STRINGSTRING
TEX264 TEX264 ATG12 ATG12 UFL1 UFL1 CTSD CTSD EMC6 EMC6 SNAPIN SNAPIN GABARAPL2 GABARAPL2 NOD2 NOD2 UFC1 UFC1 ATP13A2 ATP13A2 RB1CC1 RB1CC1 ULK1 ULK1 RETREG2 RETREG2 ATG9A ATG9A ATG16L1 ATG16L1 RETREG3 RETREG3 PATL2 PATL2 ATG2A ATG2A BECN1 BECN1 ATG9B ATG9B HMOX1 HMOX1 UBXN2B UBXN2B RUFY4 RUFY4 CALCOCO2 CALCOCO2 KIAA1324 KIAA1324 ATG4B ATG4B ENSFCAP00000059015 ENSFCAP00000059015 UBXN2A UBXN2A WIPI1 WIPI1 ATG4D ATG4D MCOLN1 MCOLN1 WIPI2 WIPI2 VPS39 VPS39 SNX7 SNX7 UVRAG UVRAG TECPR1 TECPR1 HDAC10 HDAC10 CHMP7 CHMP7 VTI1B VTI1B AUP1 AUP1 MAP1LC3B MAP1LC3B GAA GAA NSFL1C NSFL1C RUBCNL RUBCNL EPG5 EPG5 CHMP6 CHMP6 RAB1A RAB1A ILRUN ILRUN TMEM41B TMEM41B TIGAR TIGAR GABARAPL1 GABARAPL1 UBXN6 UBXN6 CHMP5 CHMP5 CHMP2B CHMP2B ATG5 ATG5 ATG3 ATG3 PIP4K2B PIP4K2B TP53 TP53 ENSFCAP00000044926 ENSFCAP00000044926 PRKN PRKN SPATA33 SPATA33 LGALS8 LGALS8 ENSFCAP00000041779 ENSFCAP00000041779 ATG16L2 ATG16L2 PIK3R4 PIK3R4 MAP1LC3C MAP1LC3C ARFIP2 ARFIP2 TP53INP2 TP53INP2 TCIRG1 TCIRG1 EI24 EI24 VAMP8 VAMP8 ENSFCAP00000038726 ENSFCAP00000038726 NOD1 NOD1 ATG7 ATG7 MFSD8 MFSD8 ATG101 ATG101 PRAF2 PRAF2 RAB33B RAB33B ENSFCAP00000034738 ENSFCAP00000034738 RAB1B RAB1B LOC101095070 LOC101095070 MAPK3 MAPK3 CHMP4A CHMP4A CHMP1A CHMP1A VTI1A VTI1A PLEKHM1 PLEKHM1 PIP4K2A PIP4K2A VPS41 VPS41 NBR1 NBR1 CLN3 CLN3 LIX1 LIX1 OGT OGT ATG10 ATG10 LIX1L LIX1L MFN2 MFN2 PIK3C3 PIK3C3 UBA5 UBA5 PLAA PLAA TRAPPC8 TRAPPC8 CHMP4C CHMP4C ATP2A2 ATP2A2 MAP1LC3A MAP1LC3A WDR81 WDR81 GABARAP GABARAP ZFYVE26 ZFYVE26 PHB2 PHB2 STX12 STX12 DDRGK1 DDRGK1 MTM1 MTM1 AP4M1 AP4M1 TMEM74 TMEM74 STBD1 STBD1 PACS2 PACS2 ATG14 ATG14 RAB7A RAB7A VPS33A VPS33A TP53INP1 TP53INP1 RIPK2 RIPK2 M3WPJ7_FELCA M3WPJ7_FELCA PJVK PJVK STX17 STX17 SMURF1 SMURF1 PIK3C2B PIK3C2B ZFYVE1 ZFYVE1 SQSTM1 SQSTM1 ATG13 ATG13 AMBRA1 AMBRA1 LOC101094500 LOC101094500 ATG2B ATG2B SNX30 SNX30 MTOR MTOR PINK1 PINK1 GBA GBA VCP VCP STING1 STING1 SNX14 SNX14 VPS16 VPS16 WDR45B WDR45B WDFY3 WDFY3 CHMP2A CHMP2A VMP1 VMP1 ULK3 ULK3 LAMP2 LAMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
UFL1UFM1 specific ligase 1. (792 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa)
EMC6ER membrane protein complex subunit 6. (110 aa)
SNAPINSNAP associated protein. (229 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
UFC1Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1161 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
RETREG2Reticulophagy regulator family member 2. (546 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (998 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
RETREG3Reticulophagy regulator family member 3. (466 aa)
PATL2SPG11 vesicle trafficking associated, spatacsin. (2444 aa)
ATG2AAutophagy related 2A. (1928 aa)
BECN1Beclin 1. (448 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
HMOX1Heme oxygenase 1. (404 aa)
UBXN2BUBX domain protein 2B. (440 aa)
RUFY4RUN and FYVE domain containing 4. (697 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (474 aa)
KIAA1324KIAA1324. (1091 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (578 aa)
ENSFCAP00000059015Uncharacterized protein. (263 aa)
UBXN2AUBX domain protein 2A. (265 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (470 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (475 aa)
MCOLN1Mucolipin 1. (620 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (468 aa)
VPS39VPS39 subunit of HOPS complex. (956 aa)
SNX7Sorting nexin 7. (513 aa)
UVRAGUV radiation resistance associated. (718 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1201 aa)
HDAC10Histone deacetylase 10. (546 aa)
CHMP7Charged multivesicular body protein 7. (456 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (247 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (492 aa)
MAP1LC3BUncharacterized protein. (309 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (1002 aa)
NSFL1CNSFL1 cofactor. (470 aa)
RUBCNLRubicon like autophagy enhancer. (677 aa)
EPG5Ectopic P-granules autophagy protein 5 homolog. (2616 aa)
