STRINGSTRING
EGF EGF SOCS5 SOCS5 AREG AREG EFEMP1 EFEMP1 SHC1 SHC1 PDPK1 PDPK1 VILL VILL VIL1 VIL1 ABL1 ABL1 TGFB1 TGFB1 PLCE1 PLCE1 PIGR PIGR BRAF BRAF FAM83B FAM83B ERBB3 ERBB3 SLC30A10 SLC30A10 GAREM1 GAREM1 EREG EREG PTK2B PTK2B SOS1 SOS1 CPNE3 CPNE3 MVP MVP GRB2 GRB2 MAPK1 MAPK1 PTPN11 PTPN11 MYOC MYOC BTC BTC PTK2 PTK2 IQGAP1 IQGAP1 NRG3 NRG3 FAM83A FAM83A EPGN EPGN TGFA TGFA SRC SRC EGFR EGFR GAREM2 GAREM2 ERBB4 ERBB4 SOX9 SOX9 PTPRR PTPRR KIF16B KIF16B PLCG1 PLCG1 RASSF2 RASSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
AREGAmphiregulin. (323 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (504 aa)
SHC1SHC adaptor protein 1. (566 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
VILLVillin like. (855 aa)
VIL1Villin 1. (827 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
PIGRPolymeric immunoglobulin receptor. (760 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
FAM83BFamily with sequence similarity 83 member B. (1011 aa)
ERBB3ERBB3. (1339 aa)
SLC30A10Solute carrier family 30 member 10. (483 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (876 aa)
EREGEpiregulin. (169 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CPNE3Copine 3. (564 aa)
MVPMajor vault protein. (892 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (498 aa)
BTCBetacellulin. (194 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
NRG3Neuregulin 3. (720 aa)
FAM83AFAM83 domain-containing protein. (435 aa)
EPGNEpithelial mitogen. (153 aa)
TGFATransforming growth factor alpha. (192 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (869 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SOX9SRY-box transcription factor 9. (511 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (655 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1802 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
RASSF2Ras association domain family member 2. (375 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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