STRINGSTRING
LMNB1 LMNB1 CTBP1 CTBP1 FAM172A FAM172A DOT1L DOT1L HMGB1 HMGB1 LOC101088142 LOC101088142 CENPV CENPV LMNB2 LMNB2 SIRT6 SIRT6 MECP2 MECP2 MBD3L1 MBD3L1 GALK1 GALK1 HELLS HELLS SMARCA5 SMARCA5 DNMT1 DNMT1 ZDBF2 ZDBF2 EZH1 EZH1 HMGA2 HMGA2 ENSFCAP00000040228 ENSFCAP00000040228 TNP1 TNP1 ASIP ASIP BAHD1 BAHD1 SPTY2D1 SPTY2D1 AXIN1 AXIN1 SIRT1 SIRT1 NDN NDN RB1 RB1 POLE3 POLE3 SMCHD1 SMCHD1 MBD2 MBD2 H3F3A H3F3A RIF1 RIF1 RRP8 RRP8 BAZ2A BAZ2A LMNA LMNA BEND3 BEND3 EZH2 EZH2 NRM NRM UBR2 UBR2 HAT1 HAT1 ZNFX1 ZNFX1 MBD3 MBD3 DNMT3L DNMT3L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (467 aa)
FAM172AFamily with sequence similarity 172 member A. (470 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1817 aa)
HMGB1Uncharacterized protein. (233 aa)
LOC101088142GFA domain-containing protein. (262 aa)
CENPVGFA domain-containing protein. (297 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (718 aa)
SIRT6Sirtuin 6. (412 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
MBD3L1Methyl-CpG binding domain protein 3 like 1. (194 aa)
GALK1Galactokinase 1. (619 aa)
HELLSHelicase, lymphoid specific. (837 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1710 aa)
ZDBF2Zinc finger DBF-type containing 2. (2337 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (829 aa)
HMGA2Uncharacterized protein. (109 aa)
ENSFCAP00000040228Uncharacterized protein. (378 aa)
TNP1Transition protein 1. (55 aa)
ASIPAgouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (182 aa)
BAHD1Bromo adjacent homology domain containing 1. (844 aa)
SPTY2D1SPT2 chromatin protein domain containing 1. (699 aa)
AXIN1Axin 1. (867 aa)
SIRT1Sirtuin 1. (745 aa)
NDNNecdin, MAGE family member. (324 aa)
RB1RB transcriptional corepressor 1. (930 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2002 aa)
MBD2Methyl-CpG binding domain protein 2. (410 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
RIF1Replication timing regulatory factor 1. (2479 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (509 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1909 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
BEND3BEN domain containing 3. (828 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
NRMNurim. (262 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (455 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
MBD3Methyl-CpG binding domain protein 3. (301 aa)
DNMT3LUncharacterized protein. (157 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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