STRINGSTRING
HESX1 HESX1 DMC1 DMC1 ENSFCAP00000059307 ENSFCAP00000059307 BIK BIK SCAPER SCAPER FOXL2 FOXL2 AMH AMH TAF4 TAF4 STAT5A STAT5A LRRC6 LRRC6 LOC101087152 LOC101087152 NKX3-1 NKX3-1 ADGRG1 ADGRG1 SIX4 SIX4 PTX3 PTX3 HOXA9 HOXA9 SRD5A2 SRD5A2 RAB13 RAB13 BCL2L11 BCL2L11 CEBPB CEBPB NR5A1 NR5A1 GFRA1 GFRA1 IMMP2L IMMP2L TGFBR1 TGFBR1 GALK1 GALK1 NHLH1 NHLH1 SOX9 SOX9 FANCG FANCG DHH DHH WNT2B WNT2B INHBA INHBA EIF2B4 EIF2B4 FANCA FANCA BCL2L2 BCL2L2 ADAM29 ADAM29 ENSFCAP00000044777 ENSFCAP00000044777 ARID4A ARID4A GATA3 GATA3 IRX5 IRX5 WT1 WT1 HYAL3 HYAL3 ENSFCAP00000042864 ENSFCAP00000042864 PCYT1B PCYT1B WDR19 WDR19 RXFP2 RXFP2 LOC101094201 LOC101094201 ERCC1 ERCC1 ADAM20 ADAM20 SLIT2 SLIT2 NR5A2 NR5A2 SFRP2 SFRP2 BMPR1B BMPR1B SOX8 SOX8 PATZ1 PATZ1 LHX9 LHX9 HOXA11 HOXA11 SPATA2 SPATA2 SFRP1 SFRP1 VGF VGF FST FST NKX2-1 NKX2-1 FZD4 FZD4 SMAD4 SMAD4 GAS2 GAS2 SF1 SF1 CSMD1 CSMD1 SIRT1 SIRT1 ENSFCAP00000027236 ENSFCAP00000027236 ATM ATM KIF18A KIF18A EIF2B2 EIF2B2 GATA6 GATA6 UBE3A UBE3A TNFAIP6 TNFAIP6 ATN1 ATN1 ASPM ASPM GPR149 GPR149 FOXO3 FOXO3 CITED2 CITED2 FGF9 FGF9 NHLH2 NHLH2 BMP15 BMP15 WDR48 WDR48 AFP AFP TCF21 TCF21 TMF1 TMF1 ESR1 ESR1 H3F3A H3F3A OSR1 OSR1 BRCA2 BRCA2 ING2 ING2 EIF2S2 EIF2S2 REC8 REC8 RDH10 RDH10 LOC101084379 LOC101084379 RUSC1 RUSC1 ATRX ATRX LOC101088229 LOC101088229 NR0B1 NR0B1 SALL1 SALL1 YBX3 YBX3 MSH4 MSH4 GATA4 GATA4 DMRTA1 DMRTA1 MSH2 MSH2 ADAMTS1 ADAMTS1 TIPARP TIPARP NUP107 NUP107 NUPR1 NUPR1 SAFB2 SAFB2 SLIT3 SLIT3 GATA1 GATA1 KDR KDR LHCGR LHCGR PDGFRA PDGFRA NKX2-2 NKX2-2 LFNG LFNG HSD17B4 HSD17B4 NRIP1 NRIP1 EIF2B5 EIF2B5 AR AR DMRT1 DMRT1 LRP2 LRP2 CRKL CRKL TFAP2C TFAP2C PRDX4 PRDX4 TBC1D20 TBC1D20 KIT KIT MAS1 MAS1 CSMD2 CSMD2 STAT5B STAT5B KLHL10 KLHL10 CCDC182 CCDC182 NANOG NANOG COL9A3 COL9A3 SGPL1 SGPL1 FSHR FSHR SPO11 SPO11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HESX1HESX homeobox 1. (207 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (348 aa)
ENSFCAP00000059307Uncharacterized protein. (766 aa)
BIKUncharacterized protein. (245 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1401 aa)
FOXL2Forkhead box L2. (357 aa)
AMHAnti-Mullerian hormone. (800 aa)
TAF4TATA-box binding protein associated factor 4. (1099 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
LRRC6Leucine rich repeat containing 6. (476 aa)
LOC101087152Uncharacterized protein. (773 aa)
NKX3-1NK3 homeobox 1. (231 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (689 aa)
SIX4SIX homeobox 4. (784 aa)
PTX3Pentraxin 3. (381 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
RAB13Uncharacterized protein. (203 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
GFRA1GDNF family receptor alpha 1. (509 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
GALK1Galactokinase 1. (619 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
SOX9SRY-box transcription factor 9. (511 aa)
FANCGFA complementation group G. (626 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (545 aa)
FANCAFA complementation group A. (1476 aa)
BCL2L2BCL2 like 2. (193 aa)
ADAM29ADAM metallopeptidase domain 29. (960 aa)
ENSFCAP00000044777Uncharacterized protein. (321 aa)
ARID4AAT-rich interaction domain 4A. (1278 aa)
GATA3GATA binding protein 3. (444 aa)
IRX5Iroquois homeobox 5. (483 aa)
WT1WT1 transcription factor. (523 aa)
HYAL3Hyaluronidase. (419 aa)
ENSFCAP00000042864Uncharacterized protein. (787 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (427 aa)
