STRINGSTRING
CCDC40 CCDC40 SHH SHH SMO SMO DLL1 DLL1 CLUAP1 CLUAP1 AHI1-2 AHI1-2 RYR2 RYR2 ASB2 ASB2 SUFU SUFU ZIC3 ZIC3 HES1 HES1 YAP1 YAP1 TBX3 TBX3 NPHP3 NPHP3 TBX6 TBX6 MED1 MED1 HAND2 HAND2 MEGF8 MEGF8 SOX18 SOX18 EDNRA EDNRA SOX17 SOX17 AHI1 AHI1 SMAD3 SMAD3 MEF2C MEF2C APELA APELA NKX2-6 NKX2-6 PKD2 PKD2 LBX1 LBX1 MESP1 MESP1 TBX2 TBX2 NOTCH2 NOTCH2 MIB1 MIB1 IFT52 IFT52 DNAAF1 DNAAF1 TBX20 TBX20 ECE1 ECE1 EDN1 EDN1 HAND1 HAND1 CCDC103 CCDC103 IHH IHH IFT57 IFT57 SRF SRF NOTCH1 NOTCH1 ARL13B ARL13B LOC101091046 LOC101091046 CITED2 CITED2 FOXH1 FOXH1 GJA5 GJA5 NODAL NODAL ENG ENG TEAD2 TEAD2 HIF1A HIF1A FGF8 FGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDC40Coiled-coil domain containing 40. (1152 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
CLUAP1Clusterin associated protein 1. (477 aa)
AHI1-2Uncharacterized protein. (55 aa)
RYR2Ryanodine receptor 2. (4967 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (670 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
ZIC3Zic family member 3. (553 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
YAP1Yes associated protein 1. (498 aa)
TBX3T-box transcription factor 3. (745 aa)
NPHP3TPR_REGION domain-containing protein. (1348 aa)
TBX6T-box transcription factor 6. (436 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
HAND2Heart and neural crest derivatives expressed 2. (275 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
SOX18SRY-box transcription factor 18. (465 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SOX17SRY-box transcription factor 17. (406 aa)
AHI1Abelson helper integration site 1. (951 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
APELAUncharacterized protein. (54 aa)
NKX2-6NK2 homeobox 6. (299 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
LBX1Ladybird homeobox 1. (281 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (261 aa)
TBX2T-box transcription factor 2. (713 aa)
NOTCH2Notch receptor 2. (2493 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1016 aa)
IFT52Intraflagellar transport 52. (446 aa)
DNAAF1Dynein assembly factor 1, axonemal. (641 aa)
TBX20T-box transcription factor 20. (480 aa)
ECE1Endothelin converting enzyme 1. (754 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
CCDC103Coiled-coil domain containing 103. (249 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
IFT57Intraflagellar transport 57. (429 aa)
SRFSerum response factor. (512 aa)
NOTCH1Notch receptor 1. (2543 aa)
ARL13BADP ribosylation factor like GTPase 13B. (427 aa)
LOC101091046Uncharacterized protein. (1716 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FOXH1Forkhead box H1. (361 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
NODALNodal growth differentiation factor. (348 aa)
ENGEndoglin. (654 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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