STRINGSTRING
PSMD1 PSMD1 SMAD5 SMAD5 UBE2J2 UBE2J2 TSG101 TSG101 FBXW7 FBXW7 PINK1 PINK1 DDX58 DDX58 RNF20 RNF20 CCT2 CCT2 HSPA9 HSPA9 STING1 STING1 JAK1 JAK1 UQCRC1 UQCRC1 MID1 MID1 SPOP SPOP PIAS2 PIAS2 TCP1 TCP1 PML PML UBE2T UBE2T TRAF2 TRAF2 HERC2 HERC2 HIF1A HIF1A TNFRSF1B TNFRSF1B DAXX DAXX HSPA1L HSPA1L BAG6 BAG6 TRIB1 TRIB1 CASP10 CASP10 MYOD1 MYOD1 TRIM28 TRIM28 ARRDC1 ARRDC1 SKA2 SKA2 HSPBP1 HSPBP1 MUL1 MUL1 UBOX5 UBOX5 WBP1L WBP1L CBS CBS HPX HPX RNF40 RNF40 FAM178B FAM178B RNF31 RNF31 RFFL RFFL UBE2B UBE2B BOK BOK DBT DBT UBE2G1 UBE2G1 ENSFCAP00000056502 ENSFCAP00000056502 ENSFCAP00000056245 ENSFCAP00000056245 USP25 USP25 BID BID LAPTM4A-2 LAPTM4A-2 CASP8 CASP8 GGN GGN PIAS1 PIAS1 AUP1 AUP1 FZD8 FZD8 PPARGC1A PPARGC1A RTN3 RTN3 NKD2 NKD2 ANKRA2 ANKRA2 PSMA3 PSMA3 MAP1LC3B MAP1LC3B UBE2D1 UBE2D1 FZD5 FZD5 THRA THRA NEDD8 NEDD8 PDLIM2 PDLIM2 NFKBIA NFKBIA PAX6 PAX6 NLK NLK ZNF746 ZNF746 UBXN7 UBXN7 STX8 STX8 GABARAPL2 GABARAPL2 CACYBP CACYBP LTBR LTBR EGR2 EGR2 UBXN1 UBXN1 CUL7 CUL7 CUL9 CUL9 UBA52 UBA52 FBXO7 FBXO7 ASB4 ASB4 ANAPC2 ANAPC2 SNX9 SNX9 HSPA5 HSPA5 SHPRH SHPRH SMAD6 SMAD6 CUL5 CUL5 BLZF1 BLZF1 NAE1 NAE1 NPLOC4 NPLOC4 BECN1 BECN1 LRPPRC LRPPRC SMC6 SMC6 AMBRA1 AMBRA1 IKBKE IKBKE XRCC5 XRCC5 CUL4A CUL4A CLU CLU RIPK1 RIPK1 HM13 HM13 SQSTM1 SQSTM1 ERBB3 ERBB3 PA2G4 PA2G4 KDM4A KDM4A ERLIN2 ERLIN2 JKAMP JKAMP ARIH1 ARIH1 PIAS4 PIAS4 BAG1 BAG1 GON7 GON7 UBE2A UBE2A SLF2 SLF2 RALA RALA YWHAZ YWHAZ FANCL FANCL SYT11 SYT11 RPS27A RPS27A RALB RALB UBE2W UBE2W FATE1 FATE1 SKI SKI CDKN1A CDKN1A JUN JUN GABARAP GABARAP PRR5L PRR5L PRKAR1B PRKAR1B RTN4 RTN4 TXNIP TXNIP DERL1 DERL1 AXIN2 AXIN2 CUL1 CUL1 LAPTM5 LAPTM5 MAP1LC3A MAP1LC3A OTUB1 OTUB1 SLF1 SLF1 UBE2L6 UBE2L6 USP13 USP13 MC1R MC1R FAF2 FAF2 VCL VCL RAD18 RAD18 RB1 RB1 CUL2 CUL2 UBE2J1 UBE2J1 MDM2 MDM2 BAG5 BAG5 CAMLG CAMLG FHIT FHIT ENSFCAP00000026617 ENSFCAP00000026617 CUL4B CUL4B MFN2 MFN2 SPART SPART LAPTM4B LAPTM4B AXIN1 AXIN1 USP19 USP19 TRAF5 TRAF5 DIO2 DIO2 NDUFS2 NDUFS2 FZD4 FZD4 RTN2 RTN2 FBXW9 FBXW9 LOC109502223 LOC109502223 TANK TANK PRKAR2B PRKAR2B ENSFCAP00000033453 ENSFCAP00000033453 SCN5A SCN5A DET1 DET1 UBE2K UBE2K SMAD3 SMAD3 USP7 USP7 LOC101095070 LOC101095070 SCAMP3 SCAMP3 TRAF3 TRAF3 GPR37 GPR37 ISG15 ISG15 ARRDC5 ARRDC5 TRIB3 TRIB3 SH3KBP1 SH3KBP1 PACRG PACRG SNCAIP SNCAIP PATZ1 PATZ1 APC APC TRIB2 TRIB2 RNF34 RNF34 FOXO1 FOXO1 SLC22A18 SLC22A18 RTN1 RTN1 PRKACB PRKACB RNF8 RNF8 SPOPL SPOPL MAP1LC3C MAP1LC3C EGFR EGFR ENSFCAP00000041779 ENSFCAP00000041779 ENSFCAP00000041941 ENSFCAP00000041941 GLMN GLMN BAG4 BAG4 SMAD7 SMAD7 PRKN PRKN BAG2 BAG2 CUL3 CUL3 GSK3B GSK3B USP2 USP2 NGFR NGFR UBE2L3 UBE2L3 ENSFCAP00000044926 ENSFCAP00000044926 HDAC6 HDAC6 PRKAR2A PRKAR2A CRK CRK TP53 TP53 WRAP53 WRAP53 MFHAS1 MFHAS1 CACUL1 CACUL1 GPI GPI NEK6 NEK6 CHEK2 CHEK2 PACRGL PACRGL TRAF6 TRAF6 CCDC50 CCDC50 UBASH3A UBASH3A RELA RELA YWHAE YWHAE KCNH2 KCNH2 GABARAPL1 GABARAPL1 WFS1 WFS1 TRAF1 TRAF1 PRKAR1A PRKAR1A DLG3 DLG3 DAXX-2 DAXX-2 BCL10 BCL10
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
UBE2J2UBIQUITIN_CONJUGAT_2 domain-containing protein. (259 aa)
TSG101Tumor susceptibility 101. (400 aa)
FBXW7F-box and WD repeat domain containing 7. (749 aa)
PINK1PTEN induced kinase 1. (581 aa)
DDX58DExD/H-box helicase 58. (929 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
STING1Stimulator of interferon genes. (377 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (481 aa)
MID1Midline 1. (667 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
PIAS2Protein inhibitor of activated STAT 2. (621 aa)
TCP1T-complex 1. (556 aa)
PMLPromyelocytic leukemia. (876 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (189 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4831 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
DAXXDeath domain associated protein. (748 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
BAG6BCL2 associated athanogene 6. (1184 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (482 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
