STRINGSTRING
MTHFD1 MTHFD1 STK3 STK3 CELSR1 CELSR1 ST14 ST14 CLUAP1 CLUAP1 PHACTR4 PHACTR4 SUFU SUFU GDF7 GDF7 SOX4 SOX4 BMP4 BMP4 RARG RARG SEMA4C SEMA4C BCL10 BCL10 IRX1 IRX1 OPA1 OPA1 WNT6 WNT6 LOC111556166 LOC111556166 LMO4 LMO4 TRAF6 TRAF6 DVL2 DVL2 NOG NOG SOX9 SOX9 PTCH1 PTCH1 ARHGAP35 ARHGAP35 GATA3 GATA3 IRX2 IRX2 HECTD1 HECTD1 TSC1 TSC1 CC2D2A CC2D2A ALDH1A2 ALDH1A2 GLMN GLMN HES5 HES5 MED12 MED12 PRKACB PRKACB SFRP2 SFRP2 LUZP1 LUZP1 LIAS LIAS COBL COBL SOX8 SOX8 PAX8 PAX8 SALL4 SALL4 SFRP1 SFRP1 SETD2 SETD2 KDM2B KDM2B GDNF GDNF BBS4 BBS4 FGF10 FGF10 CASP3 CASP3 IRX3 IRX3 PDX1 PDX1 GRSF1 GRSF1 TP63 TP63 JAG2 JAG2 MTHFR MTHFR CITED2 CITED2 SPINT2 SPINT2 FZD3 FZD3 FZD2 FZD2 OSR1 OSR1 STK4 STK4 RDH10 RDH10 RALA RALA KDF1 KDF1 IFT57 IFT57 LRRC1 LRRC1 GRHL3 GRHL3 HAND1 HAND1 PRICKLE1 PRICKLE1 RET RET SHROOM3 SHROOM3 TFAP2A TFAP2A MKS1 MKS1 PLXNB2 PLXNB2 TCTN1 TCTN1 IFT52 IFT52 MPP5 MPP5 ALDH1A3 ALDH1A3 MIB1 MIB1 PCDH8 PCDH8 PTK7 PTK7 LOC101084362 LOC101084362 KDM6A KDM6A TGFB1I1 TGFB1I1 CECR2 CECR2 HS2ST1 HS2ST1 VEGFC VEGFC DVL3 DVL3 DVL1 DVL1 VASP VASP LHX2 LHX2 LRP2 LRP2 ABL1 ABL1 CTHRC1 CTHRC1 FUZ FUZ MTHFD1L MTHFD1L HIF1A HIF1A TRIM71 TRIM71 KAT2A KAT2A TEAD2 TEAD2 NODAL NODAL SCRIB SCRIB WNT9B WNT9B TULP3 TULP3 SEC24B SEC24B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
STK3Serine/threonine kinase 3. (573 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3085 aa)
ST14Suppression of tumorigenicity 14. (861 aa)
CLUAP1Clusterin associated protein 1. (477 aa)
PHACTR4Phosphatase and actin regulator. (752 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
GDF7Growth differentiation factor 7. (455 aa)
SOX4Transcription factor SOX. (459 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
RARGRetinoic acid receptor gamma. (459 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
IRX1Iroquois homeobox 1. (485 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC111556166Uncharacterized protein. (804 aa)
LMO4LIM domain only 4. (165 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
DVL2Dishevelled segment polarity protein 2. (735 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9SRY-box transcription factor 9. (511 aa)
PTCH1Patched 1. (1451 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
GATA3GATA binding protein 3. (444 aa)
IRX2Iroquois homeobox 2. (456 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
TSC1TSC complex subunit 1. (1110 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1581 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
MED12Mediator complex subunit 12. (2278 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
LUZP1Leucine zipper protein 1. (1081 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
COBLCordon-bleu WH2 repeat protein. (395 aa)
SOX8SRY-box 8. (883 aa)
PAX8Paired box 8. (620 aa)
SALL4Spalt like transcription factor 4. (1058 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
KDM2BLysine demethylase 2B. (1264 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
BBS4Bardet-Biedl syndrome 4. (525 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
IRX3Iroquois homeobox 3. (502 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
GRSF1G-rich RNA sequence binding factor 1. (478 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1609 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
STK4Serine/threonine kinase 4. (487 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
RALARAS like proto-oncogene A. (206 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
IFT57Intraflagellar transport 57. (429 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
GRHL3Grainyhead like transcription factor 3. (602 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
PRICKLE1Prickle planar cell polarity protein 1. (830 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)
SHROOM3Shroom family member 3. (1994 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
MKS1MKS transition zone complex subunit 1. (627 aa)
PLXNB2Plexin B2. (1841 aa)
TCTN1Tectonic family member 1. (589 aa)
IFT52Intraflagellar transport 52. (446 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1016 aa)
PCDH8Protocadherin 8. (1062 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
LOC101084362Uncharacterized protein. (802 aa)
KDM6ALysine demethylase 6A. (1453 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
CECR2CECR2 histone acetyl-lysine reader. (1527 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (396 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
LHX2LIM homeobox 2. (406 aa)
LRP2LDL receptor related protein 2. (4646 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
CTHRC1Collagen triple helix repeat containing 1. (244 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
TRIM71Tripartite motif containing 71. (874 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
NODALNodal growth differentiation factor. (348 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1259 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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