STRINGSTRING
PLOD1 PLOD1 DEGS1 DEGS1 SAAL1 SAAL1 CYP1A2 CYP1A2 PHF8 PHF8 P3H2 P3H2 KDM8 KDM8 CYP17A1 CYP17A1 CYP4V2 CYP4V2 P3H4 P3H4 CYP24A1 CYP24A1 FMO3 FMO3 PHYH PHYH P3H3 P3H3 CYP21A2 CYP21A2 FTO FTO PLOD3 PLOD3 OGFOD2 OGFOD2 TPH2 TPH2 MICAL1 MICAL1 AKR1D1 AKR1D1 CYP4X1 CYP4X1 KDM4B KDM4B CYP26A1 CYP26A1 CYP7A1 CYP7A1 KDM4C KDM4C LOC101086441 LOC101086441 PAH PAH LOC101089816 LOC101089816 OGFOD1 OGFOD1 PHF2 PHF2 KDM6A KDM6A P4HTM P4HTM CYP26C1 CYP26C1 MOXD1 MOXD1 CYP7B1 CYP7B1 KDM3A KDM3A CYP11A1 CYP11A1 DBH DBH CYP2R1 CYP2R1 LOC101088802 LOC101088802 P3H1 P3H1 HMOX2 HMOX2 FMO4 FMO4 TET1 TET1 CYP2S1 CYP2S1 KDM5B KDM5B NOS3 NOS3 CYP27C1 CYP27C1 FADS1 FADS1 KDM1A KDM1A CYP27B1 CYP27B1 KDM4A KDM4A TTI2 TTI2 CYP2U1 CYP2U1 JMJD4 JMJD4 LOC101089311 LOC101089311 OGFOD3 OGFOD3 TYRP1 TYRP1 HSPBAP1 HSPBAP1 KDM6B KDM6B CYP8B1 CYP8B1 EGLN1 EGLN1 CYP19A1 CYP19A1 FADS3 FADS3 LOC101085921 LOC101085921 LOC109492144 LOC109492144 CYP2F1 CYP2F1 KDM7A KDM7A M3WWR9_FELCA M3WWR9_FELCA LOC101089804 LOC101089804 PTGS2 PTGS2 PLOD2 PLOD2 CYP20A1 CYP20A1 DEGS2 DEGS2 CYP4F22 CYP4F22 TYR TYR NOS1 NOS1 FADS2 FADS2 TPH1 TPH1 CYP51A1 CYP51A1 SQLE SQLE FADS6 FADS6 ALKBH4 ALKBH4 SCD5 SCD5 RSBN1 RSBN1 CCDC160 CCDC160 DOHH DOHH P4HB P4HB CH25H CH25H SCD SCD KMO KMO LOC101091046 LOC101091046 ENSFCAP00000025991 ENSFCAP00000025991 CYP4F8 CYP4F8 ALKBH2 ALKBH2 ASPH ASPH ENSFCAP00000027010 ENSFCAP00000027010 ENSFCAP00000028450 ENSFCAP00000028450 MSMO1 MSMO1 ALKBH1 ALKBH1 KDM5A KDM5A ENSFCAP00000032985 ENSFCAP00000032985 CYP39A1 CYP39A1 HIF1AN HIF1AN KDM2B KDM2B FMO2 FMO2 P4HA1 P4HA1 P4HA2 P4HA2 EGLN2 EGLN2 ALKBH8 ALKBH8 TET2-2 TET2-2 LOC105259649 LOC105259649 BBOX1 BBOX1 TET3 TET3 CYP3A131 CYP3A131 NOS2 NOS2 CYP2E2 CYP2E2 PTGIS PTGIS LOC101094994 LOC101094994 PPHLN1 PPHLN1 TH TH LOC105260134 LOC105260134 PAM PAM KDM5C KDM5C CYP1B1 CYP1B1 LOC101089561 LOC101089561 RIOX1 RIOX1 LOC109492298 LOC109492298 CYP26B1 CYP26B1 EGLN3 EGLN3 TMLHE TMLHE KDM2A KDM2A COQ6 COQ6 FMO5 FMO5 FMO1 FMO1 METTL26 METTL26 SC5D SC5D LOC101089396 LOC101089396 LOC101097790 LOC101097790 P4HA3 P4HA3 CYP4B1 CYP4B1 CYP2D6 CYP2D6 LOC101084948 LOC101084948 CYP3A132 CYP3A132 MICAL3 MICAL3 TET2 TET2 RIOX2 RIOX2 CMAH CMAH COQ7 COQ7 CYP27A1 CYP27A1 PHYHD1 PHYHD1 AGMO AGMO CRTAP CRTAP AKR1C3 AKR1C3 MRRF MRRF ENSFCAP00000056898 ENSFCAP00000056898 CYP2J2 CYP2J2 TBXAS1 TBXAS1 ALKBH5 ALKBH5 ENSFCAP00000059371 ENSFCAP00000059371 LOC101083281 LOC101083281 KDM1B KDM1B JMJD6 JMJD6 LOC101087695 LOC101087695 CCNDBP1 CCNDBP1 PIGS PIGS JMJD7 JMJD7 CYP46A1 CYP46A1 HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (727 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (336 aa)
SAAL1Serum amyloid A like 1. (475 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa)
PHF8PHD finger protein 8. (1024 aa)
P3H2Prolyl 3-hydroxylase 2. (707 aa)
KDM8Lysine demethylase 8. (414 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (576 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1. (492 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (357 aa)
P3H3Prolyl 3-hydroxylase 3. (736 aa)
CYP21A2Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (494 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (521 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (740 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (995 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (507 aa)
KDM4BLysine demethylase 4B. (1124 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
KDM4CLysine demethylase 4C. (1053 aa)
LOC101086441Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
PAHPhenylalanine hydroxylase. (465 aa)
LOC101089816Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
OGFOD12-oxoglutarate and iron dependent oxygenase domain containing 1. (545 aa)
PHF2PHD finger protein 2. (1088 aa)
KDM6ALysine demethylase 6A. (1453 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (493 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
MOXD1Monooxygenase DBH like 1. (619 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
KDM3ALysine demethylase 3A. (1324 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
DBHDopamine beta-hydroxylase. (610 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
LOC101088802Uncharacterized protein. (944 aa)
P3H1Prolyl 3-hydroxylase 1. (776 aa)
HMOX2Heme oxygenase 2. (316 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (565 aa)
TET1Tet methylcytosine dioxygenase 1. (2142 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (493 aa)
KDM5BLysine demethylase 5B. (1544 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
FADS1Fatty acid desaturase 1. (360 aa)
KDM1ALysine demethylase 1A. (944 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
KDM4ALysine demethylase 4A. (1067 aa)
TTI2TELO2 interacting protein 2. (507 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (544 aa)
JMJD4Jumonji domain containing 4. (426 aa)
LOC101089311Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
OGFOD32-oxoglutarate and iron dependent oxygenase domain containing 3. (315 aa)
TYRP1Uncharacterized protein. (507 aa)
HSPBAP1HSPB1 associated protein 1. (491 aa)
KDM6BLysine demethylase 6B. (1769 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
