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| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | CHMP4A | Charged multivesicular body protein 4A. (220 aa) |
| | TSC2 | TSC complex subunit 2. (1806 aa) |
| | ENSFCAP00000033718 | ZnF_CDGSH domain-containing protein. (99 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (421 aa) |
| | TRIM5 | Uncharacterized protein. (486 aa) |
| | RAB39B | RAB39B, member RAS oncogene family. (213 aa) |
| | USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (975 aa) |
| | LOC101092021 | Uncharacterized protein. (235 aa) |
| | CLN3 | Battenin. (438 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | DRAM2 | DNA damage regulated autophagy modulator 2. (275 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa) |
| | MTMR3 | Myotubularin related protein 3. (1222 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | LZTS1 | Leucine zipper tumor suppressor 1. (606 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | PAFAH1B2 | Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa) |
| | TRIM13 | Tripartite motif containing 13. (409 aa) |
| | SMCR8 | SMCR8-C9orf72 complex subunit. (938 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | WDR6 | WD repeat domain 6. (1117 aa) |
| | VPS13C | Vacuolar protein sorting 13 homolog C. (3752 aa) |
| | LOC101089184 | Uncharacterized protein. (775 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa) |
| | CCNY | Cyclin Y; Belongs to the cyclin family. (341 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa) |
| | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1. (401 aa) |
| | M3XAD3_FELCA | Uncharacterized protein. (225 aa) |
| | CISD2 | CDGSH iron sulfur domain 2. (135 aa) |
| | TRIM6 | Tripartite motif containing 6. (487 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | SNX18 | Sorting nexin. (624 aa) |
| | RRAGA | Ras related GTP binding A. (313 aa) |
| | LRSAM1 | Leucine rich repeat and sterile alpha motif containing 1. (728 aa) |
| | RRAGD | Ras related GTP binding D. (396 aa) |
| | RAB8B | RAB8B, member RAS oncogene family. (207 aa) |
| | PHF23 | PHD finger protein 23. (403 aa) |
| | NPRL3 | NPR3 like, GATOR1 complex subunit. (569 aa) |
| | MTM1 | Myotubularin 1. (603 aa) |
| | TRIM38 | Tripartite motif containing 38. (514 aa) |
| | DCN | Decorin; May affect the rate of fibrils formation. (360 aa) |
| | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa) |
| | USP33 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (912 aa) |
| | RALB | RAS like proto-oncogene B. (206 aa) |
| | BAG3 | BCL2 associated athanogene 3. (565 aa) |
| | M3WWT0_FELCA | Rhomboid domain-containing protein. (188 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (878 aa) |
| | TRIM32 | Uncharacterized protein. (669 aa) |
| | PLEKHF1 | Pleckstrin homology and FYVE domain containing 1. (280 aa) |
| | TRIML2 | Tripartite motif family like 2. (442 aa) |
| | ATG14 | Autophagy related 14. (510 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12. (453 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (503 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (646 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (239 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | DAPL1 | Death associated protein like 1. (107 aa) |
| | TRIM68 | Tripartite motif containing 68. (485 aa) |
| | KDM4A | Lysine demethylase 4A. (1067 aa) |
| | RRAGB | Ras related GTP binding B. (374 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | ATG13 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1301 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | BECN1 | Beclin 1. (448 aa) |
| | SOGA1 | Suppressor of glucose, autophagy associated 1. (1657 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (624 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | ATG2A | Autophagy related 2A. (1928 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | CLEC16A | C-type lectin domain containing 16A. (1045 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (623 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1113 aa) |
| | SUPT5H | Transcription elongation factor SPT5. (1087 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1593 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1161 aa) |
| | FBXO7 | F-box protein 7. (444 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa) |
| | RRAGC | Ras related GTP binding C. (398 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) |
| | TBC1D25 | TBC1 domain family member 25. (687 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | ADRB2 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa) |
| | UFL1 | UFM1 specific ligase 1. (792 aa) |
| | TRIML1 | Tripartite motif family like 1. (474 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | RASIP1 | Ras interacting protein 1. (943 aa) |
| | SNX30 | Sorting nexin family member 30. (449 aa) |
| | FBXL2 | F-box and leucine rich repeat protein 2. (413 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | ENDOG | Endonuclease. (298 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa) |
| | DAPK1 | Death associated protein kinase 1. (1429 aa) |
| | CTTN | Cortactin. (538 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (473 aa) |
| | HTT | Huntingtin. (3140 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | VPS13D | Vacuolar protein sorting 13 homolog D. (4389 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (825 aa) |
| | PARL | Rhomboid domain-containing protein. (379 aa) |
