27 items (Felis catus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LZTS1	Leucine zipper tumor suppressor 1. (606 aa)
	RUBCN	Rubicon autophagy regulator. (1014 aa)
	RNF41	Ring finger protein 41. (317 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3659 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (383 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (439 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (428 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (439 aa)
	QSOX1	Sulfhydryl oxidase. (858 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (644 aa)
	UBQLN4	Ubiquilin 4. (608 aa)
	TMEM39A	Transmembrane protein 39A. (505 aa)
	TMEM39B	Transmembrane protein 39B. (512 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1407 aa)
	HMOX1	Heme oxygenase 1. (404 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	CLEC16A	C-type lectin domain containing 16A. (1045 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	BECN1	Beclin 1. (448 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	MTM1	Myotubularin 1. (603 aa)
	PHF23	PHD finger protein 23. (403 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (938 aa)
	CHMP4A	Charged multivesicular body protein 4A. (220 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BECN1	HMOX1	ENSFCAP00000012183	ENSFCAP00000062192	Beclin 1.	Heme oxygenase 1.	0.455
BECN1	MTOR	ENSFCAP00000012183	ENSFCAP00000000048	Beclin 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.766
BECN1	PINK1	ENSFCAP00000012183	ENSFCAP00000000737	Beclin 1.	PTEN induced kinase 1.	0.991
BECN1	RUBCN	ENSFCAP00000012183	ENSFCAP00000036427	Beclin 1.	Rubicon autophagy regulator.	0.914
BECN1	TP53	ENSFCAP00000012183	ENSFCAP00000045749	Beclin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.702
CLEC16A	RNF41	ENSFCAP00000010835	ENSFCAP00000039992	C-type lectin domain containing 16A.	Ring finger protein 41.	0.438
EHMT2	TP53	ENSFCAP00000061640	ENSFCAP00000045749	Euchromatic histone lysine methyltransferase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.834
HMOX1	BECN1	ENSFCAP00000062192	ENSFCAP00000012183	Heme oxygenase 1.	Beclin 1.	0.455
LRRK2	PINK1	ENSFCAP00000001684	ENSFCAP00000000737	Leucine rich repeat kinase 2.	PTEN induced kinase 1.	0.505
MTOR	BECN1	ENSFCAP00000000048	ENSFCAP00000012183	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Beclin 1.	0.766
MTOR	SMCR8	ENSFCAP00000000048	ENSFCAP00000024656	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	SMCR8-C9orf72 complex subunit.	0.479
MTOR	SMG1	ENSFCAP00000000048	ENSFCAP00000041785	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.549
MTOR	TP53	ENSFCAP00000000048	ENSFCAP00000045749	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.645
NUPR1	TP53	ENSFCAP00000011408	ENSFCAP00000045749	Nuclear protein 1, transcriptional regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.470
PINK1	BECN1	ENSFCAP00000000737	ENSFCAP00000012183	PTEN induced kinase 1.	Beclin 1.	0.991
PINK1	LRRK2	ENSFCAP00000000737	ENSFCAP00000001684	PTEN induced kinase 1.	Leucine rich repeat kinase 2.	0.505
PINK1	UBQLN4	ENSFCAP00000000737	ENSFCAP00000056101	PTEN induced kinase 1.	Ubiquilin 4.	0.484
RNF41	CLEC16A	ENSFCAP00000039992	ENSFCAP00000010835	Ring finger protein 41.	C-type lectin domain containing 16A.	0.438
RUBCN	BECN1	ENSFCAP00000036427	ENSFCAP00000012183	Rubicon autophagy regulator.	Beclin 1.	0.914
SCFD1	SEC22B	ENSFCAP00000055352	ENSFCAP00000020219	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.972