41 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
	STPG1	Sperm tail PG-rich repeat containing 1. (356 aa)
	AIFM2	Apoptosis inducing factor mitochondria associated 2. (491 aa)
	ENSFCAP00000054708	Uncharacterized protein. (102 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	NAIF1	Nuclear apoptosis inducing factor 1. (327 aa)
	THEM4	Thioesterase superfamily member 4. (238 aa)
	RHOT2	Ras homolog family member T2. (722 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (918 aa)
	HK2	Hexokinase 2. (917 aa)
	GGCT	Uncharacterized protein. (188 aa)
	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1. (691 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
	VDAC2	Voltage dependent anion channel 2. (294 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
	BNIP3L	BCL2 interacting protein 3 like. (219 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (204 aa)
	ENSFCAP00000025816	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
	BOK	BCL2 family apoptosis regulator BOK. (320 aa)
	IFI6	Interferon alpha inducible protein 6. (149 aa)
	BIK	Uncharacterized protein. (245 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (657 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (803 aa)
	BNIP3	BCL2 interacting protein 3. (187 aa)
	TIMM50	Translocase of inner mitochondrial membrane 50. (608 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (252 aa)
	NOL3	Nucleolar protein 3. (218 aa)
	BAK1	BCL2 antagonist/killer 1. (251 aa)
	ENSFCAP00000039745	Uncharacterized protein. (55 aa)
	ENSFCAP00000040280	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	BBC3	Uncharacterized protein. (193 aa)
	ATG3	Autophagy-related protein 3. (333 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM2	NDUFS1	ENSFCAP00000052069	ENSFCAP00000018728	Apoptosis inducing factor mitochondria associated 2.	NADH:ubiquinone oxidoreductase core subunit S1.	0.427
AIFM2	TP53	ENSFCAP00000052069	ENSFCAP00000045749	Apoptosis inducing factor mitochondria associated 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.502
BAD	BAK1	ENSFCAP00000047559	ENSFCAP00000059499	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.856
BAD	BAX	ENSFCAP00000047559	ENSFCAP00000000237	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.840
BAD	BCL2L11	ENSFCAP00000047559	ENSFCAP00000049779	BCL2 associated agonist of cell death.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.888
BAD	BID	ENSFCAP00000047559	ENSFCAP00000055705	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.798
BAD	BOK	ENSFCAP00000047559	ENSFCAP00000057223	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	SFN	ENSFCAP00000047559	ENSFCAP00000060640	BCL2 associated agonist of cell death.	Stratifin; Belongs to the 14-3-3 family.	0.645
BAK1	BAD	ENSFCAP00000059499	ENSFCAP00000047559	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.856
BAK1	BAX	ENSFCAP00000059499	ENSFCAP00000000237	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.866
BAK1	BBC3	ENSFCAP00000059499	ENSFCAP00000046125	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.820
BAK1	BCL2L11	ENSFCAP00000059499	ENSFCAP00000049779	BCL2 antagonist/killer 1.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.951
BAK1	BID	ENSFCAP00000059499	ENSFCAP00000055705	BCL2 antagonist/killer 1.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.994
BAK1	ERBB4	ENSFCAP00000059499	ENSFCAP00000042375	BCL2 antagonist/killer 1.	Receptor protein-tyrosine kinase.	0.493
BAK1	PMAIP1	ENSFCAP00000059499	ENSFCAP00000049753	BCL2 antagonist/killer 1.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.790
BAK1	PPIF	ENSFCAP00000059499	ENSFCAP00000025399	BCL2 antagonist/killer 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.413
BAK1	TP53	ENSFCAP00000059499	ENSFCAP00000045749	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.739
BAK1	VDAC2	ENSFCAP00000059499	ENSFCAP00000020840	BCL2 antagonist/killer 1.	Voltage dependent anion channel 2.	0.515
BAX	BAD	ENSFCAP00000000237	ENSFCAP00000047559	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death.	0.840
BAX	BAK1	ENSFCAP00000000237	ENSFCAP00000059499	BCL2 associated X, apoptosis regulator.	BCL2 antagonist/killer 1.	0.866