Autophagy and beclin 1 regulator 1.

SH3 domain containing GRB2 like, endophilin B1.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Cortactin.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

GIT ArfGAP 1.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Growth factor receptor bound protein 2.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Moesin.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Non-specific serine/threonine protein kinase.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Tyrosine-protein kinase.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...]

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Cortactin.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Growth factor receptor bound protein 2.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Sorting nexin 9.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.

Tyrosine-protein kinase.

Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]

ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.

Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]

Cadherin 17.

Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]

Chromatin licensing and DNA replication factor 1.

Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]

Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]