(30 nodes) Chemokine binding network (Felis catus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (592 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa)
	XCR1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (298 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	PLP2	MARVEL domain-containing protein. (161 aa)
	CCR5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	ENSFCAP00000052397	Uncharacterized protein. (136 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	ZFP36	ZFP36 ring finger protein. (513 aa)
	CCR10	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	ACKR1	Atypical chemokine receptor 1 (Duffy blood group). (339 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
	ACKR2	Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (505 aa)
	LOC101085650	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	CXCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
	CCR3	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	CCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
	PDPN	Podoplanin. (163 aa)
	CCR1	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	CXCR6	C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	ACKR4	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	CCR4	C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	CCR8	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	ACKR3	ENSFCAP00000040185	ENSFCAP00000011652	Atypical chemokine receptor 1 (Duffy blood group).	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.592
ACKR1	ACKR4	ENSFCAP00000040185	ENSFCAP00000003575	Atypical chemokine receptor 1 (Duffy blood group).	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.752
ACKR1	CCR2	ENSFCAP00000040185	ENSFCAP00000015566	Atypical chemokine receptor 1 (Duffy blood group).	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.486
ACKR1	CCR5	ENSFCAP00000040185	ENSFCAP00000054547	Atypical chemokine receptor 1 (Duffy blood group).	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.459
ACKR1	CXCR4	ENSFCAP00000040185	ENSFCAP00000060751	Atypical chemokine receptor 1 (Duffy blood group).	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.413
ACKR3	ACKR1	ENSFCAP00000011652	ENSFCAP00000040185	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 1 (Duffy blood group).	0.592
ACKR3	CCR10	ENSFCAP00000011652	ENSFCAP00000046219	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.525
ACKR3	CCR2	ENSFCAP00000011652	ENSFCAP00000015566	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.546
ACKR3	CCR6	ENSFCAP00000011652	ENSFCAP00000061973	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.470
ACKR3	CCR7	ENSFCAP00000011652	ENSFCAP00000038973	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.545
ACKR3	CCR8	ENSFCAP00000011652	ENSFCAP00000002515	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family.	0.409
ACKR3	CXCR3	ENSFCAP00000011652	ENSFCAP00000017739	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.635
ACKR3	CXCR4	ENSFCAP00000011652	ENSFCAP00000060751	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.993
ACKR3	CXCR5	ENSFCAP00000011652	ENSFCAP00000043494	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.558
ACKR3	CXCR6	ENSFCAP00000011652	ENSFCAP00000006338	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.524
ACKR4	ACKR1	ENSFCAP00000003575	ENSFCAP00000040185	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 1 (Duffy blood group).	0.752
ACKR4	CCR7	ENSFCAP00000003575	ENSFCAP00000038973	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.919
CCR1	CCR10	ENSFCAP00000006339	ENSFCAP00000046219	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.711
CCR1	CCR2	ENSFCAP00000006339	ENSFCAP00000015566	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.804
CCR1	CCR3	ENSFCAP00000006339	ENSFCAP00000019617	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.967