57 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADCK5	AarF domain containing kinase 5. (580 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
	FBXO7	F-box protein 7. (444 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	MIEF1	Mitochondrial elongation factor 1. (463 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	MLLT11	MLLT11 transcription factor 7 cofactor. (90 aa)
	CIDEB	Cell death inducing DFFA like effector b. (221 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (360 aa)
	DDHD2	DDHD domain containing 2. (670 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
	M3X8L9_FELCA	Uncharacterized protein. (306 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (204 aa)
	MIEF2	Mitochondrial elongation factor 2. (453 aa)
	SPIRE1	Spire type actin nucleation factor 1. (810 aa)
	ADCK1	AarF domain containing kinase 1. (523 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (803 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
	GSK3B	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	ZDHHC6	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
	ZNF205	Zinc finger protein 205. (551 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	BBC3	Uncharacterized protein. (193 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	MGARP	Mitochondria localized glutamic acid rich protein. (241 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	DDHD1	DDHD domain containing 1. (896 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	TNFSF10	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
	RALBP1	RalA binding protein 1. (659 aa)
	MCU	Mitochondrial calcium uniporter. (475 aa)
	SSBP1	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (349 aa)
	PGAM5	Uncharacterized protein. (303 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (803 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
	MFF	Mitochondrial fission factor. (357 aa)
	BOK	BCL2 family apoptosis regulator BOK. (320 aa)
	BIK	Uncharacterized protein. (245 aa)
	STOML2	Stomatin like 2. (425 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
	FAM162A	Family with sequence similarity 162 member A. (167 aa)
	BNIP3	BCL2 interacting protein 3. (187 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1068 aa)
	ENDOG	Endonuclease. (298 aa)
	PLAUR	Plasminogen activator, urokinase receptor. (335 aa)
	HTT	Huntingtin. (3140 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4389 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	PDCD5	Programmed cell death 5. (197 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (258 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	PINK1	ENSFCAP00000012643	ENSFCAP00000000737	Autophagy and beclin 1 regulator 1.	PTEN induced kinase 1.	0.522
AMBRA1	PRKN	ENSFCAP00000012643	ENSFCAP00000043123	Autophagy and beclin 1 regulator 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.955
BAD	BAX	ENSFCAP00000047559	ENSFCAP00000000237	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.840
BAD	BCL2L11	ENSFCAP00000047559	ENSFCAP00000049779	BCL2 associated agonist of cell death.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.888
BAD	BID	ENSFCAP00000047559	ENSFCAP00000055705	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.798
BAD	BOK	ENSFCAP00000047559	ENSFCAP00000057223	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	HRK	ENSFCAP00000047559	ENSFCAP00000050054	BCL2 associated agonist of cell death.	Activator of apoptosis harakiri; Promotes apoptosis.	0.401
BAX	BAD	ENSFCAP00000000237	ENSFCAP00000047559	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death.	0.840
BAX	BBC3	ENSFCAP00000000237	ENSFCAP00000046125	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.742
BAX	BCL2L11	ENSFCAP00000000237	ENSFCAP00000049779	BCL2 associated X, apoptosis regulator.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.969
BAX	BID	ENSFCAP00000000237	ENSFCAP00000055705	BCL2 associated X, apoptosis regulator.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.998
BAX	PMAIP1	ENSFCAP00000000237	ENSFCAP00000049753	BCL2 associated X, apoptosis regulator.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.717
BAX	PPIF	ENSFCAP00000000237	ENSFCAP00000025399	BCL2 associated X, apoptosis regulator.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.464
BAX	PRKN	ENSFCAP00000000237	ENSFCAP00000043123	BCL2 associated X, apoptosis regulator.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.921
BAX	TP53	ENSFCAP00000000237	ENSFCAP00000045749	BCL2 associated X, apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.411
BBC3	BAX	ENSFCAP00000046125	ENSFCAP00000000237	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.742
BBC3	BCL2L11	ENSFCAP00000046125	ENSFCAP00000049779	Uncharacterized protein.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.662
BBC3	BID	ENSFCAP00000046125	ENSFCAP00000055705	Uncharacterized protein.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.924
BBC3	BOK	ENSFCAP00000046125	ENSFCAP00000057223	Uncharacterized protein.	BCL2 family apoptosis regulator BOK.	0.586
BBC3	HRK	ENSFCAP00000046125	ENSFCAP00000050054	Uncharacterized protein.	Activator of apoptosis harakiri; Promotes apoptosis.	0.538