STRINGSTRING
RDH11 RDH11 RBM4 RBM4 POLK POLK SIRT1 SIRT1 CUL4B CUL4B IL12B IL12B ZRANB3 ZRANB3 C9orf116 C9orf116 IMPACT IMPACT ERCC6 ERCC6 CRY1 CRY1 DDB1 DDB1 GNAQ GNAQ PRKAA1 PRKAA1 MC1R MC1R FOXB1 FOXB1 N4BP1 N4BP1 RHNO1 RHNO1 USP1 USP1 RCVRN RCVRN BCL3 BCL3 PDE6C PDE6C PRIMPOL PRIMPOL M3X4J6_FELCA M3X4J6_FELCA CDK5 CDK5 SMPD1 SMPD1 TREX1 TREX1 PPID PPID DDHD2 DDHD2 TYR TYR CDKN1A CDKN1A REEP6 REEP6 CDKN2D CDKN2D FBXL3 FBXL3 BRCA2 BRCA2 EIF2S1 EIF2S1 ZBTB1 ZBTB1 AIPL1 AIPL1 GNGT1 GNGT1 CASP9 CASP9 TRIM32 TRIM32 WRN WRN PPP1CA PPP1CA USP47 USP47 DDB2 DDB2 UBE2A UBE2A TP53INP1 TP53INP1 KRAS KRAS ATR ATR MMP3 MMP3 ACTR5 ACTR5 RGS9 RGS9 PER1 PER1 DCUN1D3 DCUN1D3 CHEK1 CHEK1 NETO1 NETO1 INO80 INO80 PBK PBK GRIN2A GRIN2A METTL3 METTL3 KDM1A KDM1A STK11 STK11 GUCA1A GUCA1A MSH2 MSH2 BRAF BRAF OPN1LW OPN1LW IL12A IL12A TANC1 TANC1 PIK3R1 PIK3R1 MMP12 MMP12 TMEM161A TMEM161A POLH POLH GRM6 GRM6 FBXL8 FBXL8 PCNA PCNA GJA10 GJA10 ROM1 ROM1 CDC25A CDC25A IFT20 IFT20 NEDD4 NEDD4 PDE6B PDE6B TIMP1 TIMP1 POLD3 POLD3 CTNS CTNS SLC24A4 SLC24A4 MSH6 MSH6 HYAL2 HYAL2 GNAT1 GNAT1 NPTN NPTN CREBBP CREBBP PARP1 PARP1 CCAR2 CCAR2 RDH13 RDH13 SLC1A3 SLC1A3 EP300 EP300 AKT1 AKT1 SLC4A10 SLC4A10 PER3 PER3 LOC101085685 LOC101085685 PRPH2 PRPH2 ERCC4 ERCC4 PRKCD PRKCD CACNA1F CACNA1F SLC7A11 SLC7A11 AKT3 AKT3 HIF1A HIF1A CABP4 CABP4 NOC2L NOC2L RUVBL2 RUVBL2 CRY2 CRY2 PML PML UVSSA UVSSA TP53I13 TP53I13 CNGB1 CNGB1 ERCC2 ERCC2 ZZEF1 ZZEF1 XPC XPC RGR RGR APP APP NR2F6 NR2F6 OPN1SW OPN1SW CRB1 CRB1 MAP3K4 MAP3K4 CHRM1 CHRM1 POLD1 POLD1 SIK1 SIK1 RHO RHO CPT1B CPT1B DCT DCT AQP1 AQP1 CACNA2D4 CACNA2D4 ITGB1 ITGB1 CASP3 CASP3 RS1 RS1 OPN3 OPN3 CACNB4 CACNB4 BHLHE40 BHLHE40 RO60 RO60 TIPIN TIPIN LOC101085685-2 LOC101085685-2 RBM4B RBM4B HMGCR HMGCR COPS9 COPS9 TTC36 TTC36 TRPM1 TRPM1 LRRN4 LRRN4 TAFA2 TAFA2 PDE1B PDE1B MAP4K3 MAP4K3 ATOH7 ATOH7 NDRG4 NDRG4 ERCC1 ERCC1 EGFR EGFR GNA11 GNA11 FBXL12 FBXL12 HYAL3 HYAL3 PER2 PER2 OPN5 OPN5 C10orf90 C10orf90 DTL DTL USP2 USP2 EXT1 EXT1 MYC MYC TP53 TP53 NOG NOG B4GALT2 B4GALT2 DHX36 DHX36 GPR88 GPR88 MFAP4 MFAP4 RELA RELA FBXL22 FBXL22 SEMA5B SEMA5B FBXL17 FBXL17 TULP1 TULP1 MECP2 MECP2 SYNGAP1 SYNGAP1 RGS9BP RGS9BP NFATC4 NFATC4 SIRT6 SIRT6 CCND1 CCND1 OPN4 OPN4 BMF BMF AURKB AURKB SLC1A2 SLC1A2 UBE4B UBE4B SPRTN SPRTN FBXL21P FBXL21P SDE2 SDE2 RIC8A RIC8A ERCC8 ERCC8 ENSFCAP00000055026 ENSFCAP00000055026 XPA XPA NPS NPS RHBDD1 RHBDD1 NF1 NF1 GNAT2 GNAT2 USF1 USF1 ELANE ELANE REV1 REV1 PPP1R1B PPP1R1B ERCC3 ERCC3 CAT CAT CASP7 CASP7 UBE2B UBE2B BEST1 BEST1 PTPRK PTPRK BAK1 BAK1 GNB5 GNB5 AKT2 AKT2 ENSFCAP00000059689 ENSFCAP00000059689 CRTC1 CRTC1 BEST3 BEST3 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RDH11Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (426 aa)
RBM4RNA binding motif protein 4. (365 aa)
POLKDNA polymerase kappa. (863 aa)
SIRT1Sirtuin 1. (745 aa)
CUL4BCullin 4B; Belongs to the cullin family. (911 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1072 aa)
C9orf116Chromosome 9 open reading frame 116. (146 aa)
IMPACTImpact RWD domain protein. (331 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
GNAQG protein subunit alpha q. (359 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis (By similarity). (317 aa)
FOXB1Forkhead box B1. (325 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (784 aa)
RCVRNRecoverin. (338 aa)
BCL3BCL3 transcription coactivator. (454 aa)
PDE6CPhosphodiesterase. (846 aa)
PRIMPOLPrimase and DNA directed polymerase. (556 aa)
M3X4J6_FELCAUncharacterized protein. (61 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (619 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
DDHD2DDHD domain containing 2. (670 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. (529 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
