STRINGSTRING
ELOVL5 ELOVL5 ETFBKMT ETFBKMT PANK2 PANK2 NCOR1 NCOR1 FMO2 FMO2 TRIB3 TRIB3 LPGAT1 LPGAT1 ELK4 ELK4 MLYCD MLYCD INSIG1 INSIG1 ENSFCAP00000044386 ENSFCAP00000044386 SOX9 SOX9 TYSND1 TYSND1 FMO1 FMO1 ACADVL ACADVL AKT1 AKT1 LONP2 LONP2 PPARA PPARA IL1B IL1B M3W534_FELCA M3W534_FELCA EIF6 EIF6 LOC101086441 LOC101086441 GIP GIP NR1H2 NR1H2 PDK2 PDK2 FMO4 FMO4 BRCA1 BRCA1 ADIPOQ ADIPOQ SCAP SCAP WDTC1 WDTC1 ANXA1 ANXA1 PIBF1 PIBF1 AKT2 AKT2 APOA4 APOA4 INSIG2 INSIG2 SIRT4 SIRT4 ANKRD26 ANKRD26 FABP5 FABP5 ABCB11 ABCB11 NR1H3 NR1H3 PPARG PPARG ERFE ERFE ERLIN2 ERLIN2 PLIN5 PLIN5 PDK4 PDK4 TREX1 TREX1 ABCD2 ABCD2 PDK1 PDK1 PPARD PPARD SIRT1 SIRT1 CAV1 CAV1 PRKAG2 PRKAG2 MFSD2A MFSD2A PLA2G3 PLA2G3 MLXIPL MLXIPL MID1IP1 MID1IP1 ABCD1 ABCD1 AKT3 AKT3 FMO3 FMO3 APPL2 APPL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
PANK2Pantothenate kinase 2. (570 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
ELK4Solute carrier family 45 member 3. (564 aa)
MLYCDMalonyl-CoA decarboxylase. (496 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
SOX9SRY-box transcription factor 9. (511 aa)
TYSND1Trypsin domain containing 1. (648 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (882 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
M3W534_FELCAUncharacterized protein. (56 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
LOC101086441Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
GIPGLUCAGON domain-containing protein. (222 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (565 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
SCAPSREBF chaperone. (1278 aa)
WDTC1WD and tetratricopeptide repeats 1. (700 aa)
ANXA1Annexin. (407 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (696 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (452 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
SIRT4Sirtuin 4. (335 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
FABP5Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (184 aa)
ABCB11ATP binding cassette subfamily B member 11. (1339 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (498 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ERFEErythroferrone. (343 aa)
ERLIN2ER lipid raft associated 2. (337 aa)
PLIN5Perilipin; Belongs to the perilipin family. (460 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
ABCD2ATP binding cassette subfamily D member 2. (739 aa)
PDK1Protein-serine/threonine kinase. (449 aa)
PPARDPeroxisome proliferator activated receptor delta. (464 aa)
SIRT1Sirtuin 1. (745 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (529 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
MLXIPLMLX interacting protein like. (857 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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