CHMP6Charged multivesicular body protein 6. (263 aa)
RAB1ARAB1A, member RAS oncogene family. (238 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (291 aa)
TMEM41BTransmembrane protein 41B. (291 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
GABARAPL1GABA type A receptor associated protein like 1. (151 aa)
UBXN6UBX domain protein 6. (502 aa)
CHMP5Charged multivesicular body protein 5. (372 aa)
CHMP2BCharged multivesicular body protein 2B. (227 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ATG3Autophagy-related protein 3. (333 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
ENSFCAP00000044926Uncharacterized protein. (107 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
SPATA33Uncharacterized protein. (96 aa)
LGALS8Galectin. (376 aa)
ENSFCAP00000041779Uncharacterized protein. (112 aa)
ATG16L2Autophagy related 16 like 2. (617 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
MAP1LC3CUncharacterized protein. (141 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (374 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (954 aa)
EI24Uncharacterized protein. (340 aa)
VAMP8Vesicle associated membrane protein 8. (99 aa)
ENSFCAP00000038726Uncharacterized protein. (134 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa)
MFSD8Major facilitator superfamily domain containing 8. (522 aa)
ATG101Autophagy related 101. (344 aa)
PRAF2WD repeat domain 45. (361 aa)
RAB33BUncharacterized protein. (488 aa)
ENSFCAP00000034738Uncharacterized protein. (249 aa)
RAB1BRAB1B, member RAS oncogene family. (201 aa)
LOC101095070Uncharacterized protein. (141 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CHMP4ACharged multivesicular body protein 4A. (220 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (267 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1066 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (421 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
NBR1NBR1 autophagy cargo receptor. (968 aa)
CLN3Battenin. (438 aa)
LIX1Uncharacterized protein. (314 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ATG10Autophagy related 10. (353 aa)
LIX1LLimb and CNS expressed 1 like. (336 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
UBA5Ubiquitin like modifier activating enzyme 5. (404 aa)
PLAAPhospholipase A2 activating protein. (796 aa)
TRAPPC8Trafficking protein particle complex 8. (1435 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
WDR81WD repeat domain 81. (1943 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2540 aa)
PHB2Prohibitin. (299 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
DDRGK1DDRGK domain containing 1. (340 aa)
MTM1Myotubularin 1. (603 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (460 aa)
TMEM74Transmembrane protein 74. (305 aa)
STBD1Starch binding domain 1. (361 aa)
PACS2Phosphofurin acidic cluster sorting protein 2. (902 aa)
ATG14Autophagy related 14. (510 aa)
RAB7AUncharacterized protein. (207 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
M3WPJ7_FELCAUncharacterized protein. (188 aa)
PJVKPejvakin. (352 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (790 aa)
SQSTM1Sequestosome 1. (443 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
LOC101094500Uncharacterized protein. (274 aa)
ATG2BAutophagy related 2B. (2114 aa)
SNX30Sorting nexin family member 30. (449 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PINK1PTEN induced kinase 1. (581 aa)
GBAGlucosylceramidase. (536 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (761 aa)
STING1Stimulator of interferon genes. (377 aa)
SNX14Sorting nexin 14. (1004 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
WDR45BWD repeat domain 45B. (344 aa)
WDFY3WD repeat and FYVE domain containing 3. (3527 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
VMP1Vacuole membrane protein 1. (406 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
LAMP2Lysosomal associated membrane protein 2. (470 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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