REEP6Receptor expression-enhancing protein. (230 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
AIPL1Aryl hydrocarbon receptor interacting protein-like 1. (328 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
TRIM32Uncharacterized protein. (669 aa)
WRNWRN RecQ like helicase. (1406 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
KRASUncharacterized protein. (380 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
MMP3Matrix metallopeptidase 3. (478 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (615 aa)
RGS9Regulator of G protein signaling 9. (668 aa)
PER1Period circadian regulator 1. (1373 aa)
DCUN1D3Defective in cullin neddylation 1 domain containing 3. (304 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
NETO1Neuropilin and tolloid like 1. (533 aa)
INO80INO80 complex ATPase subunit. (1620 aa)
PBKPDZ binding kinase. (337 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (558 aa)
KDM1ALysine demethylase 1A. (944 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
GUCA1AGuanylate cyclase activator 1A. (275 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
OPN1LWLong-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (364 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1864 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
TMEM161ATransmembrane protein 161A. (511 aa)
POLHDNA polymerase eta. (712 aa)
GRM6Glutamate metabotropic receptor 6. (878 aa)
FBXL8F-box domain-containing protein. (374 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
GJA10Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (491 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
CDC25ACell division cycle 25A. (524 aa)
IFT20Intraflagellar transport 20. (158 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1323 aa)
PDE6BPhosphodiesterase. (880 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (305 aa)
POLD3DNA polymerase delta 3, accessory subunit. (464 aa)
CTNSCystinosin, lysosomal cystine transporter. (399 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1359 aa)
HYAL2Hyaluronidase. (780 aa)
GNAT1G protein subunit alpha transducin 1. (350 aa)
NPTNNeuroplastin. (446 aa)
CREBBPCREB binding protein. (2444 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
CCAR2Cell cycle and apoptosis regulator 2. (918 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
SLC1A3Amino acid transporter. (542 aa)
EP300E1A binding protein p300. (2425 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC4A10Anion exchange protein. (1118 aa)
PER3PAS domain-containing protein. (397 aa)
LOC101085685Uncharacterized protein. (503 aa)
PRPH2Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. (346 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
SLC7A11Solute carrier family 7 member 11. (503 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
CABP4Calcium binding protein 4. (274 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (749 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CRY2Cryptochrome circadian regulator 2. (594 aa)
PMLPromyelocytic leukemia. (876 aa)
UVSSAUV stimulated scaffold protein A. (663 aa)
TP53I13Tumor protein p53 inducible protein 13. (394 aa)
CNGB1Cyclic nucleotide-binding domain-containing protein. (1204 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (2956 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (944 aa)
RGRRetinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (414 aa)
OPN1SWOpsin 1, short wave sensitive. (349 aa)
CRB1Crumbs cell polarity complex component 1. (1405 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1599 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
POLD1DNA polymerase. (1107 aa)
SIK1Uncharacterized protein. (780 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
