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VPS13D VPS13D HIF1A HIF1A IL4 IL4 NPRL2 NPRL2 RNF152 RNF152 CD4H9orf72 CD4H9orf72 SPTLC1 SPTLC1 LRRK2 LRRK2 STING1 STING1 CDK16 CDK16 PINK1 PINK1 MID2 MID2 ATG2A ATG2A ATG16L1 ATG16L1 ULK1 ULK1 SUPT5H SUPT5H RB1CC1 RB1CC1 FBXO7 FBXO7 KDR KDR SNX18 SNX18 TRIM27 TRIM27 GSK3A GSK3A FOXO3 FOXO3 TRIM6 TRIM6 SH3GLB1 SH3GLB1 CCNY CCNY LOC101089184 LOC101089184 PRKAA1 PRKAA1 TSC2 TSC2 PRKAA2 PRKAA2 MAPK3 MAPK3 TPCN1 TPCN1 RAB3GAP2 RAB3GAP2 PRAF2 PRAF2 ATG101 ATG101 ROCK1 ROCK1 JMJD8 JMJD8 NOD1 NOD1 TRIM21 TRIM21 IFNG IFNG ZC3H12A ZC3H12A NOD2 NOD2 ADRB2 ADRB2 UFL1 UFL1 TRIML1 TRIML1 SNX30 SNX30 ENDOG ENDOG DAPK1 DAPK1 PAFAH1B2 PAFAH1B2 PRKD1 PRKD1 SIRT1 SIRT1 LOC101092021 LOC101092021 TRIM5 TRIM5 BECN1 BECN1 AMBRA1 AMBRA1 ATG13 ATG13 STK11 STK11 TRIM68 TRIM68 RIPK2 RIPK2 TP53INP1 TP53INP1 WAC WAC TRIML2 TRIML2 PLEKHF1 PLEKHF1 TRIM32 TRIM32 BAG3 BAG3 RALB RALB DCN DCN TRIM38 TRIM38 SNX4 SNX4 HMOX1 HMOX1 RUFY4 RUFY4 BNIP3 BNIP3 CALCOCO2 CALCOCO2 PIP4K2C PIP4K2C SPTLC2 SPTLC2 WIPI1 WIPI1 SVIP SVIP RNF31 RNF31 TMEM59 TMEM59 SH3BP4 SH3BP4 HMGB1 HMGB1 ENSFCAP00000057195 ENSFCAP00000057195 SNX7 SNX7 SESN2 SESN2 TRIM8 TRIM8 TBK1 TBK1 FYCO1 FYCO1 TRIM65 TRIM65 SESN3 SESN3 ATF6 ATF6 RAB3GAP1 RAB3GAP1 PIP4K2B PIP4K2B PRKN PRKN FLCN FLCN SCOC SCOC SESN1 SESN1 SMCR8 SMCR8 DEPDC5 DEPDC5 LARP1 LARP1 ENSFCAP00000040884 ENSFCAP00000040884 KAT5 KAT5 TP53INP2 TP53INP2 FOXO1 FOXO1 TFEB TFEB PIP4K2A PIP4K2A NPRL3 NPRL3 LRSAM1 LRSAM1 TRIM13 TRIM13 HTT HTT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS13DVacuolar protein sorting 13 homolog D. (4389 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
RNF152Ring finger protein 152. (203 aa)
CD4H9orf72Chromosome D4 C9orf72 homolog. (481 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
STING1Stimulator of interferon genes. (377 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
PINK1PTEN induced kinase 1. (581 aa)
MID2Midline 2. (735 aa)
ATG2AAutophagy related 2A. (1928 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
FBXO7F-box protein 7. (444 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
SNX18Sorting nexin. (624 aa)
TRIM27Tripartite motif containing 27. (513 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
FOXO3Forkhead box O3. (672 aa)
TRIM6Tripartite motif containing 6. (487 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (401 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
LOC101089184Uncharacterized protein. (775 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
TSC2TSC complex subunit 2. (1806 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TPCN1Two pore segment channel 1. (928 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1393 aa)
PRAF2WD repeat domain 45. (361 aa)
ATG101Autophagy related 101. (344 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
JMJD8WD repeat domain 24. (790 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
TRIM21Tripartite motif containing 21. (469 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
UFL1UFM1 specific ligase 1. (792 aa)
TRIML1Tripartite motif family like 1. (474 aa)
SNX30Sorting nexin family member 30. (449 aa)
ENDOGEndonuclease. (298 aa)
DAPK1Death associated protein kinase 1. (1429 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
SIRT1Sirtuin 1. (745 aa)
LOC101092021Uncharacterized protein. (235 aa)
TRIM5Uncharacterized protein. (486 aa)
BECN1Beclin 1. (448 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
TRIM68Tripartite motif containing 68. (485 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
TRIML2Tripartite motif family like 2. (442 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (280 aa)
TRIM32Uncharacterized protein. (669 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
RALBRAS like proto-oncogene B. (206 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
TRIM38Tripartite motif containing 38. (514 aa)
SNX4Sorting nexin 4. (459 aa)
HMOX1Heme oxygenase 1. (404 aa)
RUFY4RUN and FYVE domain containing 4. (697 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (474 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (435 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (694 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (470 aa)
SVIPUncharacterized protein. (124 aa)
RNF31Uncharacterized protein. (1081 aa)
TMEM59Uncharacterized protein. (335 aa)
SH3BP4SH3 domain binding protein 4. (1056 aa)
HMGB1Uncharacterized protein. (233 aa)
ENSFCAP00000057195Uncharacterized protein. (34 aa)
SNX7Sorting nexin 7. (513 aa)
SESN2Sestrin 2. (516 aa)
TRIM8Tripartite motif containing 8. (551 aa)
TBK1TANK binding kinase 1. (729 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1459 aa)
TRIM65Tripartite motif containing 65. (520 aa)
SESN3Sestrin 3. (492 aa)
ATF6Activating transcription factor 6. (669 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1028 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
FLCNUncharacterized protein. (579 aa)
SCOCShort coiled-coil protein. (175 aa)
SESN1Sestrin 1. (551 aa)
SMCR8SMCR8-C9orf72 complex subunit. (938 aa)
DEPDC5DEP domain containing 5. (1602 aa)
LARP1La ribonucleoprotein domain family member 1. (1102 aa)
ENSFCAP00000040884Uncharacterized protein. (85 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
FOXO1Forkhead box O1. (662 aa)
TFEBTranscription factor EB. (478 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (421 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
TRIM13Tripartite motif containing 13. (409 aa)
HTTHuntingtin. (3140 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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