STRINGSTRING
PHIP PHIP PDK2 PDK2 CSRP3 CSRP3 PIK3R1 PIK3R1 GPLD1 GPLD1 GHSR GHSR GRB10 GRB10 SOGA1 SOGA1 LPIN2 LPIN2 IGF1R IGF1R TBC1D4 TBC1D4 OTOP1 OTOP1 SMARCC1 SMARCC1 ADIPOQ ADIPOQ SLC27A1 SLC27A1 SLC2A1 SLC2A1 RARRES2 RARRES2 RAB15 RAB15 PPARG PPARG RAB13 RAB13 ZNF106 ZNF106 C2CD5 C2CD5 STXBP4 STXBP4 PCK2 PCK2 IRS2 IRS2 PIK3R3 PIK3R3 PKLR PKLR ENSFCAP00000044386 ENSFCAP00000044386 GSK3B GSK3B PIK3R2 PIK3R2 PTPN2 PTPN2 PKM PKM INSIG1 INSIG1 INHBB INHBB FOXO1 FOXO1 APC APC PTPRA PTPRA TRIB3 TRIB3 LPIN1 LPIN1 RHOQ RHOQ WDTC1 WDTC1 ENPP1 ENPP1 INPP5K INPP5K AKT2 AKT2 GRB14 GRB14 SLC27A4 SLC27A4 INSIG2 INSIG2 USF1 USF1 EIF4EBP2 EIF4EBP2 NDEL1 NDEL1 ANKRD26 ANKRD26 RAB31 RAB31 RAB10 RAB10 TRARG1 TRARG1 CAPN10 CAPN10 APPL1 APPL1 BCAR3 BCAR3 LEP LEP FOXO4 FOXO4 NCOA5 NCOA5 INSR INSR LPIN3 LPIN3 SH2B2 SH2B2 PRKCI PRKCI RB1 RB1 ZFP36L1 ZFP36L1 GRB2 GRB2 CPEB2 CPEB2 GOT1 GOT1 GSK3A GSK3A RPS6KB1 RPS6KB1 ZDHHC7 ZDHHC7 LOC101100432 LOC101100432 RAB8B RAB8B SLC2A8 SLC2A8 PARP6 PARP6 CAV2 CAV2 SYAP1 SYAP1 IRS1 IRS1 RAB12 RAB12 PDK4 PDK4 INSRR INSRR LOC101081229 LOC101081229 SP1 SP1 PCK1 PCK1 IRS4 IRS4 SHC1 SHC1 SLC39A14 SLC39A14 DENND4C DENND4C PDPK1 PDPK1 GHRHR GHRHR EPRS1 EPRS1 POU4F2 POU4F2 SLC2A4 SLC2A4 DNAI1 DNAI1 GH1 GH1 AKT3 AKT3 PTPN1 PTPN1 KAT2B KAT2B AKT1 AKT1 PARP1 PARP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHIPPleckstrin homology domain interacting protein. (1821 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
CSRP3Cysteine and glycine rich protein 3. (271 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (873 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1657 aa)
LPIN2Lipin 2. (936 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TBC1D4TBC1 domain family member 4. (1297 aa)
OTOP1Otopetrin 1. (607 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1104 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
SLC27A1Solute carrier family 27 member 1. (796 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
RARRES2Retinoic acid receptor responder 2. (451 aa)
RAB15Uncharacterized protein. (425 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RAB13Uncharacterized protein. (203 aa)
ZNF106Zinc finger protein 106. (1902 aa)
C2CD5C2 calcium dependent domain containing 5. (1126 aa)
STXBP4Uncharacterized protein. (562 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PIK3R3Uncharacterized protein. (461 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (634 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
PKMPyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). (531 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa)
INHBBInhibin subunit beta B. (407 aa)
FOXO1Forkhead box O1. (662 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (826 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
LPIN1Lipin 1. (976 aa)
RHOQRas homolog family member Q. (214 aa)
WDTC1WD and tetratricopeptide repeats 1. (700 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (525 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
GRB14Growth factor receptor bound protein 14. (717 aa)
SLC27A4Solute carrier family 27 member 4. (691 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
USF1Upstream transcription factor 1. (444 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (142 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (480 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
RAB31RAB31, member RAS oncogene family. (210 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (725 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (935 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
FOXO4Forkhead box O4. (515 aa)
NCOA5Nuclear receptor coactivator 5. (544 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
LPIN3Lipin 3. (1036 aa)
SH2B2SH2B adaptor protein 2. (679 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
RB1RB transcriptional corepressor 1. (930 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1045 aa)
GOT1Aspartate aminotransferase. (413 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
LOC101100432Uncharacterized protein. (514 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
SLC2A8Solute carrier family 2 member 8. (315 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa)
SYAP1Synapse associated protein 1. (358 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
RAB12RAB12, member RAS oncogene family. (339 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
INSRRTyrosine-protein kinase receptor. (1300 aa)
LOC101081229Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa)
SP1Sp1 transcription factor. (786 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
SHC1SHC adaptor protein 1. (566 aa)
SLC39A14Solute carrier family 39 member 14. (491 aa)
DENND4CDENN domain containing 4C. (1957 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1576 aa)
POU4F2POU domain protein. (408 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
DNAI1Dynein axonemal intermediate chain 1. (719 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (246 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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