DCTDopachrome tautomerase. (664 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (310 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1123 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
RS1Retinoschisin 1. (224 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (519 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
RO60Ro60, Y RNA binding protein. (538 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
LOC101085685-2XPGI domain-containing protein. (418 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
COPS9Uncharacterized protein. (57 aa)
TTC36Tetratricopeptide repeat domain 36. (189 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1655 aa)
LRRN4Leucine rich repeat neuronal 4. (740 aa)
TAFA2TAFA chemokine like family member 2. (144 aa)
PDE1BPhosphodiesterase. (535 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (916 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
NDRG4NDRG family member 4. (424 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (329 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
GNA11G protein subunit alpha 11. (359 aa)
FBXL12F-box and leucine rich repeat protein 12. (348 aa)
HYAL3Hyaluronidase. (419 aa)
PER2Period circadian regulator 2. (1260 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (376 aa)
C10orf90Chromosome 10 open reading frame 90. (655 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (398 aa)
DHX36DEAH-box helicase 36. (1012 aa)
GPR88G protein-coupled receptor 88. (384 aa)
MFAP4Microfibril associated protein 4. (359 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
FBXL22Uncharacterized protein. (228 aa)
SEMA5BSemaphorin 5B. (1100 aa)
FBXL17F-box and leucine rich repeat protein 17. (699 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (545 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
RGS9BPRegulator of G protein signaling 9 binding protein. (235 aa)
NFATC4Nuclear factor of activated T cells 4. (930 aa)
SIRT6Sirtuin 6. (412 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
OPN4Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). (487 aa)
BMFBcl2 modifying factor. (287 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (408 aa)
SLC1A2Amino acid transporter. (579 aa)
UBE4BUbiquitination factor E4B. (1537 aa)
SPRTNSprT-like N-terminal domain. (488 aa)
FBXL21PF-box domain-containing protein. (482 aa)
SDE2SDE2 telomere maintenance homolog. (588 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (591 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (448 aa)
ENSFCAP00000055026XPGN domain-containing protein. (740 aa)
XPAXPA, DNA damage recognition and repair factor. (280 aa)
NPSNeuropeptide S. (114 aa)
RHBDD1Rhomboid domain containing 1. (320 aa)
NF1Neurofibromin 1. (2856 aa)
GNAT2G protein subunit alpha transducin 2. (374 aa)
USF1Upstream transcription factor 1. (444 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1273 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (822 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (616 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (409 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (274 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (654 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1485 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
GNB5G protein subunit beta 5. (403 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ENSFCAP00000059689Uncharacterized protein. (377 aa)
CRTC1CREB regulated transcription coactivator 1. (654 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (680 aa)
MAPK13Mitogen-activated protein kinase. (402 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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