EGLN1Uncharacterized protein. (439 aa)
CYP19A1Cytochrome P450 family 19 subfamily A polypeptide 1 transcript variant 1; Belongs to the cytochrome P450 family. (506 aa)
FADS3Fatty acid desaturase 3. (544 aa)
LOC101085921Cytochrome b5 heme-binding domain-containing protein. (484 aa)
LOC109492144Cytochrome b5 heme-binding domain-containing protein. (447 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (498 aa)
KDM7ALysine demethylase 7A. (943 aa)
M3WWR9_FELCADimethylaniline monooxygenase [N-oxide-forming]. (510 aa)
LOC101089804Uncharacterized protein; Belongs to the cytochrome P450 family. (486 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (759 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (468 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (446 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. (529 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
FADS2Fatty acid desaturase 2. (444 aa)
TPH1Tryptophan hydroxylase 1. (527 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
SQLESqualene epoxidase. (574 aa)
FADS6Fatty acid desaturase 6. (342 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
RSBN1Round spermatid basic protein 1. (802 aa)
CCDC160Coiled-coil domain containing 160. (322 aa)
DOHHDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (303 aa)
P4HBProtein disulfide-isomerase. (510 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (242 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (405 aa)
KMOKynurenine 3-monooxygenase. (453 aa)
LOC101091046Uncharacterized protein. (1716 aa)
ENSFCAP00000025991Uncharacterized protein; Belongs to the cytochrome P450 family. (134 aa)
CYP4F8Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family. (479 aa)
ALKBH2AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (260 aa)
ASPHAspartate beta-hydroxylase. (692 aa)
ENSFCAP00000027010Uncharacterized protein. (425 aa)
ENSFCAP00000028450Uncharacterized protein. (475 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (352 aa)
KDM5ALysine demethylase 5A. (1681 aa)
ENSFCAP00000032985Uncharacterized protein. (342 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (495 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
KDM2BLysine demethylase 2B. (1264 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (534 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (424 aa)
ALKBH8AlkB homolog 8, tRNA methyltransferase. (622 aa)
TET2-2Tet methylcytosine dioxygenase 2. (1167 aa)
LOC105259649Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
BBOX1Gamma-butyrobetaine hydroxylase 1. (387 aa)
TET3Tet methylcytosine dioxygenase 3. (1793 aa)
CYP3A131Uncharacterized protein. (503 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
CYP2E2Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
LOC101094994Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
PPHLN1Periphilin 1. (385 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
LOC105260134Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
KDM5CLysine demethylase 5C. (1560 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
LOC101089561Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (727 aa)
LOC109492298FA_desaturase domain-containing protein. (333 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
TMLHETrimethyllysine hydroxylase, epsilon. (421 aa)
KDM2ALysine demethylase 2A. (1224 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (521 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
METTL26Methyltransferase like 26. (204 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
LOC101089396Uncharacterized protein; Belongs to the cytochrome P450 family. (431 aa)
LOC101097790Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (544 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CYP2D6Uncharacterized protein; Belongs to the cytochrome P450 family. (541 aa)
LOC101084948DOMON domain-containing protein. (619 aa)
CYP3A132Uncharacterized protein. (508 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (2203 aa)
TET2Tet_JBP domain-containing protein. (241 aa)
RIOX2Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (523 aa)
CMAHRieske domain-containing protein. (649 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (272 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (548 aa)
PHYHD1Uncharacterized protein. (367 aa)
AGMOAlkylglycerol monooxygenase. (632 aa)
CRTAPCartilage associated protein. (467 aa)
AKR1C3Aldo_ket_red domain-containing protein. (419 aa)
MRRFProstaglandin-endoperoxide synthase 1. (633 aa)
ENSFCAP00000056898Uncharacterized protein. (72 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (558 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (414 aa)
ENSFCAP00000059371Uncharacterized protein. (77 aa)
LOC101083281Uncharacterized protein. (480 aa)
KDM1BLysine demethylase 1B. (1025 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (546 aa)
LOC101087695Uncharacterized protein. (476 aa)
CCNDBP1Cyclin D1 binding protein 1. (411 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (593 aa)
JMJD7Jumonji domain containing 7. (412 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (521 aa)
HMOX1Heme oxygenase 1. (404 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (30%) [HD]