STRINGSTRING
AMHR2 AMHR2 LGR4 LGR4 GNRHR GNRHR FSHR FSHR DCAF8 DCAF8 ENSFCAP00000061669 ENSFCAP00000061669 LGR6 LGR6 LHCGR LHCGR LGR5 LGR5 CMKLR1 CMKLR1 MCHR1 MCHR1 IGF1R IGF1R INSRR INSRR GPR1 GPR1 ADIPOR2 ADIPOR2 TSHR TSHR INSR INSR RXFP2 RXFP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (483 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (247 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
DCAF8DDB1 and CUL4 associated factor 8. (597 aa)
ENSFCAP00000061669WD_REPEATS_REGION domain-containing protein. (594 aa)
LGR6LRRNT domain-containing protein. (967 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
MCHR1Melanin concentrating hormone receptor 1. (353 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
INSRRTyrosine-protein kinase receptor. (1300 aa)
GPR1G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (396 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (770 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
RXFP2Relaxin family peptide receptor 2. (713 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.