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| | EBI3 | Epstein-Barr virus induced 3. (226 aa) |
| | SYK | Spleen associated tyrosine kinase. (636 aa) |
| | STAT6 | Signal transducer and activator of transcription. (844 aa) |
| | CXCL6 | C-X-C motif chemokine. (148 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (680 aa) |
| | ILK | Integrin linked kinase. (451 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | STAT4 | Signal transducer and activator of transcription. (758 aa) |
| | CCR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (639 aa) |
| | CCL14 | C-C motif chemokine. (95 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (586 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (556 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | TXNDC17 | Thioredoxin domain containing 17. (123 aa) |
| | LOC102899271 | Uncharacterized protein. (631 aa) |
| | CXCR3 | C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | EREG | Epiregulin. (169 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (712 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (554 aa) |
| | CD70 | CD70 molecule; Belongs to the tumor necrosis factor family. (190 aa) |
| | CCL24 | C-C motif chemokine ligand 24. (119 aa) |
| | CCR3 | C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | LOC101088440 | Uncharacterized protein. (183 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (895 aa) |
| | NOTCH1 | Notch receptor 1. (2543 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (427 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | LOC101081599 | SCY domain-containing protein. (158 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (394 aa) |
| | TNFSF13B | TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (357 aa) |
| | LYN | Tyrosine-protein kinase. (526 aa) |
| | CCL13 | C-C motif chemokine. (98 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) |
| | LY6G5B | Lymphocyte antigen 6 family member G5B. (216 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (370 aa) |
| | IL17REL | Interleukin 17 receptor E like. (334 aa) |
| | CD44 | CD44 molecule (Indian blood group). (741 aa) |
| | CRLF2 | Cytokine receptor like factor 2. (370 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (390 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | YAP1 | Yes associated protein 1. (498 aa) |
| | CNTF | Ciliary neurotrophic factor. (200 aa) |
| | ENSFCAP00000050587 | SCY domain-containing protein. (157 aa) |
| | STAT1 | Signal transducer and activator of transcription. (885 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (567 aa) |
| | COMMD7 | COMM domain-containing protein. (417 aa) |
| | TRAF1 | TNF receptor-associated factor. (433 aa) |
| | ENSFCAP00000052225 | C-C motif chemokine. (80 aa) |
| | ENSFCAP00000052397 | Uncharacterized protein. (136 aa) |
| | SLC27A1 | Solute carrier family 27 member 1. (796 aa) |
| | THPO | Thrombopoietin. (409 aa) |
| | TNFRSF13C | TNF receptor superfamily member 13C. (364 aa) |
| | CCR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | LIFR | LIF receptor subunit alpha. (1111 aa) |
| | CXCL13 | C-X-C motif chemokine. (120 aa) |
| | CCR9 | C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | ENSFCAP00000054864 | Uncharacterized protein. (51 aa) |
| | ENSFCAP00000055090 | Uncharacterized protein. (94 aa) |
| | ENSFCAP00000055099 | Uncharacterized protein. (115 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | PLP2 | MARVEL domain-containing protein. (161 aa) |
| | IL36G | Interleukin-1. (219 aa) |
| | LOC101094344 | C-X-C motif chemokine. (113 aa) |
| | ENSFCAP00000057420 | Uncharacterized protein. (443 aa) |
| | LOC111558116 | Ig-like domain-containing protein. (478 aa) |
| | XCR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (298 aa) |
| | WBP1L | WW domain binding protein 1 like. (400 aa) |
| | ENSFCAP00000059570 | Uncharacterized protein. (141 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (638 aa) |
| | ENSFCAP00000059874 | IF rod domain-containing protein; Belongs to the intermediate filament family. (136 aa) |
| | LOC101093854 | C-X-C motif chemokine. (96 aa) |
| | TNFRSF4 | TNF receptor superfamily member 4. (350 aa) |
| | CXCL12 | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (390 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (551 aa) |
| | GFRA4 | GDNF family receptor alpha 4. (271 aa) |
| | CCL19 | C-C motif chemokine. (115 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (449 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (693 aa) |
| | IL17RA | Interleukin 17 receptor A. (862 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (592 aa) |
| | ENSFCAP00000062137 | Ig-like domain-containing protein. (460 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (673 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (469 aa) |
| | CIB1 | Calcium and integrin binding 1. (191 aa) |
| | ADIPOR2 | Adiponectin receptor 2. (386 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | IL34 | Interleukin 34. (331 aa) |
| | SH2B2 | SH2B adaptor protein 2. (679 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (562 aa) |
| | CXCR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | ACTN4 | Actinin alpha 4. (933 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (624 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa) |
| | LOC101086846 | Uncharacterized protein. (125 aa) |
| | LOC101094553 | Uncharacterized protein. (546 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | LOC101085650 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | ACKR2 | Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (505 aa) |
| | IL13RA2 | Interleukin 13 receptor subunit alpha 2. (433 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | CCL1 | SCY domain-containing protein. (94 aa) |
| | RABGEF1 | Uncharacterized protein. (491 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | GFRA2 | GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (463 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) |
| | IL7 | Interleukin 7. (158 aa) |
| | IFNA1 | Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | BBS4 | Bardet-Biedl syndrome 4. (525 aa) |
| | IL17A | Interleukin 17A. (155 aa) |
| | ENSFCAP00000033605 | Uncharacterized protein. (147 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa) |
