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PNPLA8 PNPLA8 SCD5 SCD5 MGLL MGLL SCD SCD PLAA PLAA PLA2G4A PLA2G4A ELOVL4 ELOVL4 GPX1 GPX1 EPHX1 EPHX1 PLA2G2F PLA2G2F ELOVL6 ELOVL6 LOC105259649 LOC105259649 CYP2E2 CYP2E2 PTGIS PTGIS PRXL2B PRXL2B PTGR1 PTGR1 PTGES PTGES LOC105260134 LOC105260134 CYP1B1 CYP1B1 LOC101089561 LOC101089561 LOC109492298 LOC109492298 ATP6V1B1 ATP6V1B1 ELOVL1 ELOVL1 HPGDS HPGDS LOC101089396 LOC101089396 PLA2G10 PLA2G10 CYP2D6 CYP2D6 ALOX15B ALOX15B AKR1C3 AKR1C3 MRRF MRRF ENSFCAP00000056898 ENSFCAP00000056898 GSTP1 GSTP1 TBXAS1 TBXAS1 LOC101087695 LOC101087695 ELOVL2 ELOVL2 AKR1E2 AKR1E2 ALOX5 ALOX5 CYP2S1 CYP2S1 AKR1B1 AKR1B1 PTGES2 PTGES2 DAGLB DAGLB LOC101089816 LOC101089816 DECR2 DECR2 ZADH2 ZADH2 TNFRSF1A TNFRSF1A PTGES3 PTGES3 HPGD HPGD ALOX12 ALOX12 ELOVL5 ELOVL5 PTGDS PTGDS CYP1A2 CYP1A2 DAGLA DAGLA FADS1 FADS1 EDN2 EDN2 EDN1 EDN1 ALOX12B ALOX12B ALOXE3 ALOXE3 CYP2U1 CYP2U1 LOC101089311 LOC101089311 ACOX1 ACOX1 PTGR2 PTGR2 FADS3 FADS3 LOC101085921 LOC101085921 LOC109492144 LOC109492144 CYP2F1 CYP2F1 LOC101089804 LOC101089804 PTGS2 PTGS2 FADS2 FADS2 GPX4 GPX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PNPLA8Patatin like phospholipase domain containing 8. (781 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
MGLLMonoglyceride lipase. (368 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (405 aa)
PLAAPhospholipase A2 activating protein. (796 aa)
PLA2G4APhospholipase A2. (749 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
EPHX1Epoxide hydrolase 1. (565 aa)
PLA2G2FPhospholipase A(2). (211 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
LOC105259649Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
CYP2E2Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
PRXL2BPeroxiredoxin like 2B. (434 aa)
PTGR1Prostaglandin reductase 1. (330 aa)
PTGESProstaglandin E synthase. (153 aa)
LOC105260134Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
LOC101089561Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
LOC109492298FA_desaturase domain-containing protein. (333 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (287 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
LOC101089396Uncharacterized protein; Belongs to the cytochrome P450 family. (431 aa)
PLA2G10Phospholipase A(2). (162 aa)
CYP2D6Uncharacterized protein; Belongs to the cytochrome P450 family. (541 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
AKR1C3Aldo_ket_red domain-containing protein. (419 aa)
MRRFProstaglandin-endoperoxide synthase 1. (633 aa)
ENSFCAP00000056898Uncharacterized protein. (72 aa)
GSTP1Uncharacterized protein; Belongs to the GST superfamily. (438 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (558 aa)
LOC101087695Uncharacterized protein. (476 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (305 aa)
AKR1E2Aldo-keto reductase family 1 member E2. (368 aa)
ALOX5Arachidonate 5-lipoxygenase. (745 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (493 aa)
AKR1B1Aldo-keto reductase family 1 member B. (316 aa)
PTGES2Prostaglandin E synthase 2. (373 aa)
DAGLBDiacylglycerol lipase beta. (692 aa)
LOC101089816Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
DECR22,4-dienoyl-CoA reductase 2. (241 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
PTGES3Prostaglandin E synthase 3. (164 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (364 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa)
DAGLADiacylglycerol lipase alpha. (1044 aa)
FADS1Fatty acid desaturase 1. (360 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (544 aa)
LOC101089311Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
PTGR2Uncharacterized protein. (351 aa)
FADS3Fatty acid desaturase 3. (544 aa)
LOC101085921Cytochrome b5 heme-binding domain-containing protein. (484 aa)
LOC109492144Cytochrome b5 heme-binding domain-containing protein. (447 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (498 aa)
LOC101089804Uncharacterized protein; Belongs to the cytochrome P450 family. (486 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FADS2Fatty acid desaturase 2. (444 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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