STRINGSTRING
NFYA NFYA ING2 ING2 PARK7 PARK7 ZNF274 ZNF274 TADA2A TADA2A MCRS1 MCRS1 PHF20 PHF20 PRMT6 PRMT6 OTUB1 OTUB1 MTHFR MTHFR PRKD1 PRKD1 SIRT1 SIRT1 CDK9 CDK9 THAP7 THAP7 GLYR1 GLYR1 PARG PARG MBIP MBIP OGT OGT AKAP8L AKAP8L PIH1D1 PIH1D1 ZNF304 ZNF304 SMAD4 SMAD4 BCOR BCOR PPP4R2 PPP4R2 IGF2 IGF2 MAPK3 MAPK3 LIF LIF SAP30BP SAP30BP ENSFCAP00000036726 ENSFCAP00000036726 PYGO2 PYGO2 ENSFCAP00000038924 ENSFCAP00000038924 PHF1 PHF1 FLCN FLCN CTR9 CTR9 RPS6KA4 RPS6KA4 PHF19 PHF19 PINK1 PINK1 EHMT1 EHMT1 ZZZ3 ZZZ3 RNF20 RNF20 NSD1 NSD1 RPS6KA5 RPS6KA5 SNW1 SNW1 MYB MYB LRRK2 LRRK2 KAT2A KAT2A KANSL3 KANSL3 M3VZ18_FELCA M3VZ18_FELCA YEATS2 YEATS2 RUVBL2 RUVBL2 NOC2L NOC2L KMT2E KMT2E CTCF CTCF NIPBL NIPBL SUPT6H SUPT6H SMARCB1 SMARCB1 WDR5 WDR5 ZMPSTE24 ZMPSTE24 GFI1 GFI1 BCL6 BCL6 KDM4B KDM4B PAXIP1 PAXIP1 ZNF451 ZNF451 IWS1 IWS1 NCAPG2 NCAPG2 BRD7 BRD7 PRKD2 PRKD2 KDM3A KDM3A WDR61 WDR61 UBR5 UBR5 SIN3A SIN3A TRIP12 TRIP12 LMNA LMNA SGF29 SGF29 DR1 DR1 SPHK2 SPHK2 ENSFCAP00000043416 ENSFCAP00000043416 FOXP3 FOXP3 SART3 SART3 DNMT1 DNMT1 SMARCA5 SMARCA5 GATA3 GATA3 PRDM12 PRDM12 KANSL1 KANSL1 TP53 TP53 KAT7 KAT7 ATG5 ATG5 PWWP2A PWWP2A KANSL2 KANSL2 JDP2 JDP2 AUTS2 AUTS2 DNMT3B DNMT3B RPS19 RPS19 MYOCD MYOCD MECP2 MECP2 CHTOP CHTOP NFYC NFYC UCN UCN PAF1 PAF1 OTUB2 OTUB2 MLLT6 MLLT6 EID1 EID1 CTCFL CTCFL PWWP2B PWWP2B FBRSL1 FBRSL1 JARID2 JARID2 EZHIP EZHIP ENSFCAP00000054111 ENSFCAP00000054111 MUC1 MUC1 ARID5A ARID5A CB2H6orf89 CB2H6orf89 ZNF335 ZNF335 CTBP1 CTBP1 SETD5 SETD5 EHMT2 EHMT2 KAT8 KAT8 PAXBP1 PAXBP1 RTF1 RTF1 TET1 TET1 PIWIL2 PIWIL2 BRCA1 BRCA1 NSD3 NSD3 KDM1A KDM1A MACROH2A1 MACROH2A1 PPP4C PPP4C TADA3 TADA3 SDR16C5 SDR16C5 MTF2 MTF2 KPNA7 KPNA7 SETD7 SETD7 CHEK1 CHEK1 KDM4A KDM4A RRP8 RRP8 RIF1 RIF1 ZBTB7B ZBTB7B TADA2B TADA2B ATRX ATRX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFYANuclear transcription factor Y subunit alpha. (347 aa)
ING2Inhibitor of growth protein. (280 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
ZNF274Zinc finger protein 274. (622 aa)
TADA2ATranscriptional adapter. (577 aa)
MCRS1Microspherule protein 1. (541 aa)
PHF20PHD finger protein 20. (1013 aa)
PRMT6Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
OTUB1Ubiquitin thioesterase. (281 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
SIRT1Sirtuin 1. (745 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (492 aa)
THAP7THAP domain containing 7. (313 aa)
GLYR1Glyoxylate reductase 1 homolog. (553 aa)
PARGPoly(ADP-ribose) glycohydrolase. (976 aa)
MBIPMAP3K12 binding inhibitory protein 1. (378 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (650 aa)
PIH1D1PIH1 domain containing 1. (290 aa)
ZNF304Zinc finger protein 304. (612 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCORBCL6 corepressor. (1802 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (415 aa)
IGF2Insulin like growth factor 2. (280 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
SAP30BPSAP30 binding protein. (308 aa)
ENSFCAP00000036726Uncharacterized protein. (182 aa)
PYGO2Pygopus family PHD finger 2. (406 aa)
ENSFCAP00000038924Homeobox domain-containing protein. (316 aa)
PHF1PHD finger protein 1. (567 aa)
FLCNUncharacterized protein. (579 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
PHF19PHD finger protein 19. (548 aa)
PINK1PTEN induced kinase 1. (581 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1312 aa)
ZZZ3Zinc finger ZZ-type containing 3. (988 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
NSD1Nuclear receptor binding SET domain protein 1. (2701 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
SNW1SNW domain containing 1. (570 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
KANSL3KAT8 regulatory NSL complex subunit 3. (903 aa)
M3VZ18_FELCAUncharacterized protein. (138 aa)
