STRINGSTRING
C3AR1 C3AR1 CYP1B1 CYP1B1 C5AR1 C5AR1 RORA RORA ARNT ARNT SULF1 SULF1 IL6 IL6 ENSFCAP00000048958 ENSFCAP00000048958 IL1A IL1A EIF2AK3 EIF2AK3 IL6ST IL6ST ATF4 ATF4 IL1B IL1B HIF1A HIF1A FLT4 FLT4 NODAL NODAL C5 C5 SULF2 SULF2 CXCL17 CXCL17 NOX1 NOX1 CCBE1 CCBE1 HPSE HPSE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
RORARAR related orphan receptor A. (523 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (790 aa)
SULF1Sulfatase 1. (1116 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
ENSFCAP00000048958BHLH domain-containing protein. (109 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
ATF4Activating transcription factor 4. (352 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
NODALNodal growth differentiation factor. (348 aa)
C5Complement C5. (1680 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. (893 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
NOX1NADPH oxidase 1. (564 aa)
CCBE1Collagen and calcium binding EGF domains 1. (440 aa)
HPSEHeparanase. (543 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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