34 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VGF	VGF nerve growth factor inducible. (616 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	RNF34	Ring finger protein 34. (382 aa)
	ENSFCAP00000039745	Uncharacterized protein. (55 aa)
	CDH8	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (833 aa)
	ENSFCAP00000040280	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
	ADRB1	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
	CIRBP	Cold inducible RNA binding protein. (172 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (522 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (655 aa)
	RBM3	RRM domain-containing protein. (227 aa)
	SLC27A1	Solute carrier family 27 member 1. (796 aa)
	SLC25A27	Solute carrier family 25 member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. (362 aa)
	ENSFCAP00000028894	RRM domain-containing protein. (97 aa)
	ENSFCAP00000025816	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (445 aa)
	M3XE40_FELCA	RRM domain-containing protein. (141 aa)
	ZNF516	Zinc finger protein 516. (1168 aa)
	TMEM135	Transmembrane protein 135. (458 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1653 aa)
	SAXO2	Stabilizer of axonemal microtubules 2. (399 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
	PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
	ADRB3	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity). (398 aa)
	PLAC8B	Placenta associated 8 B. (113 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (475 aa)
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
	SAXO1	Stabilizer of axonemal microtubules 1. (477 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADM	ACADVL	ENSFCAP00000025061	ENSFCAP00000047823	Acyl-CoA dehydrogenase medium chain.	Acyl-CoA dehydrogenase very long chain.	0.952
ACADM	SLC27A1	ENSFCAP00000025061	ENSFCAP00000052419	Acyl-CoA dehydrogenase medium chain.	Solute carrier family 27 member 1.	0.477
ACADVL	ACADM	ENSFCAP00000047823	ENSFCAP00000025061	Acyl-CoA dehydrogenase very long chain.	Acyl-CoA dehydrogenase medium chain.	0.952
ACADVL	SLC27A1	ENSFCAP00000047823	ENSFCAP00000052419	Acyl-CoA dehydrogenase very long chain.	Solute carrier family 27 member 1.	0.488
ADRB1	ADRB2	ENSFCAP00000042036	ENSFCAP00000007370	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.901
ADRB1	ADRB3	ENSFCAP00000042036	ENSFCAP00000009674	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	0.959
ADRB2	ADRB1	ENSFCAP00000007370	ENSFCAP00000042036	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.901
ADRB2	ADRB3	ENSFCAP00000007370	ENSFCAP00000009674	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	0.959
ADRB3	ADRB1	ENSFCAP00000009674	ENSFCAP00000042036	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.959
ADRB3	ADRB2	ENSFCAP00000009674	ENSFCAP00000007370	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.959
ADRB3	PLIN1	ENSFCAP00000009674	ENSFCAP00000045890	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Perilipin; Belongs to the perilipin family.	0.588
ADRB3	UCP1	ENSFCAP00000009674	ENSFCAP00000008252	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity).	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.642
DNAJC3	HSPA2	ENSFCAP00000017307	ENSFCAP00000007243	DnaJ heat shock protein family (Hsp40) member C3.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.440
EIF2AK3	EIF2AK4	ENSFCAP00000011789	ENSFCAP00000020329	Eukaryotic translation initiation factor 2 alpha kinase 3.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.478
EIF2AK4	EIF2AK3	ENSFCAP00000020329	ENSFCAP00000011789	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.478
ENSFCAP00000025816	HSPA2	ENSFCAP00000025816	ENSFCAP00000007243	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.423
ENSFCAP00000039745	HSPA2	ENSFCAP00000039745	ENSFCAP00000007243	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.423
ENSFCAP00000040280	HSPA2	ENSFCAP00000040280	ENSFCAP00000007243	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.423
HSPA2	DNAJC3	ENSFCAP00000007243	ENSFCAP00000017307	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	DnaJ heat shock protein family (Hsp40) member C3.	0.440
HSPA2	ENSFCAP00000025816	ENSFCAP00000007243	ENSFCAP00000025816	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.423