STRINGSTRING
MTOR MTOR BCL9L BCL9L ENG ENG CTNNB1 CTNNB1 CRB2 CRB2 TGFB1 TGFB1 IL1B IL1B LOXL3 LOXL3 PDPN PDPN EZH2 EZH2 TGFB1I1 TGFB1I1 SNAI1 SNAI1 LOXL2 LOXL2 TBX20 TBX20 TGFB3 TGFB3 NOTCH1 NOTCH1 IL6 IL6 FERMT2 FERMT2 AXIN2 AXIN2 GLIPR2 GLIPR2 ENSFCAP00000029786 ENSFCAP00000029786 BMP2 BMP2 SMAD4 SMAD4 ALX1 ALX1 TGFB2 TGFB2 SMAD3 SMAD3 WWTR1 WWTR1 ZNF703 ZNF703 LRG1 LRG1 BAMBI BAMBI TGFBR1 TGFBR1 DAB2 DAB2 LEF1 LEF1 TCF7L2 TCF7L2 BMP4 BMP4 ENSFCAP00000055271 ENSFCAP00000055271
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BCL9LBCL9 like. (1393 aa)
ENGEndoglin. (654 aa)
CTNNB1Catenin beta 1. (783 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
LOXL3Lysyl oxidase like 3. (974 aa)
PDPNPodoplanin. (163 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LOXL2Lysyl oxidase like 2. (773 aa)
TBX20T-box transcription factor 20. (480 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NOTCH1Notch receptor 1. (2543 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
FERMT2Fermitin family member 2. (706 aa)
AXIN2Axin 2. (841 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
ENSFCAP00000029786Uncharacterized protein. (76 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ALX1ALX homeobox 1. (326 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ZNF703Zinc finger protein 703. (592 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (346 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
DAB2DAB adaptor protein 2. (769 aa)
LEF1Lymphoid enhancer binding factor 1. (415 aa)
TCF7L2Transcription factor 7 like 2. (673 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENSFCAP00000055271PID domain-containing protein. (114 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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