STRINGSTRING
PAF1 PAF1 ZIC3 ZIC3 DIS3L2 DIS3L2 KLF10 KLF10 TRIM8 TRIM8 MED15 MED15 JAG1 JAG1 MED27 MED27 DLL1 DLL1 CTR9 CTR9 WNT9B WNT9B PHF19 PHF19 BCL9L BCL9L NODAL NODAL PRDM14 PRDM14 NANOG NANOG STAT3 STAT3 NR2E1 NR2E1 IGF2BP1 IGF2BP1 FANCC FANCC NIPBL NIPBL VPS72 VPS72 SETD6 SETD6 SRRT SRRT METTL14 METTL14 MED14 MED14 LDB2 LDB2 PADI1 PADI1 SMC3 SMC3 FANCD2 FANCD2 RTF1 RTF1 BRAF BRAF PIWIL2 PIWIL2 SMC1A SMC1A CUL4A CUL4A MTF2 MTF2 MED7 MED7 GNL3 GNL3 RIF1 RIF1 HOOK3 HOOK3 ZHX2 ZHX2 PROX1 PROX1 MMP24 MMP24 M3WTU8_FELCA M3WTU8_FELCA LOC101084379 LOC101084379 LEO1 LEO1 NOTCH1 NOTCH1 MED30 MED30 HESX1 HESX1 FOXO3 FOXO3 ASPM ASPM NANOS2 NANOS2 LIG4 LIG4 BMPR1A BMPR1A LRP5 LRP5 ENSFCAP00000026456 ENSFCAP00000026456 SMC5 SMC5 FZD7 FZD7 RAF1 RAF1 FGF10 FGF10 FGF4 FGF4 DDX6 DDX6 LIF LIF SFRP1 SFRP1 SALL4 SALL4 PADI4 PADI4 MED21 MED21 PELO PELO ENSFCAP00000037965 ENSFCAP00000037965 SS18 SS18 LSM1 LSM1 MED12 MED12 HES5 HES5 MED17 MED17 REST REST LDB1 LDB1 FAXC FAXC EIF4E EIF4E ZFP36L2 ZFP36L2 SOX9 SOX9 NOG NOG TBX3 TBX3 PCM1 PCM1 YAP1 YAP1 EIF4ENIF1 EIF4ENIF1 HES1 HES1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa)
ZIC3Zic family member 3. (553 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (1028 aa)
KLF10Kruppel like factor 10. (493 aa)
TRIM8Tripartite motif containing 8. (551 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
MED27Mediator complex subunit 27. (427 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
PHF19PHD finger protein 19. (548 aa)
BCL9LBCL9 like. (1393 aa)
NODALNodal growth differentiation factor. (348 aa)
PRDM14PR/SET domain 14. (572 aa)
NANOGNanog homeobox. (311 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
FANCCFA complementation group C. (597 aa)
NIPBLNipped-B protein. (2805 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (454 aa)
SRRTSerrate, RNA effector molecule. (876 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
LDB2LIM domain binding 2. (373 aa)
PADI1Peptidyl arginine deiminase 1. (663 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
FANCD2FA complementation group D2. (1450 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
CUL4ACullin 4A; Belongs to the cullin family. (761 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
GNL3G protein nucleolar 3. (549 aa)
RIF1Replication timing regulatory factor 1. (2479 aa)
HOOK3Hook microtubule tethering protein 3. (772 aa)
ZHX2Zinc fingers and homeoboxes 2. (838 aa)
PROX1Prospero homeobox 1. (737 aa)
MMP24Matrix metallopeptidase 24. (630 aa)
M3WTU8_FELCAUncharacterized protein. (84 aa)
LOC101084379Homeobox domain-containing protein. (290 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (664 aa)
NOTCH1Notch receptor 1. (2543 aa)
MED30Mediator complex subunit 30. (178 aa)
HESX1HESX homeobox 1. (207 aa)
FOXO3Forkhead box O3. (672 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
LIG4DNA ligase. (911 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa)
ENSFCAP00000026456Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (128 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SALL4Spalt like transcription factor 4. (1058 aa)
PADI4Peptidyl arginine deiminase 4. (664 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ENSFCAP00000037965Homeobox domain-containing protein. (281 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (418 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
MED12Mediator complex subunit 12. (2278 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (692 aa)
RESTRE1 silencing transcription factor. (1045 aa)
LDB1LIM domain binding 1. (411 aa)
FAXCFailed axon connections homolog, metaxin like GST domain containing. (436 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
ZFP36L2ZFP36 ring finger protein like 2. (705 aa)
SOX9SRY-box transcription factor 9. (511 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX3T-box transcription factor 3. (745 aa)
PCM1Pericentriolar material 1. (2184 aa)
YAP1Yes associated protein 1. (498 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (1026 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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