STRINGSTRING
PTK2B PTK2B TWF2 TWF2 ABI1 ABI1 TESK1 TESK1 PALLD PALLD APC2 APC2 ABLIM3 ABLIM3 LOC102901344 LOC102901344 ENSFCAP00000041826 ENSFCAP00000041826 TSC1 TSC1 MYLK MYLK NME2 NME2 DPYSL3 DPYSL3 FAM89B FAM89B ENSFCAP00000045292 ENSFCAP00000045292 PKN2 PKN2 SHTN1 SHTN1 CDK5 CDK5 CAPRIN1 CAPRIN1 SLC39A6 SLC39A6 VAMP7 VAMP7 LOC101100956 LOC101100956 LOC101096707 LOC101096707 LGALS1 LGALS1 ENSFCAP00000047404 ENSFCAP00000047404 BCAR1 BCAR1 CD44 CD44 DAG1 DAG1 CCDC88A CCDC88A RAB13 RAB13 SYNE2 SYNE2 ITGAV ITGAV ENSFCAP00000051431 ENSFCAP00000051431 DGKZ DGKZ TTN TTN PHACTR4 PHACTR4 ACTR3B ACTR3B RAC3 RAC3 STX3 STX3 SPATA13 SPATA13 ACTN1 ACTN1 GSN GSN CARMIL1 CARMIL1 SPEF1 SPEF1 PODXL PODXL DBNL DBNL IQGAP2 IQGAP2 KITLG KITLG AIF1 AIF1 RAC1 RAC1 HPX HPX ACTA1 ACTA1 ENSFCAP00000058156 ENSFCAP00000058156 ENSFCAP00000058078 ENSFCAP00000058078 CDC42BPB CDC42BPB ENSFCAP00000057420 ENSFCAP00000057420 KCNA2 KCNA2 PARVB PARVB RAC2 RAC2 CARMIL3 CARMIL3 ENSFCAP00000055751 ENSFCAP00000055751 ENSFCAP00000055519 ENSFCAP00000055519 PLCG1 PLCG1 LOC109492241 LOC109492241 PPP1R9B PPP1R9B CIB1 CIB1 P4HB P4HB CDC42-2 CDC42-2 FAT1 FAT1 ARHGEF7 ARHGEF7 CORO1C CORO1C PKD2 PKD2 WASL WASL ENSFCAP00000028191 ENSFCAP00000028191 EVL EVL ITGB1BP1 ITGB1BP1 ITGB1 ITGB1 ENSFCAP00000032522 ENSFCAP00000032522 MYH10 MYH10 ITGB3 ITGB3 STMN2 STMN2 LIMK1 LIMK1 CORO6 CORO6 ALS2 ALS2 FLOT2 FLOT2 CARMIL2 CARMIL2 MYO10 MYO10 UNC5C UNC5C ROCK1 ROCK1 PIK3CA PIK3CA ABITRAM ABITRAM DPP4 DPP4 RAPGEF3 RAPGEF3 CORO1A CORO1A HAX1 HAX1 SCYL3 SCYL3 APC APC PABPC1 PABPC1 PLXND1 PLXND1 FGD1 FGD1 VILL VILL VIL1 VIL1 IGF2BP1 IGF2BP1 CAPG CAPG CORO1B CORO1B ARPC3 ARPC3 PAK1 PAK1 ARHGEF6 ARHGEF6 SNX1 SNX1 NF2 NF2 CTTN CTTN CDC42 CDC42 INPPL1 INPPL1 FSCN3 FSCN3 PIP5K1A PIP5K1A KCNA1 KCNA1 STX2 STX2 KPTN KPTN PLCE1 PLCE1 AJUBA AJUBA ACTA2 ACTA2 VASP VASP PDPN PDPN M3W868_FELCA M3W868_FELCA FLOT1 FLOT1 WASF2 WASF2 GDPD2 GDPD2 CIB3 CIB3 FSCN1 FSCN1 MYO1G MYO1G WASF3 WASF3 EPHA2 EPHA2 CLRN1 CLRN1 PARVA PARVA BRK1 BRK1 ACTG2 ACTG2 AMOT AMOT ABI2 ABI2 CYFIP1 CYFIP1 CFL1 CFL1 PLEKHH2 PLEKHH2 ACTR3 ACTR3 PDLIM4 PDLIM4 ACTC1 ACTC1 ILK ILK ARPC5 ARPC5 ABI3 ABI3 SNX2 SNX2 SH3BP1 SH3BP1 WASF1 WASF1 SH3RF1 SH3RF1 RHOA RHOA ARHGAP31 ARHGAP31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
ABI1Abl interactor 1. (508 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
PALLDPalladin, cytoskeletal associated protein. (1404 aa)
APC2APC regulator of WNT signaling pathway 2. (2289 aa)
ABLIM3Actin binding LIM protein family member 3. (683 aa)
LOC102901344Uncharacterized protein. (226 aa)
ENSFCAP00000041826Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
TSC1TSC complex subunit 1. (1110 aa)
MYLKUncharacterized protein. (1920 aa)
NME2Nucleoside diphosphate kinase. (152 aa)
DPYSL3Dihydropyrimidinase like 3. (687 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
ENSFCAP00000045292CH_2 domain-containing protein. (564 aa)
PKN2Protein kinase N2. (983 aa)
SHTN1Shootin 1. (631 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CAPRIN1Cell cycle associated protein 1. (709 aa)
SLC39A6Solute carrier family 39 member 6. (735 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
LOC101100956Uncharacterized protein. (129 aa)
LOC101096707Death domain-containing protein. (220 aa)
LGALS1Galectin. (367 aa)
ENSFCAP00000047404Uncharacterized protein. (56 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (889 aa)
CD44CD44 molecule (Indian blood group). (741 aa)
DAG1Peptidase S72 domain-containing protein. (892 aa)
CCDC88ACoiled-coil domain containing 88A. (1874 aa)
RAB13Uncharacterized protein. (203 aa)
SYNE2KASH domain-containing protein. (3641 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSFCAP00000051431Uncharacterized protein. (289 aa)
DGKZDiacylglycerol kinase. (1119 aa)
TTNTitin. (27108 aa)
PHACTR4Phosphatase and actin regulator. (752 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (522 aa)
RAC3Rac family small GTPase 3. (205 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (375 aa)
SPATA13Uncharacterized protein. (1320 aa)
ACTN1Actinin alpha 1. (927 aa)
GSNGelsolin. (815 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1420 aa)
SPEF1Sperm flagellar 1. (343 aa)
PODXLPodocalyxin like. (594 aa)
DBNLDrebrin like. (522 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