| | MTMR9 | Myotubularin related protein 9. (547 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa) |
| | FOXK2 | Forkhead box K2. (658 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | DDIT3 | DNA damage inducible transcript 3. (167 aa) |
| | NPRL2 | NPR2 like, GATOR1 complex subunit. (380 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | CD4H9orf72 | Chromosome D4 C9orf72 homolog. (481 aa) |
| | CTSA | Carboxypeptidase; Belongs to the peptidase S10 family. (497 aa) |
| | SNX4 | Sorting nexin 4. (459 aa) |
| | HMOX1 | Heme oxygenase 1. (404 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (462 aa) |
| | RUFY4 | RUN and FYVE domain containing 4. (697 aa) |
| | BNIP3 | BCL2 interacting protein 3. (187 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1407 aa) |
| | CALCOCO2 | Calcium binding and coiled-coil domain 2. (474 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (435 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (694 aa) |
| | GPR137B | G protein-coupled receptor 137B. (620 aa) |
| | TMEM39B | Transmembrane protein 39B. (512 aa) |
| | WIPI1 | WD repeat domain, phosphoinositide interacting 1. (470 aa) |
| | SVIP | Uncharacterized protein. (124 aa) |
| | RNF31 | Uncharacterized protein. (1081 aa) |
| | TMEM59 | Uncharacterized protein. (335 aa) |
| | SH3BP4 | SH3 domain binding protein 4. (1056 aa) |
| | HMGB1 | Uncharacterized protein. (233 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (320 aa) |
| | TMEM39A | Transmembrane protein 39A. (505 aa) |
| | ENSFCAP00000057195 | Uncharacterized protein. (34 aa) |
| | SNX7 | Sorting nexin 7. (513 aa) |
| | DAP | Uncharacterized protein. (165 aa) |
| | UVRAG | UV radiation resistance associated. (718 aa) |
| | TECPR1 | Tectonin beta-propeller repeat containing 1. (1201 aa) |
| | SIRT2 | Sirtuin 2. (497 aa) |
| | UBQLN4 | Ubiquilin 4. (608 aa) |
| | SESN2 | Sestrin 2. (516 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | RMC1 | Regulator of MON1-CCZ1. (657 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (749 aa) |
| | MID2 | Midline 2. (735 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | CDK16 | Cyclin dependent kinase 16. (570 aa) |
| | STING1 | Stimulator of interferon genes. (377 aa) |
| | LRRK2 | Leucine rich repeat kinase 2. (2527 aa) |
| | TRIM8 | Tripartite motif containing 8. (551 aa) |
| | SCFD1 | Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (644 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | QSOX1 | Sulfhydryl oxidase. (858 aa) |
| | SOGA3 | Uncharacterized protein. (986 aa) |
| | MTCL1 | Microtubule crosslinking factor 1. (2023 aa) |
| | FEZ1 | Fasciculation and elongation protein zeta 1. (439 aa) |
| | DRAM1 | Uncharacterized protein. (405 aa) |
| | BMF | Bcl2 modifying factor. (287 aa) |
| | TPCN2 | Two pore segment channel 2. (757 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1459 aa) |
| | LOC101081743 | Myotubularin phosphatase domain-containing protein. (560 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TSPO | Uncharacterized protein. (257 aa) |
| | TRIM65 | Tripartite motif containing 65. (520 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (428 aa) |
| | SESN3 | Sestrin 3. (492 aa) |
| | ATF6 | Activating transcription factor 6. (669 aa) |
| | LOC101085538 | Carboxypeptidase; Belongs to the peptidase S10 family. (497 aa) |
| | DCAF12L2 | DDB1 and CUL4 associated factor 12 like 2. (457 aa) |
| | RAB3GAP1 | RAB3 GTPase activating protein catalytic subunit 1. (1028 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | CPTP | Ceramide-1-phosphate transfer protein. (214 aa) |
| | HDAC6 | Histone deacetylase 6. (1178 aa) |
| | POLDIP2 | DNA polymerase delta interacting protein 2. (439 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa) |
| | FEZ2 | Fasciculation and elongation protein zeta 2. (383 aa) |
| | FLCN | Uncharacterized protein. (579 aa) |
| | DCAF12L1 | DDB1 and CUL4 associated factor 12 like 1. (457 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3659 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa) |
| | XBP1 | X-box binding protein 1. (383 aa) |
| | SCOC | Short coiled-coil protein. (175 aa) |
| | SESN1 | Sestrin 1. (551 aa) |
| | DEPDC5 | DEP domain containing 5. (1602 aa) |
| | LARP1 | La ribonucleoprotein domain family member 1. (1102 aa) |
| | ENSFCAP00000040884 | Uncharacterized protein. (85 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa) |
| | DEPP1 | DEPP1 autophagy regulator. (208 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | RNF41 | Ring finger protein 41. (317 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | FOXO1 | Forkhead box O1. (662 aa) |
| | TFEB | Transcription factor EB. (478 aa) |
| | TRIM21 | Tripartite motif containing 21. (469 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | JMJD8 | WD repeat domain 24. (790 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (283 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa) |
| | MFSD8 | Major facilitator superfamily domain containing 8. (522 aa) |
| | WDR41 | WD repeat domain 41. (495 aa) |
| | ATG101 | Autophagy related 101. (344 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (357 aa) |
| | CISD1 | CDGSH iron sulfur domain 1. (165 aa) |
| | RUBCN | Rubicon autophagy regulator. (1014 aa) |
| | PRAF2 | WD repeat domain 45. (361 aa) |
| | MTMR4 | Myotubularin related protein 4. (1209 aa) |
| | RAB3GAP2 | RAB3 GTPase activating non-catalytic protein subunit 2. (1393 aa) |
| | TPCN1 | Two pore segment channel 1. (928 aa) |
