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| | CLSPN | Claspin. (1327 aa) |
| | NEK11 | NIMA related kinase 11. (654 aa) |
| | IK | IK cytokine. (555 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (944 aa) |
| | FBXO43 | F-box protein 43. (700 aa) |
| | CCNF | Cyclin F; Belongs to the cyclin family. (848 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa) |
| | CTDSPL | CTD small phosphatase like. (283 aa) |
| | CTDSP1 | CTD small phosphatase 1. (261 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (851 aa) |
| | INTS3 | Integrator complex subunit 3. (1012 aa) |
| | PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa) |
| | PML | Promyelocytic leukemia. (876 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (344 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (916 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (266 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | BLM | BLM RecQ like helicase. (1428 aa) |
| | DMRT1 | Doublesex and mab-3 related transcription factor 1. (378 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | RBM14 | RNA binding motif protein 14. (669 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (955 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa) |
| | INTS7 | Integrator complex subunit 7. (962 aa) |
| | KNTC1 | Kinetochore associated 1. (2207 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | NACC2 | NACC family member 2. (581 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (504 aa) |
| | SUSD2 | Sushi domain containing 2. (823 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | CDC5L | Cell division cycle 5 like. (802 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | FBXO7 | F-box protein 7. (444 aa) |
| | E2F8 | E2F transcription factor 8. (864 aa) |
| | E2F7 | E2F transcription factor 7. (910 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | NOP53 | NOP53 ribosome biogenesis factor. (485 aa) |
| | FANCD2 | FA complementation group D2. (1450 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (370 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | TIMELESS | Timeless circadian regulator. (1211 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1482 aa) |
| | NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (589 aa) |
| | TMEM67 | Transmembrane protein 67. (994 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (604 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (612 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1884 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1086 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | DCUN1D3 | Defective in cullin neddylation 1 domain containing 3. (304 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | NEK2 | NIMA related kinase 2. (444 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (646 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | ATRX | ATRX chromatin remodeler. (2486 aa) |
| | CRLF3 | Cytokine receptor like factor 3. (498 aa) |
| | TTK | TTK protein kinase. (856 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (754 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (722 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1653 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | TAOK3 | TAO kinase 3. (914 aa) |
| | NABP1 | Nucleic acid binding protein 1. (219 aa) |
| | HASPIN | Histone H3 associated protein kinase. (782 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa) |
| | EEF1AKNMT | EEF1A lysine and N-terminal methyltransferase. (699 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | FBXO5 | F-box protein 5. (451 aa) |
| | MDM1 | Mdm1 nuclear protein. (729 aa) |
| | CTDSP2 | CTD small phosphatase 2. (271 aa) |
| | NANOS2 | Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | TRIM60 | Tripartite motif containing 60. (471 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa) |
| | GPNMB | Glycoprotein nmb. (568 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa) |
| | FHL1 | Four and a half LIM domains 1. (366 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (237 aa) |
| | LOC101098376 | Uncharacterized protein. (473 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1484 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (970 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | HINFP | Histone H4 transcription factor. (500 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | LOC101098728 | Uncharacterized protein. (289 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (768 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | STK33 | Serine/threonine kinase 33. (521 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | FOXO4 | Forkhead box O4. (515 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (221 aa) |
| | NSUN2 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (912 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (451 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | ZFYVE19 | Zinc finger FYVE-type containing 19. (400 aa) |
