STRINGSTRING
MECP2 MECP2 MTOR MTOR GPR37L1 GPR37L1 NR2E1 NR2E1 SERPINE2 SERPINE2 TREM2 TREM2 SOX10 SOX10 TNFRSF1B TNFRSF1B NF2 NF2 TGFB1 TGFB1 GFAP GFAP IL1B IL1B LRP2 LRP2 UFL1 UFL1 VEGFC VEGFC EGR2 EGR2 EZH2 EZH2 RNF112 RNF112 IL6ST IL6ST PRKCH PRKCH KRAS KRAS CLCF1 CLCF1 F2 F2 NOTCH1 NOTCH1 ASPA ASPA GSX2 GSX2 IL6 IL6 PTN PTN IL34 IL34 RB1 RB1 NKX6-1 NKX6-1 PRKCI PRKCI DLX2 DLX2 OLIG2 OLIG2 BMP2 BMP2 LIF LIF BIN1 BIN1 SOX8 SOX8 ATOH1 ATOH1 HES5 HES5 ZNF365 ZNF365 TMEM98 TMEM98 PLAG1 PLAG1 TENM4 TENM4 TP53 TP53 NOG NOG NKX6-2 NKX6-2 LDLR LDLR DLX1 DLX1 TNF TNF HES1 HES1 NR1D1 NR1D1 NF1 NF1 SOX11 SOX11 NTN1 NTN1 ZNF488 ZNF488
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
GPR37L1G protein-coupled receptor 37 like 1. (551 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (484 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
SOX10SRY-box transcription factor 10. (604 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
NF2Neurofibromin 2. (596 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
LRP2LDL receptor related protein 2. (4646 aa)
UFL1UFM1 specific ligase 1. (792 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
EGR2Early growth response 2. (541 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
RNF112Ring finger protein 112. (629 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
KRASUncharacterized protein. (380 aa)
CLCF1Cardiotrophin like cytokine factor 1. (340 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
NOTCH1Notch receptor 1. (2543 aa)
ASPAAspartoacylase. (313 aa)
GSX2GS homeobox 2. (305 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
PTNPleiotrophin. (179 aa)
IL34Interleukin 34. (331 aa)
RB1RB transcriptional corepressor 1. (930 aa)
NKX6-1NK6 homeobox 1. (367 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
DLX2Distal-less homeobox 2. (331 aa)
OLIG2BHLH domain-containing protein. (519 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
BIN1Bridging integrator 1. (608 aa)
SOX8SRY-box 8. (883 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
ZNF365Zinc finger protein 365. (407 aa)
TMEM98Transmembrane protein 98. (226 aa)
PLAG1PLAG1 zinc finger. (499 aa)
TENM4Teneurin transmembrane protein 4. (2823 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NKX6-2NK6 homeobox 2. (285 aa)
LDLRLow density lipoprotein receptor. (866 aa)
DLX1Distal-less homeobox 1. (255 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (625 aa)
NF1Neurofibromin 1. (2856 aa)
SOX11Transcription factor SOX. (412 aa)
NTN1Netrin 1. (715 aa)
ZNF488Zinc finger protein 488. (233 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.