STRINGSTRING
FSHR FSHR SGPL1 SGPL1 STAT5B STAT5B NRIP1 NRIP1 PDGFRA PDGFRA LHCGR LHCGR SLIT3 SLIT3 ADAMTS1 ADAMTS1 ESR1 ESR1 AFP AFP FOXO3 FOXO3 GPR149 GPR149 TNFAIP6 TNFAIP6 SIRT1 SIRT1 GAS2 GAS2 FZD4 FZD4 BMPR1B BMPR1B NR5A2 NR5A2 SLIT2 SLIT2 LOC101094201 LOC101094201 INHBA INHBA NR5A1 NR5A1 PTX3 PTX3 STAT5A STAT5A SCAPER SCAPER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (671 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
AFPAlpha fetoprotein. (609 aa)
FOXO3Forkhead box O3. (672 aa)
GPR149G protein-coupled receptor 149. (747 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
SIRT1Sirtuin 1. (745 aa)
GAS2Growth arrest specific 2. (314 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
LOC101094201SCHIP-1 domain-containing protein. (489 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
PTX3Pentraxin 3. (381 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1401 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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