(20 nodes) Positive regulation of toll-like receptor signaling pathway network (Felis catus)

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	TLR9	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (1157 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (498 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (801 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
	IFI35	Interferon induced protein 35. (287 aa)
	CXHXorf21	Chromosome X CXorf21 homolog. (333 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (234 aa)
	WDFY1	WD repeat and FYVE domain containing 1. (564 aa)
	RTN4	Reticulon. (1190 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	PJA2	Praja ring finger ubiquitin ligase 2. (699 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (747 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (363 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	FLOT1	ENSFCAP00000029296	ENSFCAP00000007129	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.796
CD14	TLR3	ENSFCAP00000001187	ENSFCAP00000028836	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.443
CD14	TLR9	ENSFCAP00000001187	ENSFCAP00000038661	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.431
FLOT1	CAV1	ENSFCAP00000007129	ENSFCAP00000029296	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.796
HMGB1	TLR3	ENSFCAP00000058007	ENSFCAP00000028836	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.607
HMGB1	TLR9	ENSFCAP00000058007	ENSFCAP00000038661	Uncharacterized protein.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.915
IFI35	RSAD2	ENSFCAP00000021542	ENSFCAP00000030881	Interferon induced protein 35.	Radical S-adenosyl methionine domain containing 2.	0.657
MFHAS1	PJA2	ENSFCAP00000046267	ENSFCAP00000012334	Malignant fibrous histiocytoma amplified sequence 1.	Praja ring finger ubiquitin ligase 2.	0.513
PJA2	MFHAS1	ENSFCAP00000012334	ENSFCAP00000046267	Praja ring finger ubiquitin ligase 2.	Malignant fibrous histiocytoma amplified sequence 1.	0.513
RSAD2	IFI35	ENSFCAP00000030881	ENSFCAP00000021542	Radical S-adenosyl methionine domain containing 2.	Interferon induced protein 35.	0.657
RSAD2	TLR3	ENSFCAP00000030881	ENSFCAP00000028836	Radical S-adenosyl methionine domain containing 2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.534
TICAM2	TLR3	ENSFCAP00000001898	ENSFCAP00000028836	Toll like receptor adaptor molecule 2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.752
TICAM2	TLR9	ENSFCAP00000001898	ENSFCAP00000038661	Toll like receptor adaptor molecule 2.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.934
TLR3	CD14	ENSFCAP00000028836	ENSFCAP00000001187	Toll like receptor 3; Belongs to the Toll-like receptor family.	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	0.443
TLR3	HMGB1	ENSFCAP00000028836	ENSFCAP00000058007	Toll like receptor 3; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.607
TLR3	RSAD2	ENSFCAP00000028836	ENSFCAP00000030881	Toll like receptor 3; Belongs to the Toll-like receptor family.	Radical S-adenosyl methionine domain containing 2.	0.534
TLR3	TICAM2	ENSFCAP00000028836	ENSFCAP00000001898	Toll like receptor 3; Belongs to the Toll-like receptor family.	Toll like receptor adaptor molecule 2.	0.752
TLR3	TLR9	ENSFCAP00000028836	ENSFCAP00000038661	Toll like receptor 3; Belongs to the Toll-like receptor family.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.832
TLR9	CD14	ENSFCAP00000038661	ENSFCAP00000001187	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	0.431
TLR9	HMGB1	ENSFCAP00000038661	ENSFCAP00000058007	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	Uncharacterized protein.	0.915