STRINGSTRING
PLXND1 PLXND1 AREG AREG ELF3 ELF3 CHCHD6 CHCHD6 SCRIB SCRIB HOXB13 HOXB13 CSMD2 CSMD2 PML PML TNC TNC TGFB1 TGFB1 BSX BSX PAX6 PAX6 SERPINB5 SERPINB5 LAMA1 LAMA1 TBX2 TBX2 NOTCH2 NOTCH2 EPHA2 EPHA2 DDR1 DDR1 CSF1 CSF1 GLI3 GLI3 KDM5B KDM5B MSN MSN TGFB3 TGFB3 STAT6 STAT6 LRRC1 LRRC1 PROX1 PROX1 SEMA3C SEMA3C FGF7 FGF7 RXFP1 RXFP1 NOTCH1 NOTCH1 ESR1 ESR1 FOXA1 FOXA1 VDR VDR PHB2 PHB2 TWSG1 TWSG1 IL6 IL6 LRP5 LRP5 HOXD13 HOXD13 TP63 TP63 CSMD1 CSMD1 CAV1 CAV1 MST1 MST1 TGFB2 TGFB2 FGF10 FGF10 SELENOH SELENOH SLC9A3R1 SLC9A3R1 SFRP1 SFRP1 NRG3 NRG3 ESRP2 ESRP2 SOSTDC1 SOSTDC1 FRS2 FRS2 TGFA TGFA BTRC BTRC SRC SRC CUL3 CUL3 EDA EDA MED1 MED1 NKX2-3 NKX2-3 PLAG1 PLAG1 PTCH1 PTCH1 SOX9 SOX9 FEM1B FEM1B NOG NOG FGL1 FGL1 TBX3 TBX3 EDAR EDAR DAG1 DAG1 CEBPB CEBPB TNF TNF RARG RARG BMP4 BMP4 GDF7 GDF7 HOXA13 HOXA13 NKX3-1 NKX3-1 POLB POLB NFIB NFIB TGM2 TGM2 NTN1 NTN1 ETV4 ETV4 MKI67 MKI67
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLXND1Plexin D1. (1927 aa)
AREGAmphiregulin. (323 aa)
ELF3E74 like ETS transcription factor 3. (370 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (2112 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
HOXB13Homeobox B13. (285 aa)
CSMD2CUB and Sushi multiple domains 2. (3632 aa)
PMLPromyelocytic leukemia. (876 aa)
TNCTenascin C. (2200 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BSXBrain specific homeobox. (232 aa)
PAX6Paired box 6. (437 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (379 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
TBX2T-box transcription factor 2. (713 aa)
NOTCH2Notch receptor 2. (2493 aa)
EPHA2EPH receptor A2. (936 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (921 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
GLI3GLI family zinc finger 3. (1578 aa)
KDM5BLysine demethylase 5B. (1544 aa)
MSNMoesin. (577 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
PROX1Prospero homeobox 1. (737 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (749 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
NOTCH1Notch receptor 1. (2543 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
FOXA1Forkhead box A1. (536 aa)
VDRVitamin D receptor. (441 aa)
PHB2Prohibitin. (299 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa)
HOXD13Homeobox D13. (341 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CSMD1CUB and Sushi multiple domains 1. (3501 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
SELENOHSelenoprotein H. (121 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NRG3Neuregulin 3. (720 aa)
ESRP2Epithelial splicing regulatory protein 2. (726 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
FRS2Fibroblast growth factor receptor substrate 2. (543 aa)
TGFATransforming growth factor alpha. (192 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
SRCTyrosine-protein kinase. (678 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (388 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
NKX2-3NK2 homeobox 3. (368 aa)
PLAG1PLAG1 zinc finger. (499 aa)
PTCH1Patched 1. (1451 aa)
SOX9SRY-box transcription factor 9. (511 aa)
FEM1BFem-1 homolog B. (627 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGL1Fibrinogen like 1. (378 aa)
TBX3T-box transcription factor 3. (745 aa)
EDAREctodysplasin A receptor. (447 aa)
DAG1Peptidase S72 domain-containing protein. (892 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
RARGRetinoic acid receptor gamma. (459 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GDF7Growth differentiation factor 7. (455 aa)
HOXA13Homeobox A13. (389 aa)
NKX3-1NK3 homeobox 1. (231 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (428 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
TGM2Transglutaminase 2. (733 aa)
NTN1Netrin 1. (715 aa)
ETV4ETS variant 4. (488 aa)
MKI67FHA domain-containing protein. (2865 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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