| | LOC100302540 | C-C motif chemokine. (93 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | LOC101100838 | Uncharacterized protein. (124 aa) |
| | OSM | Oncostatin M. (238 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | LOC101100621 | Fibronectin type-III domain-containing protein. (324 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9. (299 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | CCL22 | C-C motif chemokine. (93 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (539 aa) |
| | GHR | Growth hormone receptor. (688 aa) |
| | CXCL11 | C-X-C motif chemokine. (100 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | IFNA13 | Uncharacterized protein. (193 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (430 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | RPS6KA4 | Ribosomal protein S6 kinase. (771 aa) |
| | IL5RA | Interleukin 5 receptor subunit alpha. (420 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (969 aa) |
| | IRF5 | Interferon regulatory factor 5. (504 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (798 aa) |
| | CD300LF | CD300 molecule like family member f. (384 aa) |
| | GFRA3 | GDNF family receptor alpha 3. (395 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (294 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (861 aa) |
| | JAK1 | Tyrosine-protein kinase. (1157 aa) |
| | STAT5B | Signal transducer and activator of transcription. (786 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | LOC101081091 | C-C motif chemokine. (93 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (390 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | IFNLR1 | Interferon lambda receptor 1. (611 aa) |
| | ACKR1 | Atypical chemokine receptor 1 (Duffy blood group). (339 aa) |
| | IL4R | Interleukin 4 receptor. (818 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor. (440 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | LOC100302541 | C-C motif chemokine. (102 aa) |
| | CCL7 | C-C motif chemokine. (99 aa) |
| | TFF2 | Trefoil factor 2. (176 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | CCL26 | C-C motif chemokine. (94 aa) |
| | IL17RC | Interleukin 17 receptor C. (651 aa) |
| | IL31RA | Interleukin 31 receptor A. (661 aa) |
| | TNFSF18 | TNF superfamily member 18. (178 aa) |
| | RHEX | Regulator of hemoglobinization and erythroid cell expansion. (169 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | TNFRSF17 | TNF receptor superfamily member 17. (176 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (388 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | TOLLIP | Toll interacting protein. (306 aa) |
| | LOC101094096 | C-X-C motif chemokine. (104 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | CCR10 | C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa) |
| | ENSFCAP00000046520 | IF rod domain-containing protein; Belongs to the intermediate filament family. (148 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (203 aa) |
| | IL17RE | Interleukin 17 receptor E. (594 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (652 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | CCR8 | C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) |
| | CCR4 | C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | IL9R | Interleukin 9 receptor. (599 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa) |
| | CCL21 | C-C motif chemokine ligand 21. (134 aa) |
| | SH2B3 | SH2B adaptor protein 3. (578 aa) |
| | CCL20 | C-C motif chemokine. (97 aa) |
| | IL17RD | Interleukin 17 receptor D. (736 aa) |
| | LOC102899310 | Ig-like domain-containing protein. (320 aa) |
| | CSF1R | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa) |
| | ACKR4 | Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa) |
| | CD4 | CD4 molecule. (487 aa) |
| | NUMBL | NUMB like endocytic adaptor protein. (678 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | CCL17 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa) |
| | EPOR | Erythropoietin receptor; Receptor for erythropoietin. (508 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (698 aa) |
| | IL17RB | Interleukin 17 receptor B. (494 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | IL22RA1 | Interleukin 22 receptor subunit alpha 1. (581 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | GFRAL | GDNF family receptor alpha like. (365 aa) |
| | CXCR6 | C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa) |
| | CCR1 | Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | DOK1 | Docking protein 1. (493 aa) |
| | JAK3 | Tyrosine-protein kinase. (1232 aa) |
| | DUOX2 | Dual oxidase 2. (1547 aa) |
| | DUOX1 | Dual oxidase 1. (1551 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | OSMR | Oncostatin M receptor. (961 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | NMI | N-myc and STAT interactor. (309 aa) |
| | IL17F | Interleukin 17F. (157 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (720 aa) |
| | IL15RA | Interleukin 15 receptor subunit alpha. (268 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | IL7R | Interleukin 7 receptor. (457 aa) |
| | TYK2 | Tyrosine-protein kinase. (1181 aa) |
| | CRLF1 | Cytokine receptor like factor 1. (421 aa) |
| | IL21R | Interleukin 21 receptor. (538 aa) |
| | CCL16 | C-C motif chemokine. (107 aa) |
| | M3WCQ5_FELCA | Uncharacterized protein. (151 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | IL6ST | Interleukin 6 signal transducer. (918 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (618 aa) |
| | STK39 | Serine/threonine kinase 39. (543 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (296 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | STAT2 | Signal transducer and activator of transcription. (855 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (418 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (572 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (406 aa) |
| | F3 | Coagulation factor III, tissue factor. (379 aa) |
| | CSF3R | Colony stimulating factor 3 receptor. (839 aa) |
| | IRF1 | Interferon regulatory factor. (322 aa) |
| | GPR75 | G protein-coupled receptor 75. (577 aa) |
| | CCL8 | C-C motif chemokine. (99 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | EDN2 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa) |