| | LIF | LIF interleukin 6 family cytokine. (204 aa) |
| | TIPRL | TOR signaling pathway regulator. (313 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1143 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4108 aa) |
| | KANK2 | KN motif and ankyrin repeat domains 2. (857 aa) |
| | WAPL | WAPL cohesin release factor. (1196 aa) |
| | ENSFCAP00000037485 | Uncharacterized protein. (183 aa) |
| | JADE1 | Jade family PHD finger 1. (1001 aa) |
| | TOM1L2 | Target of myb1 like 2 membrane trafficking protein. (551 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | ENSFCAP00000038408 | Uncharacterized protein. (249 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1139 aa) |
| | CCP110 | Centriolar coiled-coil protein 110. (1009 aa) |
| | APC | APC regulator of WNT signaling pathway. (2874 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | ZNF207 | Zinc finger protein 207. (538 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | FBXO31 | F-box protein 31. (643 aa) |
| | BABAM1 | Uncharacterized protein. (334 aa) |
| | MIIP | Migration and invasion inhibitory protein. (460 aa) |
| | GML | Glycosylphosphatidylinositol anchored molecule like. (151 aa) |
| | TPRA1 | Transmembrane protein adipocyte associated 1. (439 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (641 aa) |
| | TRIM75P | Tripartite motif containing 75, pseudogene. (469 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2498 aa) |
| | C10orf99 | Chromosome 10 open reading frame 99. (81 aa) |
| | FOXN3 | Forkhead box N3. (488 aa) |
| | CDK2AP2 | Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (127 aa) |
| | C10orf90 | Chromosome 10 open reading frame 90. (655 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (264 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | TOM1L1 | Target of myb1 like 1 membrane trafficking protein. (521 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (705 aa) |
| | SYF2 | Uncharacterized protein. (246 aa) |
| | MAP3K20 | Uncharacterized protein. (800 aa) |
| | GPR132 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | CDK5RAP2 | CDK5 regulatory subunit associated protein 2. (1856 aa) |
| | CHEK2 | Checkpoint kinase 2. (569 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ATF5 | Activating transcription factor 5. (280 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (840 aa) |
| | IZUMO4 | IZUMO family member 4. (229 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (415 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (1012 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | MRNIP | MRN complex interacting protein. (348 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | LOC111559734 | Bone morphogenetic protein 7. (426 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (448 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa) |
| | TRIM39 | Tripartite motif containing 39. (517 aa) |
| | CHFR | Checkpoint with forkhead and ring finger domains. (833 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (408 aa) |
| | ENSFCAP00000052534 | Reverse transcriptase domain-containing protein. (665 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (588 aa) |
| | NKX3-1 | NK3 homeobox 1. (231 aa) |
| | ENSFCAP00000053448 | Uncharacterized protein. (182 aa) |
| | MTBP | MDM2 binding protein. (911 aa) |
| | ENSFCAP00000054710 | Reverse transcriptase domain-containing protein. (817 aa) |
| | PIDD1 | P53-induced death domain protein 1. (940 aa) |
| | NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (641 aa) |
| | MUC1 | Uncharacterized protein. (931 aa) |
| | PTTG1 | Uncharacterized protein. (213 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa) |
| | ENSFCAP00000055731 | Reverse transcriptase domain-containing protein. (713 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (726 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (579 aa) |
| | AVEN | Apoptosis and caspase activation inhibitor. (356 aa) |
| | ENSFCAP00000056200 | MOEP19 domain-containing protein. (399 aa) |
| | DONSON | Downstream neighbor of SON. (612 aa) |
| | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B. (1062 aa) |
| | ENSFCAP00000057489 | Uncharacterized protein. (192 aa) |
| | RINT1 | RAD50 interactor 1. (794 aa) |
| | GAS1 | Growth arrest specific 1. (369 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1817 aa) |
| | ENSFCAP00000059078 | Reverse transcriptase domain-containing protein. (240 aa) |
| | CCDC84 | Coiled-coil domain containing 84. (437 aa) |
| | TMPRSS5 | Zw10 kinetochore protein. (848 aa) |
| | ENSFCAP00000060774 | Protein kinase domain-containing protein. (78 aa) |
| | SKA2 | Tripartite motif containing 37. (987 aa) |
| | ENSFCAP00000061058 | Reverse transcriptase domain-containing protein. (767 aa) |
| | ENSFCAP00000061110 | TGF_BETA_2 domain-containing protein. (362 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1551 aa) |
| | ZWILCH | Zwilch kinetochore protein. (630 aa) |
| | HORMAD1 | HORMA domain containing 1. (413 aa) |
| | NME6 | Nucleoside diphosphate kinase. (193 aa) |
