STRINGSTRING
RNF34 RNF34 HMOX1 HMOX1 TRPM8 TRPM8 SLC25A27 SLC25A27 ENSFCAP00000061275 ENSFCAP00000061275 IER5L IER5L MKI67 MKI67 ENSFCAP00000057069 ENSFCAP00000057069 NF1 NF1 HIKESHI HIKESHI TRPV4 TRPV4 SLC27A1 SLC27A1 FGF1 FGF1 OPN4 OPN4 IER5 IER5 DAXX-2 DAXX-2 SLC12A5 SLC12A5 ENSFCAP00000049956 ENSFCAP00000049956 RBM3 RBM3 YWHAE YWHAE ACADVL ACADVL DHX36 DHX36 PLIN1 PLIN1 CIRBP CIRBP HSPB2 HSPB2 DRGX DRGX NGFR NGFR PRDM12 PRDM12 ANO1 ANO1 TPR TPR ADRB1 ADRB1 HSP90AA1 HSP90AA1 PDCD6 PDCD6 GRIK2 GRIK2 ENSFCAP00000040280 ENSFCAP00000040280 CDH8 CDH8 ENSFCAP00000039840 ENSFCAP00000039840 DNAJA3 DNAJA3 ENSFCAP00000039745 ENSFCAP00000039745 TRPV3 TRPV3 TRPM3 TRPM3 ST8SIA1 ST8SIA1 TRPA1 TRPA1 VGF VGF ENSFCAP00000034476 ENSFCAP00000034476 ENSFCAP00000033453 ENSFCAP00000033453 HSF1 HSF1 PIRT PIRT CASQ1 CASQ1 ENSFCAP00000028894 ENSFCAP00000028894 ENSFCAP00000028340 ENSFCAP00000028340 ENSFCAP00000025816 ENSFCAP00000025816 DNAJA4 DNAJA4 ACADM ACADM M3XE40_FELCA M3XE40_FELCA HSBP1L1 HSBP1L1 ZNF516 ZNF516 TMEM135 TMEM135 GCLC GCLC NOS1 NOS1 PSIP1 PSIP1 RBBP7 RBBP7 EIF2AK4 EIF2AK4 SAXO2 SAXO2 HSPD1 HSPD1 BAG3 BAG3 TFEC TFEC HSPB1 HSPB1 PRKACA PRKACA SCARA5 SCARA5 DNAJC3 DNAJC3 MMP24 MMP24 HTR2B HTR2B TP53INP1 TP53INP1 ASIC3 ASIC3 ARPP21 ARPP21 LXN LXN TCIM TCIM EIF2AK3 EIF2AK3 PCSK1N PCSK1N SLU7 SLU7 SLC52A3 SLC52A3 ADRB3 ADRB3 PLAC8B PLAC8B SLC29A1 SLC29A1 TRPM2 TRPM2 UCP1 UCP1 TRPV2 TRPV2 IL1A IL1A ADRB2 ADRB2 TRPV1 TRPV1 HSPA2 HSPA2 EIF2B5 EIF2B5 HTR1B HTR1B HTRA2 HTRA2 HSPB6 HSPB6 CLPB CLPB P2RX3 P2RX3 UCP2 UCP2 SAXO1 SAXO1 DAXX DAXX CKM CKM APPL2 APPL2 VCP VCP NR2F6 NR2F6 CRYAA CRYAA RHO RHO MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF34Ring finger protein 34. (382 aa)
HMOX1Heme oxygenase 1. (404 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
SLC25A27Solute carrier family 25 member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. (362 aa)
ENSFCAP00000061275Uncharacterized protein. (97 aa)
IER5LImmediate early response 5 like. (409 aa)
MKI67FHA domain-containing protein. (2865 aa)
ENSFCAP00000057069Uncharacterized protein. (103 aa)
NF1Neurofibromin 1. (2856 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (204 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
SLC27A1Solute carrier family 27 member 1. (796 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
OPN4Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). (487 aa)
IER5Immediate early response 5. (319 aa)
DAXX-2Daxx domain-containing protein. (769 aa)
SLC12A5Solute carrier family 12 member 5. (1196 aa)
ENSFCAP00000049956Uncharacterized protein. (78 aa)
RBM3RRM domain-containing protein. (227 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
DHX36DEAH-box helicase 36. (1012 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
CIRBPCold inducible RNA binding protein. (172 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
DRGXUncharacterized protein. (264 aa)
NGFRNerve growth factor receptor. (421 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (363 aa)
ANO1Anoctamin. (1029 aa)
TPRTranslocated promoter region, nuclear basket protein. (2498 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (753 aa)
PDCD6Programmed cell death 6. (189 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
ENSFCAP00000040280Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (833 aa)
ENSFCAP00000039840Uncharacterized protein. (76 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (478 aa)
ENSFCAP00000039745Uncharacterized protein. (55 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (791 aa)
TRPM3Transient receptor potential cation channel subfamily M member 3. (1711 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
VGFVGF nerve growth factor inducible. (616 aa)
ENSFCAP00000034476J domain-containing protein. (143 aa)
ENSFCAP0000003345314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
HSF1Heat shock transcription factor 1. (527 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
ENSFCAP00000028894RRM domain-containing protein. (97 aa)
ENSFCAP00000028340Uncharacterized protein. (110 aa)
ENSFCAP00000025816Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (489 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (445 aa)
M3XE40_FELCARRM domain-containing protein. (141 aa)
HSBP1L1Heat shock factor binding protein 1 like 1. (85 aa)
ZNF516Zinc finger protein 516. (1168 aa)
TMEM135Transmembrane protein 135. (458 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (643 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
PSIP1PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). (530 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1653 aa)
SAXO2Stabilizer of axonemal microtubules 2. (399 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
TFECTranscription factor EC. (436 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (510 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
MMP24Matrix metallopeptidase 24. (630 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (552 aa)
ARPP21cAMP regulated phosphoprotein 21. (811 aa)
LXNLatexin. (222 aa)
TCIMTranscriptional and immune response regulator. (107 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
SLU7SLU7 homolog, splicing factor. (586 aa)
SLC52A3Solute carrier family 52 member 3. (469 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity). (398 aa)
PLAC8BPlacenta associated 8 B. (113 aa)
SLC29A1Heat shock protein 90 alpha family class B member 1. (740 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1500 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (841 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (161 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (706 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (475 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
SAXO1Stabilizer of axonemal microtubules 1. (477 aa)
DAXXDeath domain associated protein. (748 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (424 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (761 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (414 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (173 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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