STRINGSTRING
RAB7B RAB7B CLEC7A CLEC7A TNFSF4 TNFSF4 HMGB1 HMGB1 ARID5A ARID5A INAVA INAVA TRPV4 TRPV4 TNF TNF PYCARD PYCARD UCN UCN TRAF6 TRAF6 SPHK2 SPHK2 IL17RC IL17RC PLCG2 PLCG2 ENSFCAP00000040280 ENSFCAP00000040280 ENSFCAP00000039745 ENSFCAP00000039745 TLR7 TLR7 TLR9 TLR9 NOD1 NOD1 NOS2 NOS2 MYD88 MYD88 ARHGEF2 ARHGEF2 IL17A IL17A LEP LEP POU2F2 POU2F2 CARD9 CARD9 IL17D IL17D PTPN11 PTPN11 TLR3 TLR3 POU2AF1 POU2AF1 EREG EREG C1QTNF4 C1QTNF4 ENSFCAP00000025816 ENSFCAP00000025816 TLR4 TLR4 IL6 IL6 IFIH1 IFIH1 HSPD1 HSPD1 DHX9 DHX9 RIPK2 RIPK2 ZBTB20 ZBTB20 TLR8 TLR8 DDX58 DDX58 APP APP TICAM2 TICAM2 F2R F2R LOC102899310 LOC102899310 AGER AGER IL1B IL1B CYBA CYBA NOD2 NOD2 IL17F IL17F IFNG IFNG SETD4 SETD4 TMEM106A TMEM106A SYK SYK MMP8 MMP8 AKIRIN2 AKIRIN2 IL1RAP IL1RAP IL17RA IL17RA MAPK13 MAPK13 AIF1 AIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB7BRAB7B, member RAS oncogene family. (297 aa)
CLEC7AC-type lectin domain containing 7A. (250 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
HMGB1Uncharacterized protein. (233 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
INAVAInnate immunity activator. (656 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
PYCARDPYD and CARD domain containing. (195 aa)
UCNUrocortin. (126 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SPHK2DAGKc domain-containing protein. (660 aa)
IL17RCInterleukin 17 receptor C. (651 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
ENSFCAP00000040280Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
ENSFCAP00000039745Uncharacterized protein. (55 aa)
TLR7TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1181 aa)
IL17AInterleukin 17A. (155 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
POU2F2POU domain protein. (688 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
IL17DInterleukin 17D. (202 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
POU2AF1POU class 2 homeobox associating factor 1. (256 aa)
EREGEpiregulin. (169 aa)
C1QTNF4C1q domain-containing protein. (98 aa)
ENSFCAP00000025816Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
IFIH1Interferon induced with helicase C domain 1. (1026 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
DHX9DExH-box helicase 9. (1373 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
DDX58DExD/H-box helicase 58. (929 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LOC102899310Ig-like domain-containing protein. (320 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
IL17FInterleukin 17F. (157 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
SETD4SET domain containing 4. (453 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
MMP8Matrix metallopeptidase 8. (476 aa)
AKIRIN2Akirin 2. (203 aa)
IL1RAPInterleukin 1 receptor accessory protein. (639 aa)
IL17RAInterleukin 17 receptor A. (862 aa)
MAPK13Mitogen-activated protein kinase. (402 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (24%) [HD]