108 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNF34	Ring finger protein 34. (382 aa)
	HMOX1	Heme oxygenase 1. (404 aa)
	TRPM8	Transient receptor potential cation channel subfamily M member 8. (1104 aa)
	SLC25A27	Solute carrier family 25 member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. (362 aa)
	ENSFCAP00000061275	Uncharacterized protein. (97 aa)
	IER5L	Immediate early response 5 like. (409 aa)
	MKI67	FHA domain-containing protein. (2865 aa)
	ENSFCAP00000057069	Uncharacterized protein. (103 aa)
	NF1	Neurofibromin 1. (2856 aa)
	HIKESHI	Heat shock protein nuclear import factor hikeshi. (204 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
	SLC27A1	Solute carrier family 27 member 1. (796 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
	OPN4	Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). (487 aa)
	IER5	Immediate early response 5. (319 aa)
	DAXX-2	Daxx domain-containing protein. (769 aa)
	SLC12A5	Solute carrier family 12 member 5. (1196 aa)
	ENSFCAP00000049956	Uncharacterized protein. (78 aa)
	RBM3	RRM domain-containing protein. (227 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (655 aa)
	DHX36	DEAH-box helicase 36. (1012 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (522 aa)
	CIRBP	Cold inducible RNA binding protein. (172 aa)
	HSPB2	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
	DRGX	Uncharacterized protein. (264 aa)
	NGFR	Nerve growth factor receptor. (421 aa)
	PRDM12	PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (363 aa)
	ANO1	Anoctamin. (1029 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2498 aa)
	ADRB1	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (753 aa)
	PDCD6	Programmed cell death 6. (189 aa)
	GRIK2	Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
	ENSFCAP00000040280	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
	CDH8	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (833 aa)
	ENSFCAP00000039840	Uncharacterized protein. (76 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (478 aa)
	ENSFCAP00000039745	Uncharacterized protein. (55 aa)
	TRPV3	Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (791 aa)
	TRPM3	Transient receptor potential cation channel subfamily M member 3. (1711 aa)
	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	VGF	VGF nerve growth factor inducible. (616 aa)
	ENSFCAP00000034476	J domain-containing protein. (143 aa)
	ENSFCAP00000033453	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
	HSF1	Heat shock transcription factor 1. (527 aa)
	PIRT	Phosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
	ENSFCAP00000028894	RRM domain-containing protein. (97 aa)
	ENSFCAP00000028340	Uncharacterized protein. (110 aa)
	ENSFCAP00000025816	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
	DNAJA4	DnaJ heat shock protein family (Hsp40) member A4. (489 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (445 aa)
	M3XE40_FELCA	RRM domain-containing protein. (141 aa)
	HSBP1L1	Heat shock factor binding protein 1 like 1. (85 aa)
	ZNF516	Zinc finger protein 516. (1168 aa)
	TMEM135	Transmembrane protein 135. (458 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (643 aa)
	NOS1	Nitric oxide synthase 1. (1462 aa)
	PSIP1	PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). (530 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (469 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1653 aa)
	SAXO2	Stabilizer of axonemal microtubules 2. (399 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
	BAG3	BCL2 associated athanogene 3. (565 aa)
	TFEC	Transcription factor EC. (436 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	SCARA5	Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (510 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
	MMP24	Matrix metallopeptidase 24. (630 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (503 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (552 aa)
	ARPP21	cAMP regulated phosphoprotein 21. (811 aa)
	LXN	Latexin. (222 aa)
	TCIM	Transcriptional and immune response regulator. (107 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
	PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
	SLU7	SLU7 homolog, splicing factor. (586 aa)
	SLC52A3	Solute carrier family 52 member 3. (469 aa)
	ADRB3	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity). (398 aa)
	PLAC8B	Placenta associated 8 B. (113 aa)
	SLC29A1	Heat shock protein 90 alpha family class B member 1. (740 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1500 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	TRPV2	Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (841 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
	HTR1B	5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	HSPB6	Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (161 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (706 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (475 aa)
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
	SAXO1	Stabilizer of axonemal microtubules 1. (477 aa)
	DAXX	Death domain associated protein. (748 aa)
	CKM	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (424 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (761 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (414 aa)
	CRYAA	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (173 aa)
	RHO	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADM	ACADVL	ENSFCAP00000025061	ENSFCAP00000047823	Acyl-CoA dehydrogenase medium chain.	Acyl-CoA dehydrogenase very long chain.	0.952
ACADM	SLC27A1	ENSFCAP00000025061	ENSFCAP00000052419	Acyl-CoA dehydrogenase medium chain.	Solute carrier family 27 member 1.	0.477
ACADVL	ACADM	ENSFCAP00000047823	ENSFCAP00000025061	Acyl-CoA dehydrogenase very long chain.	Acyl-CoA dehydrogenase medium chain.	0.952
ACADVL	SLC27A1	ENSFCAP00000047823	ENSFCAP00000052419	Acyl-CoA dehydrogenase very long chain.	Solute carrier family 27 member 1.	0.488
ADRB1	ADRB2	ENSFCAP00000042036	ENSFCAP00000007370	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.901
ADRB1	ADRB3	ENSFCAP00000042036	ENSFCAP00000009674	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	0.959
ADRB1	PRKACA	ENSFCAP00000042036	ENSFCAP00000018754	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.462
ADRB2	ADRB1	ENSFCAP00000007370	ENSFCAP00000042036	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.901
ADRB2	ADRB3	ENSFCAP00000007370	ENSFCAP00000009674	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	0.959
ADRB2	PRKACA	ENSFCAP00000007370	ENSFCAP00000018754	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.480
ADRB3	ADRB1	ENSFCAP00000009674	ENSFCAP00000042036	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.959
ADRB3	ADRB2	ENSFCAP00000009674	ENSFCAP00000007370	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.959
ADRB3	PLIN1	ENSFCAP00000009674	ENSFCAP00000045890	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Perilipin; Belongs to the perilipin family.	0.588
ADRB3	PRKACA	ENSFCAP00000009674	ENSFCAP00000018754	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.512
ADRB3	UCP1	ENSFCAP00000009674	ENSFCAP00000008252	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.642
ANO1	TRPA1	ENSFCAP00000042204	ENSFCAP00000038035	Anoctamin.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.588
ANO1	TRPM3	ENSFCAP00000042204	ENSFCAP00000038187	Anoctamin.	Transient receptor potential cation channel subfamily M member 3.	0.473
ANO1	TRPV1	ENSFCAP00000042204	ENSFCAP00000007337	Anoctamin.	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.461
ANO1	TRPV4	ENSFCAP00000042204	ENSFCAP00000053057	Anoctamin.	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family.	0.419
ASIC3	TRPA1	ENSFCAP00000015581	ENSFCAP00000038035	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.807