TRIM28Tripartite motif containing 28. (821 aa)
ARRDC1Arrestin domain containing 1. (455 aa)
SKA2Tripartite motif containing 37. (987 aa)
HSPBP1HSPA (Hsp70) binding protein 1. (374 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
UBOX5U-box domain containing 5. (545 aa)
WBP1LWW domain binding protein 1 like. (400 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (633 aa)
HPXAmyloid beta precursor protein binding family B member 1. (1091 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1097 aa)
FAM178BUncharacterized protein. (169 aa)
RNF31Uncharacterized protein. (1081 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (528 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (274 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (489 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (334 aa)
ENSFCAP00000056502Uncharacterized protein. (421 aa)
ENSFCAP0000005624514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (178 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1150 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
LAPTM4A-2Uncharacterized protein. (80 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
GGNGametogenetin. (681 aa)
PIAS1Protein inhibitor of activated STAT 1. (664 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (492 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
RTN3Reticulon. (1034 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (488 aa)
ANKRA2Ankyrin repeat family A member 2. (311 aa)
PSMA3Proteasome subunit alpha type. (258 aa)
MAP1LC3BUncharacterized protein. (309 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
THRAThyroid hormone receptor alpha. (733 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
PDLIM2PDZ and LIM domain 2. (418 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PAX6Paired box 6. (437 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
ZNF746Zinc finger protein 746. (645 aa)
UBXN7UBX domain-containing protein. (519 aa)
STX8Syntaxin 8. (283 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
CACYBPCalcyclin binding protein. (230 aa)
LTBRLymphotoxin beta receptor. (433 aa)
EGR2Early growth response 2. (541 aa)
UBXN1UBX domain protein 1. (296 aa)
CUL7Cullin 7; Belongs to the cullin family. (1695 aa)
CUL9Cullin 9; Belongs to the cullin family. (2523 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
FBXO7F-box protein 7. (444 aa)
ASB4Ankyrin repeat and SOCS box containing 4. (426 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (1031 aa)
SNX9Sorting nexin 9. (678 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1687 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
CUL5Cullin-5; Belongs to the cullin family. (780 aa)
BLZF1Basic leucine zipper nuclear factor 1. (401 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (589 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (608 aa)
BECN1Beclin 1. (448 aa)
LRPPRCLeucine rich pentatricopeptide repeat containing. (1394 aa)
SMC6Structural maintenance of chromosomes 6. (1097 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
XRCC5X-ray repair cross complementing 5. (747 aa)
CUL4ACullin 4A; Belongs to the cullin family. (761 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
HM13Histocompatibility minor 13. (421 aa)
SQSTM1Sequestosome 1. (443 aa)
ERBB3ERBB3. (1339 aa)
PA2G4Proliferation-associated 2G4. (394 aa)
KDM4ALysine demethylase 4A. (1067 aa)
ERLIN2ER lipid raft associated 2. (337 aa)
JKAMPJNK1/MAPK8 associated membrane protein. (311 aa)
ARIH1RBR-type E3 ubiquitin transferase. (555 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
BAG1BCL2 associated athanogene 1. (315 aa)
GON7GON7 subunit of KEOPS complex. (99 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
RALARAS like proto-oncogene A. (206 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
FANCLFA complementation group L. (413 aa)
SYT11Synaptotagmin 11. (431 aa)
RPS27ARibosomal protein S27a. (156 aa)
RALBRAS like proto-oncogene B. (206 aa)
UBE2WUBIQUITIN_CONJUGAT_2 domain-containing protein. (180 aa)
