STRINGSTRING
NEDD4 NEDD4 ENPP1 ENPP1 ENSFCAP00000060347 ENSFCAP00000060347 INPP5K INPP5K AKT2 AKT2 GNB5 GNB5 DRD3 DRD3 CALM3 CALM3 CLIC2 CLIC2 NEDD4L NEDD4L DRD4 DRD4 FABP5 FABP5 REM1 REM1 TNF TNF CALM1 CALM1 ACTN2 ACTN2 ARL6IP5 ARL6IP5 KCNH2 KCNH2 SLC30A1 SLC30A1 MRLN MRLN APPL2 APPL2 AKT3 AKT3 PEA15 PEA15 AKT1 AKT1 PLN PLN REM2 REM2 KCNE2 KCNE2 KCNE1 KCNE1 EPO EPO KCNE3 KCNE3 HECW1 HECW1 OAZ3 OAZ3 PRKCB PRKCB SLC43A1 SLC43A1 HECW2 HECW2 CRBN CRBN PID1 PID1 SMIM6 SMIM6 LOC101085272 LOC101085272 SESTD1 SESTD1 CB1H4orf3 CB1H4orf3 FKBP1B FKBP1B GRP GRP TLR9 TLR9 SLC43A2 SLC43A2 KCNE5 KCNE5 SLC9A3R1 SLC9A3R1 KCNE4 KCNE4 LEP LEP GOPC GOPC HAMP HAMP CAV1 CAV1 ENSFCAP00000029012 ENSFCAP00000029012 LOC101097703 LOC101097703 CALML3 CALML3 ANO9 ANO9 PKD2 PKD2 PPIF PPIF CASQ2 CASQ2 KCNRG KCNRG GSK3A GSK3A OSTN OSTN OSR1 OSR1 SRI SRI RRAD RRAD M3WQU5_FELCA M3WQU5_FELCA STXBP3 STXBP3 CALM2 CALM2 GEM GEM KEL KEL CTTNBP2NL CTTNBP2NL OXSR1 OXSR1 GRB10 GRB10 THBS1 THBS1 OAZ2 OAZ2 STK39 STK39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEDD4NEDD4 E3 ubiquitin protein ligase. (1323 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (525 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
GNB5G protein subunit beta 5. (403 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
CLIC2Chloride intracellular channel 2. (284 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1246 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein. (595 aa)
FABP5Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (184 aa)
REM1RRAD and GEM like GTPase 1. (238 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
ACTN2Actinin alpha 2. (910 aa)
ARL6IP5PRA1 family protein. (188 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1167 aa)
SLC30A1Solute carrier family 30 member 1. (503 aa)
MRLNUncharacterized protein. (46 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PEA15DED domain-containing protein. (130 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (182 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (132 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1633 aa)
OAZ3Uncharacterized protein. (234 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC43A1Solute carrier family 43 member 1. (687 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1577 aa)
CRBNCereblon. (518 aa)
PID1Phosphotyrosine interaction domain containing 1. (252 aa)
SMIM6Small integral membrane protein 6. (60 aa)
LOC101085272Uncharacterized protein. (905 aa)
SESTD1SEC14 and spectrin domain containing 1. (758 aa)
CB1H4orf3Uncharacterized protein. (68 aa)
FKBP1BPeptidylprolyl isomerase. (238 aa)
GRPUncharacterized protein. (265 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
SLC43A2Solute carrier family 43 member 2. (572 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (137 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (175 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
GOPCPDZ domain-containing protein. (463 aa)
HAMPHepcidin antimicrobial peptide. (83 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ANO9Anoctamin. (769 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (204 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
KCNRGPotassium channel regulator. (273 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
OSTNOsteocrin. (132 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SRISorcin. (247 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
KELKell metallo-endopeptidase. (787 aa)
CTTNBP2NLCTTNBP2 N-terminal like. (639 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
THBS1Thrombospondin 1. (1170 aa)
OAZ2Uncharacterized protein. (189 aa)
STK39Serine/threonine kinase 39. (543 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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