STRINGSTRING
ENSFCAP00000059591 ENSFCAP00000059591 AKT2 AKT2 ENSFCAP00000060347 ENSFCAP00000060347 STAC STAC WNK4 WNK4 STAC3 STAC3 R3HDM2 R3HDM2 LRRC38 LRRC38 PDPK1 PDPK1 TRPC3 TRPC3 TREM2 TREM2 POU4F2 POU4F2 CD19 CD19 F2R F2R C1QTNF12 C1QTNF12 AKT3 AKT3 VMP1 VMP1 HTT HTT AKT1 AKT1 ABL1 ABL1 WNK3 WNK3 COX17 COX17 RNF207 RNF207 KCNE1 KCNE1 NPSR1 NPSR1 FGF21 FGF21 STIM1 STIM1 HSPA2 HSPA2 ADRB2 ADRB2 GRM6 GRM6 STAC2 STAC2 SLC9A1 SLC9A1 AKAP6 AKAP6 PIK3R1 PIK3R1 NFE2L2 NFE2L2 P2RX7 P2RX7 BRAF BRAF KCNIP2 KCNIP2 ADIPOQ ADIPOQ EDN1 EDN1 AMIGO1 AMIGO1 CRACR2A CRACR2A SLC17A8 SLC17A8 CALM2 CALM2 M3WQU5_FELCA M3WQU5_FELCA F2 F2 RAB44 RAB44 CXCR3 CXCR3 SRI SRI TRPC1 TRPC1 ATP1B3 ATP1B3 TCAF1 TCAF1 CREBL2 CREBL2 STIM2 STIM2 MEF2A MEF2A SLC26A6 SLC26A6 TCAF2 TCAF2 ATPSCKMT ATPSCKMT STIMATE STIMATE PRKCI PRKCI RNASEL RNASEL COA8 COA8 PKD2 PKD2 CAPN9 CAPN9 LRRC52 LRRC52 R3HDM1 R3HDM1 AZIN2 AZIN2 CALML3 CALML3 LOC101097703 LOC101097703 ENSFCAP00000029012 ENSFCAP00000029012 CAV1 CAV1 AZIN1 AZIN1 PTPN11 PTPN11 INSR INSR CASQ1 CASQ1 PIRT PIRT ITGB1 ITGB1 OPN3 OPN3 APPL1 APPL1 LRRC55 LRRC55 CAPN10 CAPN10 ARC ARC RHOQ RHOQ KCNE5 KCNE5 OSBPL8 OSBPL8 NDUFA4 NDUFA4 CXCL11 CXCL11 CHP1 CHP1 FLNA FLNA FGF19 FGF19 TRPC6 TRPC6 CACNB3 CACNB3 EDNRA EDNRA GPC3 GPC3 CFTR CFTR RAMP3 RAMP3 ENSFCAP00000041489 ENSFCAP00000041489 IGF1 IGF1 PTH PTH PLCG2 PLCG2 CHP2 CHP2 ATP2A1 ATP2A1 THY1 THY1 CXCL10 CXCL10 GPER1 GPER1 CAPN3 CAPN3 ENSFCAP00000044386 ENSFCAP00000044386 ANO6 ANO6 P2RX4 P2RX4 KCNQ1 KCNQ1 CXCL9 CXCL9 C2CD5 C2CD5 NR4A3 NR4A3 LOC101081130 LOC101081130 KCNH2 KCNH2 DRD1 DRD1 ERFE ERFE ACTN2 ACTN2 CALM1 CALM1 KCNIP4 KCNIP4 PDZK1 PDZK1 SLC1A2 SLC1A2 ACSL5 ACSL5 CLIP3 CLIP3 WNK1 WNK1 F2RL3 F2RL3 DRD4 DRD4 RYR2 RYR2 CA2 CA2 FXYD1 FXYD1 ENSFCAP00000055268 ENSFCAP00000055268 CALM3 CALM3 WNK2 WNK2 TESC TESC TRDN TRDN RELN RELN CEMIP CEMIP ATP1B2 ATP1B2 BAK1 BAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSFCAP00000059591Uncharacterized protein. (1233 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
STACSH3 and cysteine rich domain. (422 aa)
WNK4WNK lysine deficient protein kinase 4. (1322 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
R3HDM2Uncharacterized protein. (1043 aa)
LRRC38Leucine rich repeat containing 38. (297 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (925 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
POU4F2POU domain protein. (408 aa)
CD19CD19 molecule. (641 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
C1QTNF12C1q and TNF related 12. (297 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VMP1Vacuole membrane protein 1. (406 aa)
HTTHuntingtin. (3140 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
WNK3WNK lysine deficient protein kinase 3. (1794 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
RNF207Ring finger protein 207. (634 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (132 aa)
NPSR1Neuropeptide S receptor 1. (370 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
STIM1Stromal interaction molecule 1. (799 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
GRM6Glutamate metabotropic receptor 6. (878 aa)
STAC2SH3 and cysteine rich domain 2. (411 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (759 aa)
AKAP6A-kinase anchoring protein 6. (2330 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
CRACR2ACalcium release activated channel regulator 2A. (723 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
RAB44RAB44, member RAS oncogene family. (984 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
SRISorcin. (247 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
TCAF1TRPM8 channel associated factor 1. (1024 aa)
CREBL2cAMP responsive element binding protein like 2. (120 aa)
STIM2Stromal interaction molecule 2. (840 aa)
MEF2AMyocyte enhancer factor 2A. (542 aa)
SLC26A6Solute carrier family 26 member 6. (756 aa)
TCAF2Peptidase M60 domain-containing protein. (919 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (227 aa)
STIMATEUncharacterized protein. (294 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
RNASELRibonuclease L. (724 aa)
COA8Cytochrome c oxidase assembly factor 8. (205 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (690 aa)
LRRC52Leucine rich repeat containing 52. (315 aa)
R3HDM1R3H domain containing 1. (1133 aa)
AZIN2Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (549 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
AZIN1Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
LRRC55Leucine rich repeat containing 55. (318 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (725 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
RHOQRas homolog family member Q. (214 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (137 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (1518 aa)
NDUFA4Uncharacterized protein. (82 aa)
CXCL11C-X-C motif chemokine. (100 aa)
CHP1Calcineurin like EF-hand protein 1. (341 aa)
FLNAFilamin A. (2808 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (550 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
RAMP3Receptor activity modifying protein 3. (150 aa)
ENSFCAP00000041489Uncharacterized protein. (82 aa)
IGF1Insulin like growth factor 1. (195 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CXCL10C-X-C motif chemokine. (98 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
ANO6Anoctamin. (932 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (389 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (692 aa)
CXCL9C-X-C motif chemokine. (155 aa)
C2CD5C2 calcium dependent domain containing 5. (1126 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (651 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1167 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
ERFEErythroferrone. (343 aa)
ACTN2Actinin alpha 2. (910 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (250 aa)
PDZK1PDZ domain containing 1. (584 aa)
SLC1A2Amino acid transporter. (579 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (670 aa)
CLIP3CAP-Gly domain containing linker protein 3. (571 aa)
WNK1WNK lysine deficient protein kinase 1. (2924 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (401 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein. (595 aa)
RYR2Ryanodine receptor 2. (4967 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (263 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
ENSFCAP00000055268Anaphylatoxin-like domain-containing protein. (1626 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
WNK2WNK lysine deficient protein kinase 2. (2159 aa)
TESCTescalcin. (379 aa)
TRDNTriadin. (721 aa)
RELNReelin. (3460 aa)
CEMIPCell migration inducing hyaluronidase 1. (1397 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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