Your Input: | |
| | SELENOS | Selenoprotein S. (188 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (124 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (861 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (234 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (819 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) |
| | NUGGC | Nuclear GTPase, germinal center associated. (794 aa) |
| | NFKBIB | NFKB inhibitor beta. (354 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (135 aa) |
| | F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (407 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | HMGB2 | High mobility group box 2. (210 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | BPI | Bactericidal permeability increasing protein. (654 aa) |
| | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (422 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | SRR | Serine racemase. (339 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (785 aa) |
| | SHPK | FGGY_N domain-containing protein. (478 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | FCAR | Ig domain-containing protein. (176 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) |
| | CD274 | CD274 molecule. (297 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (302 aa) |
| | CD80 | B-lymphocyte activation antigen B7-1 (CD80). (292 aa) |
| | BPIFC | BPI fold containing family C. (507 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (397 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (618 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | LOXL1 | Lysyl oxidase like 1. (590 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | TBXA2R | Thromboxane A2 receptor. (392 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (497 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (635 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa) |
| | CLEC17A | C-type lectin domain containing 17A. (367 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2. (409 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa) |
| | CD6 | CD6 molecule. (678 aa) |
| | MALT1 | MALT1 paracaspase. (848 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa) |
| | CXCL6 | C-X-C motif chemokine. (148 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (319 aa) |
| | AKIRIN2 | Akirin 2. (203 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1282 aa) |
| | KCNJ8 | Potassium voltage-gated channel subfamily J member 8. (424 aa) |
| | LDOC1 | LDOC1 regulator of NFKB signaling. (146 aa) |
| | PTGIR | Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | NOCT | Nocturnin. (431 aa) |
| | M3X2M0_FELCA | Uncharacterized protein. (175 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (754 aa) |
| | CD96 | CD96 molecule. (571 aa) |
| | LYN | Tyrosine-protein kinase. (526 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (442 aa) |
| | PLAA | Phospholipase A2 activating protein. (796 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (562 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | IL36RN | Interleukin-1. (196 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | WDR83 | WD repeat domain 83. (315 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (436 aa) |
| | PTGFR | Prostaglandin FP receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (282 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (280 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | ENSFCAP00000030117 | WAP domain-containing protein. (143 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | MEF2C | MADS-box domain-containing protein. (483 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa) |
| | S100A14 | S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa) |
| | LOC100302540 | C-C motif chemokine. (93 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | PTGER4 | Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | AXL | AXL receptor tyrosine kinase. (861 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa) |
| | CXCL11 | C-X-C motif chemokine. (100 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1513 aa) |
| | ENSFCAP00000040772 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (224 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | XBP1 | X-box binding protein 1. (383 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | ENSFCAP00000042577 | DUF4939 domain-containing protein. (113 aa) |
| | PTGER1 | Prostaglandin E receptor 1. (402 aa) |
| | FOXP1 | Forkhead box P1. (693 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | LOC101094096 | C-X-C motif chemokine. (104 aa) |
| | ERBIN | Erbb2 interacting protein. (1461 aa) |
| | ZFP36 | ZFP36 ring finger protein. (513 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (372 aa) |
| | PLSCR4 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (356 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (482 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | LITAF | Uncharacterized protein. (521 aa) |
| | ENSFCAP00000049367 | annotation not available (113 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | IRF8 | Interferon regulatory factor 8. (427 aa) |
| | GCH1 | GTP_cyclohydroI domain-containing protein. (450 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | MRC1 | Mannose receptor C-type 1. (1484 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (498 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (625 aa) |
| | CCR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | CXCL13 | C-X-C motif chemokine. (120 aa) |
| | IL36G | Interleukin-1. (219 aa) |
| | OTUD5 | OTU deubiquitinase 5. (583 aa) |
| | ARID5A | AT-rich interaction domain 5A. (608 aa) |
| | ELANE | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa) |
| | LOC101094344 | C-X-C motif chemokine. (113 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1352 aa) |
| | NFKBIL1 | NFKB inhibitor like 1. (455 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (804 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa) |
| | PALM3 | Paralemmin 3. (810 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1162 aa) |
| | PRDX3 | Peroxiredoxin 3. (270 aa) |
| | CD86 | B-lymphocyte activation antigen B7-2 (CD86). (332 aa) |
| | LBP | Lipopolysaccharide binding protein. (497 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (638 aa) |
| | LOC101093854 | C-X-C motif chemokine. (96 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (551 aa) |
| | PDE4B | Phosphodiesterase. (737 aa) |
| | KLRK1 | Killer cell lectin like receptor K1. (215 aa) |
| | LOC109498011 | Uncharacterized protein. (483 aa) |