FATE1Fetal and adult testis expressed 1. (183 aa)
SKISKI proto-oncogene. (730 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
PRR5LProline rich 5 like. (384 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
RTN4Reticulon. (1190 aa)
TXNIPThioredoxin interacting protein. (391 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
AXIN2Axin 2. (841 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
LAPTM5Lysosomal protein transmembrane 5. (263 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
OTUB1Ubiquitin thioesterase. (281 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis (By similarity). (317 aa)
FAF2Fas associated factor family member 2. (445 aa)
VCLVinculin. (1066 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (501 aa)
RB1RB transcriptional corepressor 1. (930 aa)
CUL2Cullin 2; Belongs to the cullin family. (744 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (299 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
CUL4BCullin 4B; Belongs to the cullin family. (911 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
SPARTSpartin. (672 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (337 aa)
AXIN1Axin 1. (867 aa)
USP19Ubiquitin specific peptidase 19. (1380 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
DIO2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (132 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (489 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
RTN2Reticulon. (470 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
TANKTRAF family member associated NFKB activator. (445 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (618 aa)
ENSFCAP0000003345314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
DET1DET1 partner of COP1 E3 ubiquitin ligase. (560 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
LOC101095070Uncharacterized protein. (141 aa)
SCAMP3Secretory carrier-associated membrane protein. (347 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
GPR37G protein-coupled receptor 37. (613 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
ARRDC5Arrestin domain containing 5. (342 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (720 aa)
PACRGParkin coregulated. (257 aa)
SNCAIPSynuclein alpha interacting protein. (1014 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
RNF34Ring finger protein 34. (382 aa)
FOXO1Forkhead box O1. (662 aa)
SLC22A18Solute carrier family 22 member 18. (421 aa)
RTN1Reticulon. (1032 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
MAP1LC3CUncharacterized protein. (141 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ENSFCAP00000041779Uncharacterized protein. (112 aa)
ENSFCAP00000041941Uncharacterized protein; Belongs to the heat shock protein 70 family. (620 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
NGFRNerve growth factor receptor. (421 aa)
UBE2L3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (247 aa)
ENSFCAP00000044926Uncharacterized protein. (107 aa)
HDAC6Histone deacetylase 6. (1178 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
WRAP53WD repeat containing antisense to TP53. (537 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1157 aa)
CACUL1CDK2 associated cullin domain 1; Belongs to the cullin family. (369 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (659 aa)
NEK6NIMA related kinase 6. (534 aa)
CHEK2Checkpoint kinase 2. (569 aa)
PACRGLParkin coregulated like. (294 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CCDC50Coiled-coil domain containing 50. (482 aa)
UBASH3AUbiquitin associated and SH3 domain containing A. (684 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1167 aa)
GABARAPL1GABA type A receptor associated protein like 1. (151 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
TRAF1TNF receptor-associated factor. (433 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
DAXX-2Daxx domain-containing protein. (769 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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