YEATS2YEATS domain containing 2. (1411 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (749 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
CTCFCCCTC-binding factor. (727 aa)
NIPBLNipped-B protein. (2805 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (429 aa)
WDR5WD repeat domain 5. (334 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
BCL6BCL6 transcription repressor. (745 aa)
KDM4BLysine demethylase 4B. (1124 aa)
PAXIP1PAX interacting protein 1. (1016 aa)
ZNF451Zinc finger protein 451. (1063 aa)
IWS1Interacts with SUPT6H, CTD assembly factor 1. (873 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1139 aa)
BRD7Bromodomain containing 7. (652 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
KDM3ALysine demethylase 3A. (1324 aa)
WDR61WD repeat domain 61. (305 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
TRIP12Thyroid hormone receptor interactor 12. (2067 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
SGF29SAGA complex associated factor 29. (293 aa)
DR1Down-regulator of transcription 1. (176 aa)
SPHK2DAGKc domain-containing protein. (660 aa)
ENSFCAP00000043416Uncharacterized protein. (392 aa)
FOXP3Forkhead box P3. (501 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (982 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1710 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
GATA3GATA binding protein 3. (444 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (363 aa)
KANSL1KAT8 regulatory NSL complex subunit 1. (1102 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PWWP2APWWP domain containing 2A. (566 aa)
KANSL2KAT8 regulatory NSL complex subunit 2. (545 aa)
JDP2Jun dimerization protein 2. (179 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1258 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa)
RPS19DMRT like family C2. (673 aa)
MYOCDMyocardin. (962 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
CHTOPUncharacterized protein. (249 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
UCNUrocortin. (126 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa)
OTUB2Ubiquitin thioesterase. (314 aa)
MLLT6MLLT6, PHD finger containing. (1198 aa)
EID1Uncharacterized protein. (191 aa)
CTCFLCCCTC-binding factor like. (653 aa)
PWWP2BPWWP domain containing 2B. (639 aa)
FBRSL1Fibrosin like 1. (1086 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1251 aa)
EZHIPUncharacterized protein. (489 aa)
ENSFCAP00000054111Uncharacterized protein. (423 aa)
MUC1Uncharacterized protein. (931 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
CB2H6orf89Chromosome B2 C6orf89 homolog. (422 aa)
ZNF335Zinc finger protein 335. (1446 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (467 aa)
SETD5SET domain containing 5. (1496 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1407 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (462 aa)
PAXBP1PAX3 and PAX7 binding protein 1. (966 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
TET1Tet methylcytosine dioxygenase 1. (2142 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa)
NSD3Nuclear receptor binding SET domain protein 3. (1438 aa)
KDM1ALysine demethylase 1A. (944 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
TADA3Transcriptional adaptor 3. (432 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
KPNA7Karyopherin subunit alpha 7. (326 aa)
SETD7SET domain containing 7, histone lysine methyltransferase. (367 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
KDM4ALysine demethylase 4A. (1067 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (509 aa)
RIF1Replication timing regulatory factor 1. (2479 aa)
ZBTB7BUncharacterized protein. (540 aa)
TADA2BTranscriptional adapter. (420 aa)
ATRXATRX chromatin remodeler. (2486 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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