STRINGSTRING
SPRY1 SPRY1 CAV1 CAV1 ZEB1 ZEB1 FGF10 FGF10 FST FST ACVRL1 ACVRL1 HES5 HES5 SOX9 SOX9 SMO SMO DLL1 DLL1 HES1 HES1 JAG1 JAG1 NKX6-3 NKX6-3 FRZB FRZB TBX3 TBX3 YAP1 YAP1 KRAS KRAS NXNL2 NXNL2 HOXA7 HOXA7 NOTCH1 NOTCH1 OSR1 OSR1 SRSF6 SRSF6 SPRY2 SPRY2 NODAL NODAL FOXJ2 FOXJ2 SPRED1 SPRED1 EZH2 EZH2 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRY1Sprouty RTK signaling antagonist 1. (362 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
FSTFollistatin. (423 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
SOX9SRY-box transcription factor 9. (511 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
NKX6-3NK6 homeobox 3. (268 aa)
FRZBFrizzled related protein. (324 aa)
TBX3T-box transcription factor 3. (745 aa)
YAP1Yes associated protein 1. (498 aa)
KRASUncharacterized protein. (380 aa)
NXNL2Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (623 aa)
HOXA7Homeobox A7. (234 aa)
NOTCH1Notch receptor 1. (2543 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
NODALNodal growth differentiation factor. (348 aa)
FOXJ2Forkhead box J2. (572 aa)
SPRED1Sprouty related EVH1 domain containing 1. (443 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.