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IL17RA IL17RA SOCS5 SOCS5 C5 C5 APP APP TICAM2 TICAM2 TREM2 TREM2 CSF1R CSF1R AGER AGER IL1B IL1B EIF2AK2 EIF2AK2 NR1H4 NR1H4 SIGIRR SIGIRR AIRE AIRE NOD2 NOD2 IL17F IL17F FFAR2 FFAR2 IFNG IFNG IL33 IL33 EPHA2 EPHA2 ADIPOQ ADIPOQ ARG2 ARG2 SYK SYK DEFB124 DEFB124 SNAI2 SNAI2 RIPK2 RIPK2 IL1RL1 IL1RL1 TLR8 TLR8 TRIM32 TRIM32 C1QTNF3 C1QTNF3 LOC101082108 LOC101082108 IL6 IL6 APOD APOD TLR4 TLR4 SLC37A4 SLC37A4 EGR1 EGR1 HAVCR2 HAVCR2 TLR3 TLR3 CARD9 CARD9 IL7 IL7 IL17A IL17A S100B S100B MYD88 MYD88 TLR9 TLR9 TLR7 TLR7 ACKR1 ACKR1 FOXP1 FOXP1 MCOLN2 MCOLN2 ERBIN ERBIN TIRAP TIRAP ZFPM1 ZFPM1 PYCARD PYCARD TNF TNF ALOX15B ALOX15B TRPV4 TRPV4 CD84 CD84 ELANE ELANE HMGB1 HMGB1 CLEC7A CLEC7A MUL1 MUL1 AIF1 AIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17RAInterleukin 17 receptor A. (862 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
C5Complement C5. (1680 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (541 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
SIGIRRSingle Ig and TIR domain containing. (410 aa)
AIREAutoimmune regulator. (549 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
IL17FInterleukin 17F. (157 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
IL33Interleukin 33. (268 aa)
EPHA2EPH receptor A2. (936 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
ARG2Arginase. (354 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
SNAI2Uncharacterized protein. (268 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
TRIM32Uncharacterized protein. (669 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
APODApolipoprotein D. (189 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
IL7Interleukin 7. (158 aa)
IL17AInterleukin 17A. (155 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
TLR7TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa)
ACKR1Atypical chemokine receptor 1 (Duffy blood group). (339 aa)
FOXP1Forkhead box P1. (693 aa)
MCOLN2Mucolipin 2. (563 aa)
ERBINErbb2 interacting protein. (1461 aa)
TIRAPTIR domain containing adaptor protein. (220 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
CD84CD84 molecule. (369 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa)
HMGB1Uncharacterized protein. (233 aa)
CLEC7AC-type lectin domain containing 7A. (250 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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