1045 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (921 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
TLE6TLE family member 6, subcortical maternal complex member. (583 aa)
ENDOUEndonuclease, poly(U) specific. (412 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SP3Sp3 transcription factor. (713 aa)
MAGED2MAGE family member D2. (586 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
DEDDDeath effector domain containing. (318 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
VDRVitamin D receptor. (441 aa)
PTNPleiotrophin. (179 aa)
STSSteroid sulfatase. (584 aa)
EPN1Epsin 1. (566 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
PPARDPeroxisome proliferator activated receptor delta. (464 aa)
CSMD1CUB and Sushi multiple domains 1. (3501 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
IGFBP2Insulin like growth factor binding protein 2. (330 aa)
DAZAP1DAZ associated protein 1. (406 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
ITGB4Integrin beta. (1828 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (405 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
ASH1LASH1 like histone lysine methyltransferase. (2965 aa)
PRDM1PR/SET domain 1. (821 aa)
FUT7Fucosyltransferase 7. (340 aa)
A1CFAPOBEC1 complementation factor. (598 aa)
HMX3H6 family homeobox 3. (357 aa)
ENSFCAP00000042577DUF4939 domain-containing protein. (113 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
TEAD4TEA domain transcription factor 4. (694 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1857 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
GALK1Galactokinase 1. (619 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
ENSFCAP00000049367annotation not available (113 aa)
UCNUrocortin. (126 aa)
STOX2Storkhead box 2. (926 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
PRDX3Peroxiredoxin 3. (270 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (633 aa)
TRIM28Tripartite motif containing 28. (821 aa)
LOC101089568Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (370 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (14%) [HD]