35 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	XRCC6	X-ray repair cross complementing 6. (608 aa)
	UBE3D	Ubiquitin protein ligase E3D. (436 aa)
	ENSFCAP00000060774	Protein kinase domain-containing protein. (78 aa)
	ZYG11B	Zyg-11 family member B, cell cycle regulator. (750 aa)
	KLHDC9	Kelch domain containing 9. (450 aa)
	INCA1	Inhibitor of CDK, cyclin A1 interacting protein 1. (256 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
	CIZ1	CDKN1A interacting zinc finger protein 1. (851 aa)
	PTCH1	Patched 1. (1451 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
	CDKN1C	Cyclin dependent kinase inhibitor 1C. (264 aa)
	USP2	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (857 aa)
	CDK13	Cyclin dependent kinase 13. (1514 aa)
	MDFIC	MyoD family inhibitor domain containing. (244 aa)
	FBXO31	F-box protein 31. (643 aa)
	HAUS3	HAUS augmin like complex subunit 3. (603 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	ENSFCAP00000030321	Uncharacterized protein. (79 aa)
	RBM4	RNA binding motif protein 4. (365 aa)
	ENSFCAP00000028212	Uncharacterized protein. (83 aa)
	GPS2	Uncharacterized protein. (327 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
	CDK14	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (428 aa)
	M3WPU0_FELCA	Uncharacterized protein. (162 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	CDK12	Cyclin dependent kinase 12. (1458 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (504 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1025 aa)
	RACK1	WD_REPEATS_REGION domain-containing protein. (424 aa)
	ZYG11A	Zyg-11 family member A, cell cycle regulator. (756 aa)
	FBXW7	F-box and WD repeat domain containing 7. (749 aa)
	CDK15	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily. (435 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK1	CDK2	ENSFCAP00000013888	ENSFCAP00000031371	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.821
CDK1	CDKN1A	ENSFCAP00000013888	ENSFCAP00000020450	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.813
CDK1	CDKN1B	ENSFCAP00000013888	ENSFCAP00000044526	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.624
CDK1	CDKN1C	ENSFCAP00000013888	ENSFCAP00000043917	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1C.	0.624
CDK1	CUL3	ENSFCAP00000013888	ENSFCAP00000043479	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cullin 3; Belongs to the cullin family.	0.421
CDK1	HAUS3	ENSFCAP00000013888	ENSFCAP00000036054	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	HAUS augmin like complex subunit 3.	0.405
CDK12	CDK13	ENSFCAP00000009183	ENSFCAP00000043114	Cyclin dependent kinase 12.	Cyclin dependent kinase 13.	0.572
CDK13	CDK12	ENSFCAP00000043114	ENSFCAP00000009183	Cyclin dependent kinase 13.	Cyclin dependent kinase 12.	0.572
CDK14	CDKN1A	ENSFCAP00000017585	ENSFCAP00000020450	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.524
CDK14	CDKN1B	ENSFCAP00000017585	ENSFCAP00000044526	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.511
CDK14	CDKN1C	ENSFCAP00000017585	ENSFCAP00000043917	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1C.	0.511
CDK14	CUL3	ENSFCAP00000017585	ENSFCAP00000043479	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	Cullin 3; Belongs to the cullin family.	0.421
CDK15	CDKN1A	ENSFCAP00000000490	ENSFCAP00000020450	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.525
CDK15	CDKN1B	ENSFCAP00000000490	ENSFCAP00000044526	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.511
CDK15	CDKN1C	ENSFCAP00000000490	ENSFCAP00000043917	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1C.	0.511
CDK15	CUL3	ENSFCAP00000000490	ENSFCAP00000043479	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Cullin 3; Belongs to the cullin family.	0.421
CDK2	CDK1	ENSFCAP00000031371	ENSFCAP00000013888	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.821
CDK2	CDK6	ENSFCAP00000031371	ENSFCAP00000049545	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.866
CDK2	CDKN1A	ENSFCAP00000031371	ENSFCAP00000020450	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.991
CDK2	CDKN1B	ENSFCAP00000031371	ENSFCAP00000044526	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.940