STRINGSTRING
WNT1 WNT1 ACER2 ACER2 SPRY4 SPRY4 MELTF MELTF BCL6 BCL6 RCC2 RCC2 PIK3R1 PIK3R1 THBS1 THBS1 TBCD TBCD ANGPT2 ANGPT2 SPOCK1 SPOCK1 PTEN PTEN CORO2A CORO2A SEMA3E SEMA3E AP1AR AP1AR HOXA7 HOXA7 NOTCH1 NOTCH1 APOD APOD CORO1C CORO1C ACTN4 ACTN4 FZD7 FZD7 CASK CASK ITGB1BP1 ITGB1BP1 FZD4 FZD4 MYOC MYOC ACVRL1 ACVRL1 PHLDB2 PHLDB2 RASA1 RASA1 EFNA5 EFNA5 DMTN DMTN ARHGAP6 ARHGAP6 FBLN1 FBLN1 AJAP1 AJAP1 ADAM15 ADAM15 NF1 NF1 JAG1 JAG1 KANK1 KANK1 PLET1 PLET1 CORO2B CORO2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (744 aa)
BCL6BCL6 transcription repressor. (745 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
THBS1Thrombospondin 1. (1170 aa)
TBCDTubulin folding cofactor D. (1189 aa)
ANGPT2Angiopoietin 2. (494 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (441 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (515 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
HOXA7Homeobox A7. (234 aa)
NOTCH1Notch receptor 1. (2543 aa)
APODApolipoprotein D. (189 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
ACTN4Actinin alpha 4. (933 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (935 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (213 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (498 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1247 aa)
RASA1RAS p21 protein activator 1. (1039 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
DMTNDematin actin binding protein. (405 aa)
ARHGAP6Rho GTPase activating protein 6. (455 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
AJAP1Adherens junctions associated protein 1. (431 aa)
ADAM15ADAM metallopeptidase domain 15. (869 aa)
NF1Neurofibromin 1. (2856 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
KANK1KN motif and ankyrin repeat domains 1. (1366 aa)
PLET1Uncharacterized protein. (278 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (501 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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