STRINGSTRING
BCR BCR SYK SYK HRG HRG P2RX7 P2RX7 INPP5D INPP5D DCSTAMP DCSTAMP TNFSF11 TNFSF11 THBS4 THBS4 DEF8 DEF8 CSF1R CSF1R CARTPT CARTPT FSHR FSHR FCGR3A FCGR3A TNFRSF11A TNFRSF11A GPR137B GPR137B NF1 NF1 PPARGC1B PPARGC1B LTBP3 LTBP3 TMEM119 TMEM119 TP53 TP53 HAND2 HAND2 LEPR LEPR ADAM8 ADAM8 ROCK1 ROCK1 PPP3CA PPP3CA SFRP1 SFRP1 DDR2 DDR2 TFRC TFRC LEP LEP PLEKHM1 PLEKHM1 UBASH3B UBASH3B GPNMB GPNMB M3XAD3_FELCA M3XAD3_FELCA SUCO SUCO IAPP IAPP SIGLEC15 SIGLEC15 TMEM64 TMEM64 IL20RA IL20RA PDK4 PDK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
HRGHistidine rich glycoprotein. (536 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1181 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
THBS4Thrombospondin 4. (964 aa)
DEF8Differentially expressed in FDCP 8 homolog. (563 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
CARTPTCART prepropeptide. (116 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
FCGR3ACD16. (250 aa)
TNFRSF11ATNF receptor superfamily member 11a. (638 aa)
GPR137BG protein-coupled receptor 137B. (620 aa)
NF1Neurofibromin 1. (2856 aa)
PPARGC1BPPARG coactivator 1 beta. (1006 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1302 aa)
TMEM119Transmembrane protein 119. (279 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
HAND2Heart and neural crest derivatives expressed 2. (275 aa)
LEPRLeptin receptor. (1166 aa)
ADAM8ADAM metallopeptidase domain 8. (872 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1066 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
GPNMBGlycoprotein nmb. (568 aa)
M3XAD3_FELCAUncharacterized protein. (225 aa)
SUCOSUN domain containing ossification factor. (1254 aa)
IAPPIslet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. (89 aa)
SIGLEC15Sialic acid binding Ig like lectin 15. (331 aa)
TMEM64Transmembrane protein 64. (391 aa)
IL20RAInterleukin 20 receptor subunit alpha. (712 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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