STRINGSTRING
RASGRP1 RASGRP1 IL12RB1 IL12RB1 IL27RA IL27RA KLRK1 KLRK1 PDE4B PDE4B CD2 CD2 PDE4D PDE4D CLEC7A CLEC7A TNFSF4 TNFSF4 CD160 CD160 ARID5A ARID5A TNF TNF PYCARD PYCARD IRF8 IRF8 CEBPG CEBPG ZFPM1 ZFPM1 LOC101090771 LOC101090771 LOC111560445 LOC111560445 FADD FADD FAM49B FAM49B ENSFCAP00000040280 ENSFCAP00000040280 ENSFCAP00000039745 ENSFCAP00000039745 TLR7 TLR7 TLR9 TLR9 IL18R1 IL18R1 ISG15 ISG15 SLAMF6 SLAMF6 TLR3 TLR3 HAVCR2 HAVCR2 IL18 IL18 IL12B IL12B ENSFCAP00000025816 ENSFCAP00000025816 TLR4 TLR4 CD226 CD226 TRIM27 TRIM27 BCL3 BCL3 HSPD1 HSPD1 TLR8 TLR8 LRRC1 LRRC1 RIPK2 RIPK2 TXK TXK IL2 IL2 ZP3 ZP3 IL27 IL27 SLC7A5 SLC7A5 IL23A IL23A IL12A IL12A TYK2 TYK2 IL1B IL1B SASH3 SASH3 ABL1 ABL1 LTA LTA SLAMF1 SLAMF1 TICAM2 TICAM2 IL12RB2 IL12RB2 IL23R IL23R CD14 CD14 CRTAM CRTAM SCRIB SCRIB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASGRP1RAS guanyl releasing protein 1. (877 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
KLRK1Killer cell lectin like receptor K1. (215 aa)
PDE4BPhosphodiesterase. (737 aa)
CD2CD2 molecule. (376 aa)
PDE4DPhosphodiesterase. (809 aa)
CLEC7AC-type lectin domain containing 7A. (250 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
CD160CD160 molecule. (221 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IRF8Interferon regulatory factor 8. (427 aa)
CEBPGBZIP domain-containing protein. (465 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
LOC111560445Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
FAM49BFamily with sequence similarity 49 member B. (378 aa)
ENSFCAP00000040280Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
ENSFCAP00000039745Uncharacterized protein. (55 aa)
TLR7TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
SLAMF6Ig-like domain-containing protein. (390 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
ENSFCAP00000025816Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
CD226CD226 molecule. (332 aa)
TRIM27Tripartite motif containing 27. (513 aa)
BCL3BCL3 transcription coactivator. (454 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TXKTyrosine-protein kinase. (551 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (435 aa)
IL27Interleukin 27. (236 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (861 aa)
IL23RInterleukin 23 receptor. (631 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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