BCL2 apoptosis regulator.

Beclin 1.

BCL2 apoptosis regulator.

Bcl2 modifying factor.

BCL2 apoptosis regulator.

Heme oxygenase 1.

BCL2 apoptosis regulator.

Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]

BCL2 apoptosis regulator.

Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]

BCL2 apoptosis regulator.

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).

BCL2 apoptosis regulator.

Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.

BCL2 apoptosis regulator.

PTEN induced kinase 1.

BCL2 apoptosis regulator.

Signal transducer and activator of transcription.

BCL2 apoptosis regulator.

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]

Beclin 1.

BCL2 apoptosis regulator.

Beclin 1.

Heme oxygenase 1.

Beclin 1.

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).

Beclin 1.

Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.

Beclin 1.

PTEN induced kinase 1.

Beclin 1.

Rubicon autophagy regulator.

Beclin 1.

Signal transducer and activator of transcription.

Beclin 1.

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]

Bcl2 modifying factor.

BCL2 apoptosis regulator.

Bcl2 modifying factor.

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).