KITLGSoluble KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). (274 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
RAC1Rac family small GTPase 1. (221 aa)
HPXAmyloid beta precursor protein binding family B member 1. (1091 aa)
ACTA1Actin alpha 1, skeletal muscle. (457 aa)
ENSFCAP00000058156Uncharacterized protein. (552 aa)
ENSFCAP00000058078Uncharacterized protein. (545 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1712 aa)
ENSFCAP00000057420Uncharacterized protein. (443 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
PARVBParvin beta. (413 aa)
RAC2Rac family small GTPase 2. (234 aa)
CARMIL3Capping protein regulator and myosin 1 linker 3. (1408 aa)
ENSFCAP00000055751Uncharacterized protein. (272 aa)
ENSFCAP00000055519Uncharacterized protein. (556 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
LOC109492241Uncharacterized protein. (424 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (889 aa)
CIB1Calcium and integrin binding 1. (191 aa)
P4HBProtein disulfide-isomerase. (510 aa)
CDC42-2Uncharacterized protein. (191 aa)
FAT1FAT atypical cadherin 1. (4586 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (921 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ENSFCAP00000028191Uncharacterized protein. (552 aa)
EVLEnah/Vasp-like. (461 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (213 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
ENSFCAP00000032522Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (132 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
STMN2Stathmin 2. (202 aa)
LIMK1LIM domain kinase 1. (763 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1650 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (553 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1367 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2047 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ABITRAMActin binding transcription modulator. (181 aa)
DPP4Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (765 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (655 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (281 aa)
SCYL3SCY1 like pseudokinase 3. (688 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
PLXND1Plexin D1. (1927 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (960 aa)
VILLVillin like. (855 aa)
VIL1Villin 1. (827 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
CAPGCapping actin protein, gelsolin like. (388 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (775 aa)
SNX1Sorting nexin 1. (521 aa)
NF2Neurofibromin 2. (596 aa)
CTTNCortactin. (538 aa)
CDC42Uncharacterized protein. (191 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
FSCN3Fascin. (497 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (550 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
KPTNKaptin, actin binding protein. (507 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
AJUBAAjuba LIM protein. (548 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
PDPNPodoplanin. (163 aa)
M3W868_FELCATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
WASF2WASP family member 2. (498 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (569 aa)
CIB3Calcium and integrin binding family member 3. (187 aa)
FSCN1Fascin actin-bundling protein 1. (518 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1017 aa)
WASF3WASP family member 3. (502 aa)
EPHA2EPH receptor A2. (936 aa)
CLRN1Uncharacterized protein. (232 aa)
PARVAParvin alpha. (372 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
AMOTAngiomotin. (1075 aa)
ABI2Abl interactor 2. (542 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1492 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
PDLIM4PDZ and LIM domain 4. (330 aa)
ACTC1Actin alpha cardiac muscle 1. (616 aa)
ILKIntegrin linked kinase. (451 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ABI3ABI family member 3. (365 aa)
SNX2Sorting nexin 2. (523 aa)
SH3BP1Uncharacterized protein. (734 aa)
WASF1WASP family member 1. (570 aa)
SH3RF1SH3 domain containing ring finger 1. (889 aa)
RHOARas homolog family member A. (193 aa)
ARHGAP31Rho GTPase activating protein 31. (1450 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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