STRINGSTRING
IL12B IL12B DDIT3 DDIT3 TGFB1 TGFB1 IL21 IL21 NR1H4 NR1H4 NOD2 NOD2 IFNG IFNG IL12A IL12A IL23A IL23A SLC7A5 SLC7A5 VSIR VSIR IL2 IL2 ARG2 ARG2 IL15 IL15 ZBTB7B ZBTB7B RFTN1 RFTN1 TUSC2 TUSC2 TLR4 TLR4 IL36RN IL36RN IL18 IL18 PRNP PRNP CARD9 CARD9 SLAMF6 SLAMF6 OSM OSM MYD88 MYD88 PRKCQ PRKCQ PHB PHB NCKAP1L NCKAP1L FOXP3 FOXP3 ARID5A ARID5A ENSFCAP00000057195 ENSFCAP00000057195 TNFSF4 TNFSF4 IL27RA IL27RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
ARG2Arginase. (354 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
ZBTB7BUncharacterized protein. (540 aa)
RFTN1Raftlin, lipid raft linker 1. (555 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL36RNInterleukin-1. (196 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
SLAMF6Ig-like domain-containing protein. (390 aa)
OSMOncostatin M. (238 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
PHBProhibitin. (272 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
FOXP3Forkhead box P3. (501 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
ENSFCAP00000057195Uncharacterized protein. (34 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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