STRINGSTRING
SPO11 SPO11 IK IK RUVBL2 RUVBL2 NIPBL NIPBL ZNF827 ZNF827 PINX1 PINX1 LEMD2 LEMD2 RPA1 RPA1 NRM NRM EZH2 EZH2 KNTC1 KNTC1 ACD ACD MAU2 MAU2 RCC2 RCC2 MCM8 MCM8 NABP2 NABP2 PLK1 PLK1 MIS12 MIS12 MSH2 MSH2 RAD21 RAD21 MACROH2A1 MACROH2A1 ESCO2 ESCO2 CDK1 CDK1 ATR ATR ANKRD39 ANKRD39 SLF2 SLF2 BUB3 BUB3 ATRX ATRX TTK TTK BRCA2 BRCA2 STAG3 STAG3 TERF2IP TERF2IP H3F3A H3F3A ESR1 ESR1 POT1 POT1 HASPIN HASPIN IFFO1 IFFO1 SLF1 SLF1 RB1 RB1 MCM9 MCM9 TASOR TASOR XRCC4 XRCC4 SMC5 SMC5 TNKS TNKS PIH1D1 PIH1D1 TERF2 TERF2 WAPL WAPL PARP3 PARP3 ENSFCAP00000043416 ENSFCAP00000043416 MACROH2A2 MACROH2A2 IFFO2 IFFO2 GALK1 GALK1 TINF2 TINF2 TNKS2 TNKS2 CENPA CENPA MRNIP MRNIP KNL1 KNL1 AURKB AURKB JARID2 JARID2 ENSFCAP00000054111 ENSFCAP00000054111 MTBP MTBP CHAMP1 CHAMP1 CHMP7 CHMP7 SPDL1 SPDL1 ENSFCAP00000056502 ENSFCAP00000056502 BUB1B BUB1B FAM178B FAM178B TMPRSS5 TMPRSS5 LRWD1 LRWD1 ENSFCAP00000060774 ENSFCAP00000060774 ZWILCH ZWILCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
IKIK cytokine. (555 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
NIPBLNipped-B protein. (2805 aa)
ZNF827Zinc finger protein 827. (1082 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
LEMD2LEM domain containing 2. (566 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (618 aa)
NRMNurim. (262 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
KNTC1Kinetochore associated 1. (2207 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (453 aa)
MAU2MAU2 sister chromatid cohesion factor. (652 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (833 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
MIS12MIS12 kinetochore complex component. (432 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
RAD21RAD21 cohesin complex component. (631 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (602 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
ANKRD39Ankyrin repeat domain 39. (183 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
ATRXATRX chromatin remodeler. (2486 aa)
TTKTTK protein kinase. (856 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
STAG3Stromal antigen 3. (1230 aa)
TERF2IPTERF2 interacting protein. (406 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
POT1Protection of telomeres 1. (785 aa)
HASPINHistone H3 associated protein kinase. (782 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (570 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
RB1RB transcriptional corepressor 1. (930 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
TASORTranscription activation suppressor. (1665 aa)
XRCC4X-ray repair cross complementing 4. (332 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PIH1D1PIH1 domain containing 1. (290 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
WAPLWAPL cohesin release factor. (1196 aa)
PARP3Poly [ADP-ribose] polymerase. (538 aa)
ENSFCAP00000043416Uncharacterized protein. (392 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (517 aa)
GALK1Galactokinase 1. (619 aa)
TINF2TERF1 interacting nuclear factor 2. (466 aa)
TNKS2Poly [ADP-ribose] polymerase. (1344 aa)
CENPACentromere protein A. (138 aa)
MRNIPMRN complex interacting protein. (348 aa)
KNL1Kinetochore scaffold 1. (2183 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (408 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1251 aa)
ENSFCAP00000054111Uncharacterized protein. (423 aa)
MTBPMDM2 binding protein. (911 aa)
CHAMP1Chromosome alignment maintaining phosphoprotein 1. (823 aa)
CHMP7Charged multivesicular body protein 7. (456 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa)
ENSFCAP00000056502Uncharacterized protein. (421 aa)
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B. (1062 aa)
FAM178BUncharacterized protein. (169 aa)
TMPRSS5Zw10 kinetochore protein. (848 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (823 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
ZWILCHZwilch kinetochore protein. (630 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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