Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARID5A | ZC3H12A | ENSFCAP00000056492 | ENSFCAP00000008119 | AT-rich interaction domain 5A. | Zinc finger CCCH-type containing 12A. | 0.408 |
| AXL | CLEC7A | ENSFCAP00000035876 | ENSFCAP00000058516 | AXL receptor tyrosine kinase. | C-type lectin domain containing 7A. | 0.807 |
| AXL | FADD | ENSFCAP00000035876 | ENSFCAP00000045141 | AXL receptor tyrosine kinase. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.504 |
| AXL | GAS6 | ENSFCAP00000035876 | ENSFCAP00000006408 | AXL receptor tyrosine kinase. | Growth arrest specific 6. | 0.999 |
| AXL | TLR4 | ENSFCAP00000035876 | ENSFCAP00000023731 | AXL receptor tyrosine kinase. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.420 |
| AXL | TNF | ENSFCAP00000035876 | ENSFCAP00000051032 | AXL receptor tyrosine kinase. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.567 |
| BCL3 | CEBPG | ENSFCAP00000021762 | ENSFCAP00000050010 | BCL3 transcription coactivator. | BZIP domain-containing protein. | 0.408 |
| CCR7 | FOXP3 | ENSFCAP00000038973 | ENSFCAP00000043740 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Forkhead box P3. | 0.843 |
| CCR7 | GATA3 | ENSFCAP00000038973 | ENSFCAP00000044199 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | GATA binding protein 3. | 0.492 |
| CCR7 | HAVCR2 | ENSFCAP00000038973 | ENSFCAP00000028327 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Hepatitis A virus cellular receptor 2. | 0.571 |
| CCR7 | IL10 | ENSFCAP00000038973 | ENSFCAP00000012535 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.657 |
| CCR7 | IL18 | ENSFCAP00000038973 | ENSFCAP00000027095 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.444 |
| CCR7 | IL1B | ENSFCAP00000038973 | ENSFCAP00000005482 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.591 |
| CCR7 | IL2 | ENSFCAP00000038973 | ENSFCAP00000012696 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.648 |
| CCR7 | IRF8 | ENSFCAP00000038973 | ENSFCAP00000050371 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interferon regulatory factor 8. | 0.446 |
| CCR7 | KLRK1 | ENSFCAP00000038973 | ENSFCAP00000061501 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Killer cell lectin like receptor K1. | 0.446 |
| CCR7 | LTA | ENSFCAP00000038973 | ENSFCAP00000004152 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | 0.579 |
| CCR7 | TLR4 | ENSFCAP00000038973 | ENSFCAP00000023731 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.439 |
| CCR7 | TNF | ENSFCAP00000038973 | ENSFCAP00000051032 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.716 |
| CD14 | RIPK3 | ENSFCAP00000001187 | ENSFCAP00000005200 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Receptor interacting serine/threonine kinase 3. | 0.415 |
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