STRINGSTRING
PPP1R9B PPP1R9B CGRRF1 CGRRF1 DNAJB2 DNAJB2 CCDC85B CCDC85B SEMA4C SEMA4C NDUFS3 NDUFS3 MSX1 MSX1 SEMA5B SEMA5B DCBLD2 DCBLD2 LOC101092676 LOC101092676 TP53 TP53 INHBA INHBA CIRBP CIRBP PTPRS PTPRS CDKN1B CDKN1B CDKN1C CDKN1C SEMA6C SEMA6C C10orf90 C10orf90 WT1 WT1 SPHK2 SPHK2 FLCN FLCN PHB PHB SEMA5A SEMA5A SOX17 SOX17 SLIT2 SLIT2 SFRP2 SFRP2 ACVRL1 ACVRL1 WNT3A WNT3A OSGIN2 OSGIN2 SFRP1 SFRP1 SEMA6D SEMA6D SMAD3 SMAD3 ST7L ST7L TGFB2 TGFB2 SMARCA4 SMARCA4 DRAXIN DRAXIN NME6 NME6 SERTAD3 SERTAD3 NAIF1 NAIF1 SMARCA2 SMARCA2 SERPINE2 SERPINE2 RYK RYK RACK1 RACK1 CDHR2 CDHR2 PML PML SEMA4D SEMA4D PTPRJ PTPRJ TGFB1 TGFB1 CCAR2 CCAR2 BCL6 BCL6 SEMA3F SEMA3F HYAL2 HYAL2 SEMA7A SEMA7A HNF4A HNF4A DCSTAMP DCSTAMP FBP1 FBP1 ULK1 ULK1 SLIT3 SLIT3 WNT3 WNT3 GDF9 GDF9 CYP27C1 CYP27C1 FRZB FRZB STK11 STK11 HRG HRG BMPR2 BMPR2 NDUFA13 NDUFA13 TNR TNR FSTL4 FSTL4 CYP27B1 CYP27B1 DCUN1D3 DCUN1D3 SEMA4G SEMA4G SEMA3G SEMA3G EAF2 EAF2 M3WS82_FELCA M3WS82_FELCA SEMA3E SEMA3E CDKN2AIP CDKN2AIP IP6K2 IP6K2 SEMA3C SEMA3C CRLF3 CRLF3 PI16 PI16 DDX3X DDX3X CDKN2D CDKN2D WNT11 WNT11 CDKN1A CDKN1A RBBP7 RBBP7 CDK5 CDK5 OSTN OSTN ACVR1B ACVR1B GSK3A GSK3A GJA1 GJA1 DIP2B DIP2B TSPYL2 TSPYL2 RTN4 RTN4 SERTAD1 SERTAD1 SEMA3D SEMA3D FHL1 FHL1 SEMA3A SEMA3A SEMA4B SEMA4B RB1 RB1 CDKL3 CDKL3 SEMA6A SEMA6A BMP10 BMP10 SPART SPART SIRT1 SIRT1 ENSFCAP00000028212 ENSFCAP00000028212 RTN4R RTN4R CDKN2C CDKN2C MYL10 MYL10 ST7 ST7 ENSFCAP00000030321 ENSFCAP00000030321 SMAD4 SMAD4 PLXNA3 PLXNA3 SEMA6B SEMA6B SERTAD2 SERTAD2 GNG4 GNG4 ENPP1 ENPP1 SEMA3B SEMA3B TP53TG5 TP53TG5 MUL1 MUL1 MINAR1 MINAR1 NTN1 NTN1 PSRC1 PSRC1 SH3BP4 SH3BP4 GAS1 GAS1 MYL2 MYL2 RERG RERG CCN3 CCN3 SESN2 SESN2 IFRD2 IFRD2 ADAM15 ADAM15 SEMA4A SEMA4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (889 aa)
CGRRF1Cell growth regulator with ring finger domain 1. (333 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (325 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (265 aa)
MSX1Msh homeobox 1. (303 aa)
SEMA5BSemaphorin 5B. (1100 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (791 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
CIRBPCold inducible RNA binding protein. (172 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1947 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (1023 aa)
C10orf90Chromosome 10 open reading frame 90. (655 aa)
WT1WT1 transcription factor. (523 aa)
SPHK2DAGKc domain-containing protein. (660 aa)
FLCNUncharacterized protein. (579 aa)
PHBProhibitin. (272 aa)
SEMA5ASemaphorin 5A. (1116 aa)
SOX17SRY-box transcription factor 17. (406 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (562 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1069 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
ST7LSuppression of tumorigenicity 7 like. (666 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (377 aa)
NME6Nucleoside diphosphate kinase. (193 aa)
SERTAD3SERTA domain containing 3. (209 aa)
NAIF1Nuclear apoptosis inducing factor 1. (327 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1574 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (484 aa)
RYKReceptor like tyrosine kinase. (609 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (424 aa)
CDHR2Cadherin related family member 2. (1338 aa)
PMLPromyelocytic leukemia. (876 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1213 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCAR2Cell cycle and apoptosis regulator 2. (918 aa)
BCL6BCL6 transcription repressor. (745 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
HYAL2Hyaluronidase. (780 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (769 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GDF9Growth differentiation factor 9. (452 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
FRZBFrizzled related protein. (324 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
HRGHistidine rich glycoprotein. (536 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
TNRTenascin R. (1358 aa)
FSTL4Follistatin like 4. (842 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
DCUN1D3Defective in cullin neddylation 1 domain containing 3. (304 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (840 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (768 aa)
EAF2ELL associated factor 2. (264 aa)
M3WS82_FELCAGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (292 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
CDKN2AIPCDKN2A interacting protein. (583 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (749 aa)
CRLF3Cytokine receptor like factor 3. (498 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (458 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
OSTNOsteocrin. (132 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
DIP2BDisco interacting protein 2 homolog B. (1576 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (756 aa)
RTN4Reticulon. (1190 aa)
SERTAD1SERTA domain containing 1. (242 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (798 aa)
FHL1Four and a half LIM domains 1. (366 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (773 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
RB1RB transcriptional corepressor 1. (930 aa)
CDKL3Cyclin dependent kinase like 3. (581 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
SPARTSpartin. (672 aa)
SIRT1Sirtuin 1. (745 aa)
ENSFCAP00000028212Uncharacterized protein. (83 aa)
RTN4RReticulon 4 receptor. (474 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
MYL10Myosin light chain 10. (167 aa)
ST7Suppressor of tumorigenicity 7 protein. (585 aa)
ENSFCAP00000030321Uncharacterized protein. (79 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PLXNA3Plexin A3. (1872 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (1296 aa)
SERTAD2SERTA domain containing 2. (366 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (777 aa)
TP53TG5TP53 target 5. (311 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (1186 aa)
NTN1Netrin 1. (715 aa)
PSRC1Proline and serine rich coiled-coil 1. (407 aa)
SH3BP4SH3 domain binding protein 4. (1056 aa)
GAS1Growth arrest specific 1. (369 aa)
MYL2Myosin light chain 2. (174 aa)
RERGRAS like estrogen regulated growth inhibitor. (246 aa)
CCN3Cellular communication network factor 3. (394 aa)
SESN2Sestrin 2. (516 aa)
IFRD2Interferon related developmental regulator 2. (495 aa)
ADAM15ADAM metallopeptidase domain 15. (869 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (806 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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