WDR19WD repeat domain 19. (1342 aa)
RXFP2Relaxin family peptide receptor 2. (713 aa)
LOC101094201SCHIP-1 domain-containing protein. (489 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (329 aa)
ADAM20ADAM metallopeptidase domain 20. (729 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
SOX8SRY-box 8. (883 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
LHX9LIM homeobox 9. (487 aa)
HOXA11Homeobox A11. (327 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
VGFVGF nerve growth factor inducible. (616 aa)
FSTFollistatin. (423 aa)
NKX2-1NK2 homeobox 1. (399 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GAS2Growth arrest specific 2. (314 aa)
SF1Splicing factor 1. (670 aa)
CSMD1CUB and Sushi multiple domains 1. (3501 aa)
SIRT1Sirtuin 1. (745 aa)
ENSFCAP00000027236Uncharacterized protein. (708 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (896 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (403 aa)
GATA6GATA binding protein 6. (646 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (834 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
ATN1Atrophin 1. (1193 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
GPR149G protein-coupled receptor 149. (747 aa)
FOXO3Forkhead box O3. (672 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
WDR48WD repeat domain 48. (677 aa)
AFPAlpha fetoprotein. (609 aa)
TCF21Transcription factor 21. (179 aa)
TMF1TATA element modulatory factor 1. (1093 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
ING2Inhibitor of growth protein. (280 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit beta. (333 aa)
REC8REC8 meiotic recombination protein. (563 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
LOC101084379Homeobox domain-containing protein. (290 aa)
RUSC1RUN and SH3 domain containing 1. (907 aa)
ATRXATRX chromatin remodeler. (2486 aa)
LOC101088229Uncharacterized protein. (669 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
SALL1Spalt like transcription factor 1. (1238 aa)
YBX3Y-box binding protein 3. (361 aa)
MSH4DNA_MISMATCH_REPAIR_2 domain-containing protein. (935 aa)
GATA4GATA binding protein 4. (443 aa)
DMRTA1DMRT like family A1. (494 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (692 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
SAFB2Scaffold attachment factor B2. (1048 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
GATA1GATA binding protein 1. (413 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
NKX2-2NK2 homeobox 2. (273 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (556 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
ARAndrogen receptor. (903 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (378 aa)
LRP2LDL receptor related protein 2. (4646 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
TFAP2CTranscription factor AP-2 gamma. (546 aa)
PRDX4Peroxiredoxin 4. (306 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
CSMD2CUB and Sushi multiple domains 2. (3632 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
KLHL10Kelch like family member 10. (608 aa)
CCDC182Coiled-coil domain containing 182. (153 aa)
NANOGNanog homeobox. (311 aa)
COL9A3Collagen type IX alpha 3 chain. (681 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (671 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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