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RAB7B | RAB7B, member RAS oncogene family. (297 aa) | ||||
CLEC7A | C-type lectin domain containing 7A. (250 aa) | ||||
TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa) | ||||
HMGB1 | Uncharacterized protein. (233 aa) | ||||
ARID5A | AT-rich interaction domain 5A. (608 aa) | ||||
INAVA | Innate immunity activator. (656 aa) | ||||
TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) | ||||
PYCARD | PYD and CARD domain containing. (195 aa) | ||||
UCN | Urocortin. (126 aa) | ||||
TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) | ||||
SPHK2 | DAGKc domain-containing protein. (660 aa) | ||||
IL17RC | Interleukin 17 receptor C. (651 aa) | ||||
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) | ||||
ENSFCAP00000040280 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa) | ||||
ENSFCAP00000039745 | Uncharacterized protein. (55 aa) | ||||
TLR7 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa) | ||||
TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa) | ||||
NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) | ||||
NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) | ||||
ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1181 aa) | ||||
IL17A | Interleukin 17A. (155 aa) | ||||
LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) | ||||
POU2F2 | POU domain protein. (688 aa) | ||||
CARD9 | Caspase recruitment domain family member 9. (732 aa) | ||||
IL17D | Interleukin 17D. (202 aa) | ||||
PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) | ||||
TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa) | ||||
POU2AF1 | POU class 2 homeobox associating factor 1. (256 aa) | ||||
EREG | Epiregulin. (169 aa) | ||||
C1QTNF4 | C1q domain-containing protein. (98 aa) | ||||
ENSFCAP00000025816 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa) | ||||
TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) | ||||
IFIH1 | Interferon induced with helicase C domain 1. (1026 aa) | ||||
HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa) | ||||
DHX9 | DExH-box helicase 9. (1373 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) | ||||
ZBTB20 | Zinc finger and BTB domain containing 20. (741 aa) | ||||
TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa) | ||||
DDX58 | DExD/H-box helicase 58. (929 aa) | ||||
APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa) | ||||
TICAM2 | Toll like receptor adaptor molecule 2. (234 aa) | ||||
F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa) | ||||
LOC102899310 | Ig-like domain-containing protein. (320 aa) | ||||
AGER | Advanced glycosylation end-product specific receptor. (492 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) | ||||
CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa) | ||||
NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) | ||||
IL17F | Interleukin 17F. (157 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) | ||||
SETD4 | SET domain containing 4. (453 aa) | ||||
TMEM106A | Transmembrane protein 106A. (262 aa) | ||||
SYK | Spleen associated tyrosine kinase. (636 aa) | ||||
MMP8 | Matrix metallopeptidase 8. (476 aa) | ||||
AKIRIN2 | Akirin 2. (203 aa) | ||||
IL1RAP | Interleukin 1 receptor accessory protein. (639 aa) | ||||
IL17RA | Interleukin 17 receptor A. (862 aa) | ||||
MAPK13 | Mitogen-activated protein kinase. (402 aa) | ||||
AIF1 | Allograft inflammatory factor 1. (157 aa) |