32 items (Felis catus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (509 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	ZZZ3	Zinc finger ZZ-type containing 3. (988 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
	YEATS2	YEATS domain containing 2. (1411 aa)
	NIPBL	Nipped-B protein. (2805 aa)
	WDR5	WD repeat domain 5. (334 aa)
	BCL6	BCL6 transcription repressor. (745 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1139 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
	SGF29	SAGA complex associated factor 29. (293 aa)
	DR1	Down-regulator of transcription 1. (176 aa)
	TADA3	Transcriptional adaptor 3. (432 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
	ZBTB7B	Uncharacterized protein. (540 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	TADA2A	Transcriptional adapter. (577 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
	SIRT1	Sirtuin 1. (745 aa)
	MBIP	MAP3K12 binding inhibitory protein 1. (378 aa)
	AKAP8L	A-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (650 aa)
	SAP30BP	SAP30 binding protein. (308 aa)
	SPHK2	DAGKc domain-containing protein. (660 aa)
	FOXP3	Forkhead box P3. (501 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	JDP2	Jun dimerization protein 2. (179 aa)
	UCN	Urocortin. (126 aa)
	CB2H6orf89	Chromosome B2 C6orf89 homolog. (422 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (467 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	FOXP3	ENSFCAP00000006325	ENSFCAP00000043740	BCL6 transcription repressor.	Forkhead box P3.	0.847
BCL6	SIRT1	ENSFCAP00000006325	ENSFCAP00000027641	BCL6 transcription repressor.	Sirtuin 1.	0.491
BCL6	TP53	ENSFCAP00000006325	ENSFCAP00000045749	BCL6 transcription repressor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.585
CTBP1	SIRT1	ENSFCAP00000059862	ENSFCAP00000027641	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Sirtuin 1.	0.415
DR1	KAT2A	ENSFCAP00000011556	ENSFCAP00000001984	Down-regulator of transcription 1.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.732
DR1	MBIP	ENSFCAP00000011556	ENSFCAP00000030233	Down-regulator of transcription 1.	MAP3K12 binding inhibitory protein 1.	0.874
DR1	SGF29	ENSFCAP00000011556	ENSFCAP00000011410	Down-regulator of transcription 1.	SAGA complex associated factor 29.	0.879
DR1	TADA2A	ENSFCAP00000011556	ENSFCAP00000022393	Down-regulator of transcription 1.	Transcriptional adapter.	0.898
DR1	TADA3	ENSFCAP00000011556	ENSFCAP00000013169	Down-regulator of transcription 1.	Transcriptional adaptor 3.	0.875
DR1	WDR5	ENSFCAP00000011556	ENSFCAP00000005304	Down-regulator of transcription 1.	WD repeat domain 5.	0.777
DR1	YEATS2	ENSFCAP00000011556	ENSFCAP00000002871	Down-regulator of transcription 1.	YEATS domain containing 2.	0.884
DR1	ZZZ3	ENSFCAP00000011556	ENSFCAP00000001313	Down-regulator of transcription 1.	Zinc finger ZZ-type containing 3.	0.783
FOXP3	BCL6	ENSFCAP00000043740	ENSFCAP00000006325	Forkhead box P3.	BCL6 transcription repressor.	0.847
ING2	TP53	ENSFCAP00000019449	ENSFCAP00000045749	Inhibitor of growth protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.480
ING2	WDR5	ENSFCAP00000019449	ENSFCAP00000005304	Inhibitor of growth protein.	WD repeat domain 5.	0.485
KAT2A	DR1	ENSFCAP00000001984	ENSFCAP00000011556	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Down-regulator of transcription 1.	0.732
KAT2A	MBIP	ENSFCAP00000001984	ENSFCAP00000030233	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	MAP3K12 binding inhibitory protein 1.	0.683
KAT2A	PRMT6	ENSFCAP00000001984	ENSFCAP00000023376	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.485
KAT2A	SGF29	ENSFCAP00000001984	ENSFCAP00000011410	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	SAGA complex associated factor 29.	0.955
KAT2A	SIRT1	ENSFCAP00000001984	ENSFCAP00000027641	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Sirtuin 1.	0.507